Troy Ghashghaei

Bio

Troy Ghashghaei, originally from Iran, embarked on a new chapter in the United States in the early 1980s. He earned his Ph.D. from Boston University, followed by postdoctoral research at UNC-Chapel Hill, before joining the College of Veterinary Medicine in 2006. Since 2010, his laboratory has received ongoing funding from the NIH.

The Ghashghaei Lab is dedicated to unraveling the fundamental molecular, cellular, and physiological mechanisms of neurogenesis and gliogenesis in the embryonic, early postnatal, and adult forebrain. Currently, the lab is exploring perinatal developmental events with unprecedented cellular and molecular precision. Utilizing advanced mouse genetics, they investigate the roles of domain-specific progenitors and the destinies of their progeny during the critical period of forebrain development.

Dr. Ghashghaei has mentored numerous undergraduate, graduate, and postdoctoral fellows, all of whom have secured esteemed positions in academia and industry. He teaches neurophysiology within the DVM curriculum and has welcomed several DVM scholars to engage in research, fostering the next generation of scientists.

Website

https://ghashghaeilab.wordpress.ncsu.edu

Affiliations

Society for Neuroscience
American Society for Cell Biology
International Society for Stem Cell Research

Area(s) of Expertise

Mouse Genetics
Molecular Biology
Neurobiology
Developmental Biology
Imaging
Mouse Behavior

Publications

• Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain , ISCIENCE (2023)
• COMBINe enables automated detection and classification of neurons and astrocytes in tissue-cleared mouse brains , CELL REPORTS METHODS (2023)
• Deep learning-based adaptive optics for light sheet fluorescence microscopy , BIOMEDICAL OPTICS EXPRESS (2023)
• Illumination angle correction during image acquisition in light-sheet fluorescence microscopy using deep learning , BIOMEDICAL OPTICS EXPRESS (2022)
• Phosphorylation-dependent proteome of Marcks in ependyma during aging and behavioral homeostasis in the mouse forebrain , GEROSCIENCE (2022)
• Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy , BIOMEDICAL OPTICS EXPRESS (2021)
• Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy: publishers note (vol 12, pg 5214, 2021) , BIOMEDICAL OPTICS EXPRESS (2021)
• Detection and classification of neurons and glial cells in the MADM mouse brain using RetinaNet , PLOS ONE (2021)
• Ependyma-expressed CCN1 restricts the size of the neural stem cell pool in the adult ventricular-subventricular zone , EMBO JOURNAL (2020)
• Sp2 regulates late neurogenic but not early expansive divisions of neural stem cells underlying population growth in the mouse cortex , DEVELOPMENT (2020)

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