Efficacy of Alkaline Therapy for Metabolic Acidosis in Dogs with Chronic Kidney Disease (CKD)

Principle Investigator Drs. Autumn N. Harris and Shelly L. Vaden Description Chronic kidney disease (CKD) is a common condition in dogs and often progresses over time despite standard medical management. A frequent complication of CKD is metabolic acidosis, a condition in which excess acid accumulates in the body. This imbalance has been associated with worsening…

Evaluation of Renal Pathology After Treatment in Dogs with Chronic Kidney Disease

Principle Investigator Dr. Autum Harris Description The objective of this study is to evaluate whether a monoclonal antibody targeting transforming growth factor beta (TGF-β) can slow the progression of chronic kidney disease (CKD) in dogs with early-stage disease. Chronic kidney disease is a progressive condition in which long-term kidney damage can lead to worsening kidney…

C-K9 STRIDE: Resistance Training Intervention for Dogs with Chronic Kidney Disease (CKD)

Principle Investigator Drs. Autumn N. Harris, Leslie-Reed Jones, and Shelly L. Vaden Description Chronic kidney disease (CKD) in dogs is commonly associated with loss of muscle mass (sarcopenia), which can contribute to weakness, decreased mobility, and reduced quality of life. In human medicine, resistance training is a well-established, non-pharmacologic intervention that improves muscle mass, strength,…

Observation of Feeding Practices in Privately Owned Cats with Chronic Kidney Disease (CKD): A Pilot Study

Principle Investigator Dr. Autumn Harris Description Nutritional management is a cornerstone of care for cats with chronic kidney disease (CKD), yet accurately assessing what cats consume in the home environment remains a significant challenge. Cats are often inconsistent eaters, and discrepancies frequently exist between the amount of food offered and the amount actually consumed. This…

CATNIP: Evaluation of Comprehensive Assessment Techniques and Novel Indicators of Progression in Feline CKD Study.

Principle Investigator Autumn N. Harris and Shelly Vaden Description The objective of this study is to evaluate novel technology indicators of CKD progression in cats. This evaluation will include cats with Stage 2 or Stage 3 CKD, as well as healthy non-CKD controls. Your veterinarian will determine if your cat is eligible for study and…

Efficacy of Potassium Citrate as a Treatment for Metabolic Acidosis in Cats with Chronic Kidney Disease

Principle Investigators Autumn N. Harris and Shelly Vaden Description Chronic Kidney Disease (CKD) is defined as the presence of functional abnormalities in one or both kidneys over a prolonged period of time. CKD is the most common typeof kidney disease and management has largely been focused on supportive and symptomatic therapy, with very few new…

Effect of Iron Supplementation on the response to Varenzin-CA1 in Cats with CKD and Anemia

Principle Investigators Autumn N. Harris and Shelly Vaden Description Anemia is common in feline chronic kidney disease (CKD) and several options are available for treatment including the medication Varenzin CA-1 ® . Iron supplementation is an important part of the treatment of anemia in some patients with CKD and is given as standard of care…

Ammonia Excretion, A Novel Biomarker and Therapeutic Target for Feline CKD

Principle Investigator Dr. Harris Description Chronic Kidney Disease (CKD) is defined as the presence of functional abnormalities in one or both kidneys over a prolonged period of time. Serum creatinine is currently used as a marker of kidney function, but it cannot detect early changes in kidney function. Detecting CKD early has significant importance because…

Novel Biomarker and Therapeutic Target for CKD in Dogs

Principle Investigator Dr. Harris Description Chronic Kidney Disease (CKD) is defined as the presence of functional abnormalities in one or both kidneys over a prolonged period of time. Serum creatinine is currently used as a marker of kidney function, but it cannot detect early changes in kidney function. Detecting CKD early has significant importance because…

Enrolling Dogs with Invasive Bladder Cancer

Principle Investigator Dr. Paul Hess Description NC State Medical Oncology is enrolling patients for a clinical trial of an experimental immunotherapy for the treatment of bladder cancer. The primary purpose of this study is to investigate the safety and immune-stimulating properties of a novel therapy being developed at NCSU. Testing Requirements 8-day study (Monday –…