Susan Tonkonogy

Bio

Education:

Douglass College, Rutgers University
New Brunswick, NJ
BA (Bacteriology) 1970

Harvard University
Cambridge, MA
Ph.D. (Immunology) 1976

Positions:

Research Assistant, Department of Bacteriology and Immunology, Harvard Medical School, Boston, MA, 1970-1971

Postdoctoral Fellow, Department of Immunology, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland, 1977-1979

Temporary Advisor, World Health Organization Research and Training Institute, Instituto Butantan, Sao Paulo, Brazil (taught immunology course), 1979

Postdoctoral Fellow, Division of Immunology, Duke University Medical Center, Durham, NC, 1979-1980

Medical Research Associate, Division of Immunology, Duke University Medical Center, Durham, NC, 1980-1982

Assistant Professor, Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 1982-1988

Associate Professor, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 1988-present

Director, Immunology Graduate Program, North Carolina State University, Raleigh, NC, 2006-2011

Director, Gnotobiotic Animal Core, Center for Gastrointestinal Biology and Disease, North Carolina State University and University of North Carolina at Chapel Hill, 2000-present

Area(s) of Expertise

IMMUNOLOGY
My current research focuses on cytokine mediated regulation of immunity and inflammation in the intestinal tract. Our studies are designed to determine how the intestinal immune response is involved in initiation and perpetuation of chronic intestinal inflammation that occurs in human inflammatory bowel disease.

Publications

• IgD(+) age-associated B cells are the progenitors of the main T-independent B cell response to infection that generates protective Ab and can be induced by an inactivated vaccine in the aged , AGING CELL (2022)
• Microbiome Shapes the T Cell Receptor Repertoire among CD4+CD8+ Thymocytes , BIOMEDICINES (2022)
• Murine Adherent and Invasive E. coli Induces Chronic Inflammation and Immune Responses in the Small and Large Intestines of Monoassociated IL-10(-/-) Mice Independent of Long Polar Fimbriae Adhesin , INFLAMMATORY BOWEL DISEASES (2019)
• Transient activation of mucosal effector immune responses by resident intestinal bacteria in normal hosts is regulated by interleukin-10 signalling , IMMUNOLOGY (2016)
• Molecular detection of bacterial contamination in gnotobiotic rodent units , Gut Microbes (2013)
• Antigen-Presenting Cell Production of IL-10 Inhibits T-Helper 1 and 17 Cell Responses and Suppresses Colitis in Mice , GASTROENTEROLOGY (2011)
• Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation , GASTROENTEROLOGY (2011)
• Adaptation in a Mouse Colony Monoassociated with Escherichia coli K-12 for More than 1,000 Days , APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2010)
• Bifidobacterium animalis causes extensive duodenitis and mild colonic inflammation in monoassociated interleukin-lO-deficient mice , Inflammatory Bowel Diseases (2009)
• Endogenous antigen presenting cell-derived IL-10 inhibits T lymphocyte responses to commensal enteric bacteria , IMMUNOLOGY LETTERS (2009)

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