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COVID-19 Update: The NC State Veterinary Hospital is expanding services, but still only seeing a limited number of cases at this time. Click to learn more about appointments.

Research Irradiation Core Facility

The X-RAD 320 is a self-contained X-ray system for delivering a precise radiation dosage to specimens in a biological or small animal research laboratory. The shielded cabinet includes an adjustable specimen shelf, sample-viewing window and beam hardening filter holder.

The TouchRAD control panel is a multi-user, password protected touch screen interface with a transportable database that can track individual system usage. A super-user controls passwords, programmed exposure settings, and database management.

The X-ray tube is used specifically for radiation therapy having a highly homogenous beam. Options available include dose measurement & control, motorized specimen shelf, turntable, fixed beam collimators, adjustable collimator, and specimen holding fixtures.

X-RAD 320

The NC State Veterinary Hospital has a clinical linear accelerator that is also available for research use. Interested users may seek consultation with one of the CVM Radiation Oncologists (Dr. Mike Nolan, Dr. Tracy Gieger, or Dr. Hiroto Yoshikawa).

Use rates are currently being approved by the University; for budgeting purposes, please use the following estimates:

Service (per hour) NCSU External Academic External Commercial
Consultation $90 $110 $130
X-RAD 320XL unassisted $60 -- --
X-RAD 320XL unassisted with anesthesia $75 -- --
X-RAD 320XL assisted $100 $115 $145
X-RAD 320XL assisted with anesthesia $115 $130 $160

Note:
  • Unassisted use is available to trained internal users.
  • External users must hire the core to perform irradiations – https://forms.gle/qJ9zXiMCc1gk3zBz6
  • Training will be free-of-charge during calendar year 2020; thereafter, 1 hour of consultation will be charged for training.

If you would like to schedule a time to use the X-RAD equipment, please reach out to Sarah Craven at cvmresearchoffice@ncsu.edu to be added to the X-RAD scheduler. Once you have access to the google calendar, you can book the equipment during open times.

PLEASE NOTE: only those who have gone through training can use the X-RAD machinery. You will be asked if you have completed the proper training before being granted access to the calendar.

Project Approvals and Radiation Safety Oversight

All research projects involving the irradiator must be approved by the NC State Radiation Safety Office. This includes vetting of the proposed research by the Radiation Safety Committee’s subcommittee for research at the College fo Veterinary Medicine. Such review is automatically included in the process of acquiring BUA and/or IACUC approval. If your project does not involve or require BUA/IACUC approval, please contact the Radiation Safety office to discuss an alternate route for project approval.

Development of New Irradiation Protocols

Researchers are able to deliver radiation once a new protocol has been established in the X-RAD device. This requires calibration, and programming of the device; that process can only be performed by a “Super User”, generally a Core Facility Manager. Dr. Nolan is also available to assist with protocol development (e.g., design of new/complicated irradiation procedures; troubleshooting; etc.).

Training and approval for independent operation of the X-RAD device involves a multi-step process:
  1. Complete the NC State University CVM Irradiator Access Form, found at: https://forms.gle/PSrzBfG1q5QTziRk9. Once the form is completed, it will be reviewed by both the Radiation Safety Office, and the PI of record for the irradiator. You will then be assigned to the necessary training course (# ehps-rs210 in NCSU Reporter) — that course is not public, so you cannot search for it — instead, you will receive an email with a link to the course.
  2. Upon completion of the training course, print the Competency Checklist (available via REPORTER) and arrange for Mr. Javid Mohammed to go through it with you and sign off on you being a “User”.
  3. Mr. Mohammed will then approve you as a user, which will prompt our system to give you swipe card access to the room where the irradiator is housed. Note that completion of this approval process may take up to five business days.
Please note that refresher training for the basic radiation safety course will be required every four years.

Location:

X-RAD Cell Radiation Core Facility

CVM Main Building, Room F123

North Carolina State University – College of Veterinary Medicine

Raleigh, NC 27607

Advisory Committee:

The Research Irradiation Core Facility is led by a committed scientific director (Dr. Kathryn Meurs), and two experienced core facility managers (Ms. Maria Stone and Mr. Javid Mohammed). An Advisory Committee has been formed to provide advice and oversight regarding Facility management and operations. The committee includes 4 volunteer members, each with a minimum term commitment of 3 years. The NC State Radiation Safety office has permanent representation on this committee. The committee chair position is occupied by a member of the NC State faculty, and rotates every 3 years; the current chairperson is Dr. Michael Nolan.

Contacts:

Please contact any of us with any questions or concerns you have about the X-RAD machinery!

Javid Mohammed, jpmohamm@ncsu.edu, 919.513.6443 (p)

Michael Nolan, mwnolan@ncsu.edu, 919.513.6487 (p)

Kate Meurs, cvmresearchoffice@ncsu.edu, 919.513.6213 (p)