Research Irradiation Core Facility
The X-RAD 320 is a self-contained X-ray system for delivering a precise radiation dosage to specimens in a biological or small animal research laboratory. The shielded cabinet includes an adjustable specimen shelf, sample-viewing window and beam hardening filter holder.
The TouchRAD control panel is a multi-user, password protected touch screen interface with a transportable database that can track individual system usage. A super-user controls passwords, programmed exposure settings, and database management.
The X-ray tube is used specifically for radiation therapy having a highly homogenous beam. Options available include dose measurement & control, motorized specimen shelf, turntable, fixed beam collimators, adjustable collimator, and specimen holding fixtures.
The NC State Veterinary Hospital has a clinical linear accelerator that is also available for research use. Interested users may seek consultation with one of the CVM Radiation Oncologists (Dr. Mike Nolan, Dr. Tracy Gieger, or Dr. Hiroto Yoshikawa).
Rates, Effective August 2020:
|Service (per hour)||NCSU / Internal Users||External Clients*|
|Consultation & Training||$90.00||$137.00|
|X-RAD 320XL - Unassisted||$60||--|
|X-RAD 320XL - Assisted||$100||$152.00|
|Anesthesia - Technical Support†||$27.00||$42.00|
|Anesthesia - Equipment Rental‡||$8.82||$13.50|
- Internal users may hire:
- The Irradiator Core to perform cell and/or material irradiations; contact Mr. Javid Mohammed.
- CPL for animal irradiations; contact CPL directly. For anesthesia support, use: https://cvm.ncsu.edu/lar-forms/ and click on the Rodent Anesthesia Request Form; this is how you can reserve supplies and/or a technician. After that has been submitted, a Vet Services Tech will follow up with you to confirm the procedure and add it to their calendar.
- Unassisted use is available to trained internal users (see Training tab).
- Training will be free-of-charge during calendar year 2020; thereafter, 1 hour of consultation will be charged for training.
- External users must hire the core to perform irradiations.
- To understand our processes, please read the entire website.
- To tell us about your project and request our services, please complete this form: https://forms.gle/qJ9zXiMCc1gk3zBz6.
- If needed, the Irradiator Core personnel can help you to coordinate with CPL for animal irradiations and/or anesthesia.
Project Approvals and Radiation Safety Oversight
All research projects involving the irradiator must be approved by the NC State Radiation Safety Office. This includes vetting of the proposed research by the Radiation Safety Committee’s subcommittee for research at the College fo Veterinary Medicine. Such review is automatically included in the process of acquiring BUA and/or IACUC approval. If your project does not involve or require BUA/IACUC approval, please contact the Radiation Safety office to discuss an alternate route for project approval.
Development of New Irradiation Protocols
Researchers are able to deliver radiation once a new protocol has been established in the X-RAD device. This requires calibration, and programming of the device; that process can only be performed by a “Super User”, generally a Core Facility Manager. Dr. Nolan is also available to assist with protocol development (e.g., design of new/complicated irradiation procedures; troubleshooting; etc.).
- Complete the NC State University CVM Irradiator Access Form, found at: https://forms.gle/PSrzBfG1q5QTziRk9. Once the form is completed, it will be reviewed by both the Radiation Safety Office, and the PI of record for the irradiator. You will then be assigned to the necessary training course (# ehps-rs210 in NCSU Reporter) — that course is not public, so you cannot search for it — instead, you will receive an email with a link to the course.
- Upon completion of the training course, print the Competency Checklist (available via REPORTER) and arrange for Mr. Javid Mohammed to go through it with you and sign off on you being a “User”.
- Mr. Mohammed will then approve you as a user, which will prompt our system to give you swipe card access to the room where the irradiator is housed. Note that completion of this approval process may take up to five business days.
X-RAD Cell Radiation Core Facility
CVM Main Building, Room F123
North Carolina State University – College of Veterinary Medicine
Raleigh, NC 27607
The Research Irradiation Core Facility is led by a committed scientific director (Dr. Kathryn Meurs), and two experienced core facility managers (Ms. Maria Stone and Mr. Javid Mohammed). An Advisory Committee has been formed to provide advice and oversight regarding Facility management and operations. The committee includes 4 volunteer members, each with a minimum term commitment of 3 years. The NC State Radiation Safety office has permanent representation on this committee. The committee chair position is occupied by a member of the NC State faculty, and rotates every 3 years; the current chairperson is Dr. Michael Nolan.
Please contact any of us with any questions or concerns you have about the X-RAD machinery!
Javid Mohammed, firstname.lastname@example.org, 919.513.6443 (p)
Michael Nolan, email@example.com, 919.513.6487 (p)
Kate Meurs, firstname.lastname@example.org, 919.513.6213 (p)