Troy Ghashghaei
Bio
I have a broad background in the field of neuroscience, with specific training and more recently independent expertise in developmental neurobiology. My graduate work at Boston University was focused on mapping prefrontal cortical circuits that allow this critical brain structure to communicate with emotional centers of the brain. I followed my Ph.D thesis with a very productive postdoctoral experience at UNC-Chapel Hill, with the first report of the role of Neuregulins and their tyrosine kinase receptors on adult neurogenesis and neuronal migration in the postnatal brain, and subsequent reports on related findings in high-impact journals. I established my own laboratory at NC State’s College of Veterinary Medicine in 2006, where I have laid the groundwork for currently ongoing research in my laboratory. This required development of critical tools and research methods to assess the role of genes in development and function of neural stem cells. My laboratory has obtained a number of grants in support of our research efforts and my students and postdoctoral fellows have all obtained excellent positions following completion of their work here at NC State. The focus of our current research is on embryonic and postnatal epithelial lining of the brain and how it contributes to development in the embryo and homeostasis during adulthood and aging.
AFFILIATIONS
Society for Neuroscience
American Society for Cell Biology
International Society for Stem Cell Research
Area(s) of Expertise
BIOLOGICAL BARRIERS, COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, GENETICS, NEUROBIOLOGY, REGENERATIVE MEDICINE
Projects in our laboratory are focused on developmental neurobiology:
1. Development and aging of the adult stem cells and their ependymal niche in the forebrain. We use mouse genetics in combination with molecular, biochemical, and cell biological approaches to address fundamental questions regarding the functional significance of ependymal cells during development and aging.
2. Role of cell cycle regulators in symmetric and asymmetric divisions of neural stem cells in the developing and postnatal brain. We use mouse genetics, biochemical assays, and state-of-the-art imaging tools to understand mechanisms that regulate the decision of neural stem cells to divide symmetrically or asymmetrical in the embryonic and postnatal stem cell niches.
Publications
- Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain , ISCIENCE (2023)
- COMBINe enables automated detection and classification of neurons and astrocytes in tissue-cleared mouse brains , CELL REPORTS METHODS (2023)
- Deep learning-based adaptive optics for light sheet fluorescence microscopy , BIOMEDICAL OPTICS EXPRESS (2023)
- Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy: publishers note (vol 12, pg 5214, 2021) , BIOMEDICAL OPTICS EXPRESS (2022)
- Illumination angle correction during image acquisition in light-sheet fluorescence microscopy using deep learning , BIOMEDICAL OPTICS EXPRESS (2022)
- Phosphorylation-dependent proteome of Marcks in ependyma during aging and behavioral homeostasis in the mouse forebrain , GEROSCIENCE (2022)
- Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy , BIOMEDICAL OPTICS EXPRESS (2021)
- Detection and classification of neurons and glial cells in the MADM mouse brain using RetinaNet , PLOS ONE (2021)
- Ependyma-expressed CCN1 restricts the size of the neural stem cell pool in the adult ventricular-subventricular zone , EMBO JOURNAL (2020)
- Sp2 regulates late neurogenic but not early expansive divisions of neural stem cells underlying population growth in the mouse cortex , DEVELOPMENT (2020)
Groups
- Research Area of Emphasis: Biological Barriers
- Research Area of Emphasis: Computational Biology and Bioinformatics
- CVM
- Developmental Biology
- CVM: Focus Area
- Research Area of Emphasis: Genetics
- Focus Area: Graduate Cell Biology
- Molecular Biomedical Sciences: MBS Faculty
- Molecular Biomedical Sciences: MBS Researchers
- CVM: Molecular Biomedical Sciences
- Research Area of Emphasis: Neurobiology
- Research Area of Emphasis: Regenerative Medicine
- CVM: Research Area of Emphasis
News
- Cheng, Ghashghaei Selected as University Faculty Scholars
- When Neurons are ‘Born’ Impacts Olfactory Behavior in Mice
- NC State Researcher Finds MARCKS Protein May Help Protect Brain Cells from Age Damage
- Neural Transplant Reduces Absence Epilespsy Seizures in Mice
- Researchers Find Lack of Protein Sp2 Disrupts Neuron Creation in Brain