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Derek Foster, DVM, PhD, DACVIM

Assistant Professor, Ruminant Health Management

Contact:

derek_foster@ncsu.edu
Office: 919.513.6128

Dr. Derek Foster is an Assistant Professor of Ruminant Health and Production in the Department of Population Health and Pathobiology at North Carolina State University College of Veterinary Medicine. His research is focused on the transport mechanisms of large molecules including antimicrobials across the intestinal barrier. A better understanding of these mechanisms of drug movement into the gastrointestinal tract has the potential to allow veterinarians to mitigate negative impacts of systemically administered antimicrobials including antibiotic-associated diarrhea and selection of antimicrobial resistant fecal organisms. Further, increased knowledge of these mechanisms may allow for development of future drugs that specifically target a limited region of the intestine or do not penetrate the GI tract at all. Derek has developed both an in vivo model in cattle and an ex vivo model to assess this movement of antimicrobials into the intestine that can be translated to other large animal species. He also investigated methods of measuring active antibiotic concentrations at the site of infection including the airway and interstitial fluid to predict antibiotic efficacy. Additional interests include colostrum management and infectious diarrhea in calves.

Derek received his Doctor of Veterinary Medicine degree from NC State University College of Veterinary Medicine in 2004, and was an intern in Food Animal Medicine and Surgery at the Colorado State University College of Veterinary Medicine and Biomedical Sciences. Then, he returned to NC State for a residency in Large Animal Internal Medicine and a PhD in Gastrointestinal Physiology. He became boarded in Large Animal Internal Medicine in 2007 and completed his PhD in 2012. Dr. Foster was named the American Veterinary Medical Association Young Investigator of the year in 2011, and received the Pfizer Distinguished Veterinary Teaching Award in 2012.
Affiliations
American Association of Bovine Practitioners
Certifications
Diplomate, American College of Veterinary Internal Medicine (Large Animal)
PhD in gastrointestinal physiology
Biological Barriers, Gastroenterology, Infectious Diseases, Pharmacology
Antimicrobial resistance, food animal pharmacology, gastrointestinal physiology.
  • (2016) Comparison of Active Drug Concentrations in the Pulmonary Epithelial Lining Fluid and Interstitial Fluid of Calves Injected with Enrofloxacin, Florfenicol, Ceftiofur, or TulathromycinFoster DM, Martin LG, Papich MG | PLOS One 2016 Feb. 11(2):e0149100
  • (2016) Pharmacokinetics of enrofloxacin and ceftiofur in plasma, interstitial fluid, and gastrointestinal tract of calves after subcutaneous injection, and bactericidal impacts on representative enteric bacteriaFoster DM, Jacob ME, Warren CD, Papich MG | J Vet Pharmcol Ther 2016; 39(1):62-71
  • (2009) Third-compartment cannulation in alpacas using a polyurethane gastrostomy tube.GW Smith, MP Gerard, NB Campbell, DM Foster, SM Smith and JL Davis | Aust Vet J 510:487-491
  • (2007). Absorption of protein and immunoglobulin G in calves fed a colostrum replacer.Smith, GW, and Foster, DM. | J Dairy Sci 90:2905-2908.
  • Pathophysiology of Diarrhea in CalvesFoster DM and Smith GW.  | Veterinary Clinics of North America—Food Animal Practice. 2009; 25(1):13-36.
  • Characterization of passive immunity stimulated by vaccination of dry cows with a Salmonella bacterin.Smith GW, Alley ML, Foster DM, Smith F, Wileman BW. | J Vet Intern Med. Submitted for publication.
  • Prevalence and relatedness of E. coli O157:H7 in the feces and on the hides and carcasses of U. S. meat goats at slaughter.Jacob ME, Foster DM, Rogers AT, et al. | Applied and Environ Microbio. Accepted for publication
  • Characterization of passive immunity stimulated by vaccination of dry cows with a Salmonella bacterin.Smith GW, Alley ML, Foster DM, Smith F, Wileman BW. | J Vet Intern Med. Submitted for publication.
  • Prevalence and relatedness of Escherichia coli O157:H7 strains in the feces and on the hides and carcasses of US meat goats at slaughter.Jacob ME, Foster DM, Rogers AT, Balcomb CC, Sanderson MW. | Appl Environ Microbiol. 2013; 79(19):4154-8
  • Prevalence and relatedness of E. coli O157:H7 in the feces and on the hides and carcasses of U. S. meat goats at slaughter.Jacob ME, Foster DM, Rogers AT, et al. | Applied and Environ Microbio. Accepted for publication
  • Pathophysiology of Diarrhea in Calves | 2009; 25(1):13-36.
  • (2015) Short communication: Characterization of the serologic response induced by vaccination of late-gestation cows with a Salmonella Dublin vaccineSmith GW, Smith F, Zuidhof S, Foster DM | J Dairy Sci. 2015 Apr; 98(4):2529-32
  • (2014) Passive immunity stimulated by vaccination of dry cows with a Salmonella bacterial extractplantation of an ultrafiltration.Smith GW, Alley ML, Foster DM, Smith F, Wileman BW | dJ Vet Intern Med. 2014; 28(5):1602-5
  • (2014) Implantation of an ultrafiltration device in the ileum and spiral colon of steers to continuously collect intestinal fluid.Warren CD, Prange T, Campbell NB, Gerard MP, Martin LG, Jacob ME, Smith GW, Papich MG, Foster DM | Res Vet Sci. 2014; 97(3):611-5
  • (2013) Evidence of non-O157 Shiga toxin-producing Escherichia coli in the feces of meat goats at a U. S. slaughter plant.Jacob ME, Foster DM, Rogers AT, Balcomb CC, Shi X, Nagaraja TG. | J Food Protect. 2013; 76(9):1626-9
  • (2013) Prevalence and relatedness of Escherichia coli O157:H7 strains in the feces and on the hides and carcasses of US meat goats at slaughter.Jacob ME, Foster DM, Rogers AT, Balcomb CC, Sanderson MW. | Appl Environ Microbiol. 2013; 79(19):4154-8
  • (2012) Proteasome inhibition of pathologic shedding of enterocytes to defend barrier function requires X-linked inhibitor of apoptosis protein and nuclear factor-κB.Foster DM, Stauffer SH, Stone MR, Gookin JL. | Gastroenterology. 2012; 143:133-44. A figure from this manuscript was chosen for the cover.
  • (2011) Acute necrotizing enterocolitis of preterm piglets is characterized by a unique consortium of ileum-associated bacteria. Azcarate-Peril MA, Foster DM, Cadenas MA, Stone MR, Jacobi SK, Stauffer SH, Pease A, Gookin JL. | Gut Microbes. 2011; 2(4):234-43. A figure from this manuscript was chosen for the cover.
  • (2011) Efficacy of amprolium for the treatment of pathogenic Eimeria species in Boer goat kids. Young G, Smith GW, Alley ML, Foster DM.  | Vet Parasit. 2011; 178(3-4):346-9
  • (2011) Congenital pericardeoperitoneal diaphragmatic hernia in an alpacaFoster DM, Chinnadauri S, Nutt J, Pandiri A, Linder K, Alley M, Smith GW. | Aust Vet J. 2011; 89(1-2):51-4.
  • (2010) Efficacy and pharmacokinetics of pantoprazole in alpacas.Smith, G.W., Davis, J.L., Smith, S.M., Gerard, M.P., Campbell, N.B., Foster, D.M. | J Vet Intern Med. 24:949-955
  • (2009) An animated model of reticulorumen motility. Gookin JL, Foster DM, Harvey AM, McWhorter D.  | J Vet Med Educ.  2009; 36(4):444-50
  • (2009) Third compartment cannulation in alpacas using a polyurethane gastrotomy tubeSmith GW, Gerard MP, Campbell NB, Foster DM, et al. | Aust Vet J. 2009; 87(12):487-91
  • (2008) Posterior paresis resulting from a vertebral body fracture in a bull.Foster, D.M., Smith, G.W., Pandiri, A., and Blond L. | Bovine Practitioner 2008; 42(1):41-4
  • (2008) Oral delivery of L-arginine stimulates prostaglandin-dependent secretory diarrhea in C. parvum infected neonatal piglets.Gookin JL, Foster DM, Coccaro MR, Stauffer SH | J Pediatr Gastroenterol Nutr. 2008; 46:139-146
  • (2007) Pharmacokinetics and tissue distribution of enrofloxacin and the metabolite ciprofloxacin in calves.Davis JL, Foster DM, Papich M | J Vet Pharmacol Ther. 2007; 30(6):564-571
  • (2007) Absorption of protein and IgG in calves fed a colostrum replacer.Smith GW and Foster DM | J Dairy Sci. 2007; 90:2905-2908
  • (2006) Serum IgG and total protein concentrations in dairy calves fed two colostrum replacement products.Foster, DM, Smith, G, Sanner, TR, and Busso, GV. | J Am Vet Med Assoc. 229:1282-1285
  • (2004) Outcome of cats with diarrhea and Tritrichomonas foetus infection.Foster DM, Gookin JL, Poore MF, Stebbins ME, Levy MG | J Am Vet Med Assoc. 2004; 225:888-892
  • (2003) Use of a commercially available culture system for diagnosis of Tritrichomonas foetus infection in cats.Gookin JL, Foster DM, Poore MF, Stebbins ME, Levy MG | J Am Vet Med Assoc. 2003; 222:1376-79

'One Medicine' Pilot Studies at College of Veterinary Medicine Help Uncover Genetic Basis of Disease

New discoveries are being made daily in the field of genomics—the study of the genetic basis of disease and health—that have the potential to create new and effective treatments for many complex diseases plaguing both people and animals. Modern technology, for example, allows researchers to identify, or map, diseases to specific regions of chromosomes. Sequencing