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Using the Chiari-like Malformation & Syringomyelia Evaluation (CHASE) Questionnaire* to Assess the Safety & Efficacy of a Novel Pain Management Product in Dogs

Principal Investigator

Natasha Olby


The goals of this study are to evaluate a newly developed questionnaire to assess pain and clinical signs associated with CM/SM in dogs and to evaluate how well a novel veterinary pain management product might treat the condition.

Dogs with signs of CM/SM dogs will visit NC State Veterinary hospital for an initial screening visit to assess their overall health and clinical signs and to perform testing to confirm that they have CM/SM. They will be enrolled in the study for a total of about a month and will need to visit twice more, at about 2 weeks and 4 weeks after enrolling. At the start of the study, your dog will be randomized to receive either the study drug, or a placebo for 2 weeks. After 2 weeks, your pet will be assigned to the alternate group. You will be provided rescue pain medications that you can use in case your dog requires additional pain management at home during the study. You will be asked to complete a survey at three four time points to assess your dog’s clinical signs associated with CM/SM, will need to maintain a diary to capture any abnormal signs or behaviors while your dog is on the study, and will be asked to maintain a record of each time you administer medications to your dog.

Testing Requirements


Enrollment Start


Enrollment Finish



• Generally healthy Cavalier King Charles Spaniels (6 months- 8 years of age)
• Displaying signs of CM/SM
• Able to wear a collar or harness
• Not receiving gabapentin or pregabalin in the 7 days prior to study enrollment
• Able to undergo anesthesia for MRI diagnosis of their condition




Amanda Valentino