Clinical Trials: Dogs

THE IMPACT OF GI HEALTH ON JOINTS: A CLINICAL STUDY

Principle Investigator Duncan Lascelles Description NC State University College of Veterinary Medicine is seeking dogs with or without mobility problems that are 5 years of age or older and weigh at least 10 kg to take part in a study aiming to evaluate the relationship between intestinal permeability and multiple joint osteoarthritis. Eligibility To be eligible… 

Screening urine samples from high-risk dog breeds for early bladder cancer

Principle Investigator Dr Shelly Vaden Description This study is screening urine samples from clinically healthy dogs at increased risk of bladder cancer, to determine if they test positive for a genetic marker of the disease (a specific mutation in the dog BRAF gene). The goal is to determine whether this BRAF Mutation Detection test can… 

Therapeutic trials for canine bladder cancer

Principle Investigator Dr Shelly Vaden Description This study will investigate whether the administration of a dietary supplement slows the progression of canine bladder cancer (also known as transitional cell carcinoma/urothelial carcinoma, or TCC/UC) in dogs treated with standard of care therapy Testing Requirements Participants will be asked to: – bring their dog for an initial… 

Now Enrolling Dogs with Bladder Cancer

Principle Investigator Dr. Michael Mastromauro Description NC State University College of Veterinary Medicine is enrolling in a clinical trial to investigate if a probiotic can improve cancer care and outcomes in dogs with bladder cancer. This is a placebo-controlled study, not all dogs will receive the probiotic, but all dogs will receivechemotherapy (vinblastine/piroxicam). Testing Requirements Dogs… 

Using the Chiari-like Malformation & Syringomyelia Evaluation (CHASE) Questionnaire* to Assess the Safety & Efficacy of a Novel Pain Management Product in Dogs

Principle Investigator Natasha Olby Description The goals of this study are to evaluate a newly developed questionnaire to assess pain and clinical signs associated with CM/SM in dogs and to evaluate how well a novel veterinary pain management product might treat the condition. Dogs with signs of CM/SM dogs will visit NC State Veterinary hospital for… 

Phase 1 Dose Escalation of Single-Agent Mechlorethamine HCl in Dogs with Lymphoma

Principle Investigator Dr. Joanne Intile Description We are recruiting dogs with lymphoma to determine the optimal dose of a chemotherapy drug called mustargen. Enrolled dogs will receive one free dose of mustargen and undergo follow up blood work for up to two weeks afterwards. Dogs can then receive other chemotherapy drugs, either at NCSU CVM… 

DOGS WITH NON-SEASONAL ATOPIC DERMATITIS TO INVESTIGATE THE EFFECTIVENESS OF TWO DIFFERENT DOSAGES OF A NOVEL IMMUNOTHERAPY DRUG

Principle Investigator Petra Bizikova Description Dogs with Non-Seasonal Atopic Dermatitis to Investigate the Effectiveness of Two Different Dosages of a Novel Immunotherapy Drug Testing Requirements – Patients will be required to come in for 10 visits over 24 weeks – Allergen-Specific IgE Serology (ASIS) testing at Heska – Patients will be required to stay for… 

THE EFFECT OF A NEW COMBINATION OF DIETARY SUPPLEMENTS ON ACTIVITY AND ATTENTION IN AGING DOGS

Description The Canine Neuro-aging Program at NC State College of Veterinary Medicine is recruiting dogs 10 years of age and older to participate in a study on a combination of anti-aging supplements aimed to improve cognitive function, mobility, and quality of life in older dogs. The basis for this study is rooted in our desire to… 

LONGITUDINAL STUDY OF NEURO-AGING IN DOGS

Principle Investigator Natasha Olby Description Canine Cognitive Dysfunction is an age-related neurobehavioral condition that shares similar features to Alzheimer’s disease observed in humans. The progression of this devastating disease ultimately leads to the decline in cognitive function, severely affecting comfort of life for dogs and their owners. The purpose of this study is to track… 

EARLY INTERVENTION FOR DOBERMAN PINSCHERS AT RISK OF DEVELOPING DILATED CARDIOMYOPATHY

Principle Investigator Kathryn Meurs Description We recently identified a genetic mutation in the Titin gene as a common cause of fatal dilated cardiomyopathy in the Doberman pinscher. Dogs that develop the disease frequently die of the disease either from refractory congestive heart failure or sudden cardiac death. Previous studies have demonstrated that medical intervention of… 

DOGS DIAGNOSED WITH PRIMARY SPONTANEOUS PNEUMOTHORAX

Principle Investigator Valery Scharf Description NC State University College of Veterinary Medicine is evaluating the feasibility of thoracoscopy (minimally invasive surgery) for the identification and localization of pulmonary bullae associated with spontaneous pneumothorax. The current approach to this disease is open surgical exploration via a median sternotomy; by demonstrating the ability of thoracoscopy to identify pulmonary… 

CLINICAL TRIAL FOR DOGS WITH PRIMARY ANGLE CLOSURE GLAUCOMA

Principle Investigator Hans Westermeyer Testing Requirements Your dog will receive an exam from the NC State Ophthalmology Service 1 month after study enrollment and once every 3 months thereafter. Each visit will include: sedation, a complete ophthalmic exam, photography and ultrasound of the eye’s drainage apparatus, retinal thickness measurement, and quantitative pupillary light reflex evaluation. A… 

MEDICAL RESOLUTION OF GALLBLADDER MUCOCELE FORMATION IN DOGS

Principle Investigator Jody Gookin Testing Requirements – Exclusive feeding of Royal Canin Gastrointestinal Low Fat dry or canned food with a 10% snack allowance for up to 1 year (paid for by study). Your dog’s feeding plan will be prescribed and monitored by a veterinary nutritionist. – Oral administration of up to 15 capsules of… 

IS YOUR DOG OVERWEIGHT?

Principle Investigator Duncan Lascelles Description NC State University College of Veterinary Medicine is looking for overweight dogs. The goal of this clinical trial is to evaluate the efficacy of an investigative diet as nutritional management for overweight dogs. Owners will receive 6 months of free premium dog food, a free automatic pet food feeder and dog… 

INSPIRE THERAPY FOR CANINE MAMMARY CARCINOMA

Principle Investigator Kyle Mathews Description Dogs with mammary tumors are eligible for a clinical trial investigating a new therapy called INSPIRE, which uses electrical pulses to safely destroy the membranes of cells within a tumor. A week after INSPIRE therapy, your dog will be readmitted to the NC State surgical service to undergo a mastectomy for… 

Investigating the Efficacy of a Dietary Supplement in Delaying the Progression of Canine Urothelial Carcinoma/Bladder Cancer 

Principle Investigator Dr Shelly Vaden Description This study will investigate: 1. whether urine-based screening for a genetic marker (a specific mutation in the BRAF gene) can detect canine urothelial carcinoma/bladder cancer before the onset of clinical signs. 2. whether a dietary supplement delays the onset of clinical signs in dogs that have a detectable urinary… 

Osteoarthritis Oral Microbiome Analysis in Dogs

Principle Investigator Jody Gookin Description A one-time saliva sample from your dog to analyze their oral microbiome (the microbial composition of their mouths). The analysis will allow us to identify patterns associated with the presence or absence of certain diseases. Testing Requirements A one-time visit to NCSU for a physical exam and  saliva sample.  There… 

CARPROFEN USE IN LACTATING DOGS

Principle Investigator Sara Lyle Description This study is looking at determining the safety of carprofen, brand name Rimadyl, in dogs who are nursing and if there are measurable amounts found in the bloodstream of their nursing puppies. This study is the first to look at both the dams and nursing puppies, and will help guide… 

FUNCTIONAL CONNECTIVITY MRI IN DOGS WITH IDIOPATHIC EPILEPSY

Principle Investigator Karen Munana Description We are recruiting dogs with idiopathic epilepsy that have experienced at least 2 seizures and are not on antiseizure medications. Dogs that qualify will receive a brain MRI and spinal tap free of charge. For additional details, see: Epilepsy functional MRI Testing Requirements None Enrollment Start 06/01/2022 Enrollment Finish 12/31/2023…