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Susan Tonkonogy, PhD

Associate Professor, Microbiology and Immunology

Contact:

suet@ncsu.edu
Office: 919.513.6252
Lab: Gastrointestinal Biology and Disease
Lab Phone: 919.513.6252

Education:

Douglass College, Rutgers University
New Brunswick, NJ
BA (Bacteriology) 1970

Harvard University
Cambridge, MA
Ph.D. (Immunology) 1976

Positions:

Research Assistant, Department of Bacteriology and Immunology, Harvard Medical School, Boston, MA, 1970-1971

Postdoctoral Fellow, Department of Immunology, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland, 1977-1979

Temporary Advisor, World Health Organization Research and Training Institute, Instituto Butantan, Sao Paulo, Brazil (taught immunology course), 1979

Postdoctoral Fellow, Division of Immunology, Duke University Medical Center, Durham, NC, 1979-1980

Medical Research Associate, Division of Immunology, Duke University Medical Center, Durham, NC, 1980-1982

Assistant Professor, Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 1982-1988

Associate Professor, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 1988-present

Director, Immunology Graduate Program, North Carolina State University, Raleigh, NC, 2006-2011

Director, Gnotobiotic Animal Core, Center for Gastrointestinal Biology and Disease, North Carolina State University and University of North Carolina at Chapel Hill, 2000-present
Immunology
My current research focuses on cytokine mediated regulation of immunity and inflammation in the intestinal tract. Our studies are designed to determine how the intestinal immune response is involved in initiation and perpetuation of chronic intestinal inflammation that occurs in human inflammatory bowel disease.

  • Molecular Detection of Bacterial Contamination in Gnotobiotic Rodent Units,Packey CD, Shanahan MT, Manick S, Bower MA, Ellermann M, Tonkonogy SL, Carroll IM and Sartor RB.  | Gut Microbes. 2013 Jul 24;4(5).
  • 2011. IL-10 produced by antigen presenting cells inhibits bacterial-responsive TH1/TH17 cells and suppresses colitis in mice.Liu B, Tonkonogy SL, Sartor RB. | Gastroenterology 141:653-62.
  • 2011. Bacterial proteases contribute to intestinal inflammation by impairing mucosal barrier function in the susceptible host.Steck N, Hoffmann M, Irina S, Kim S, Hahne H, Tonkonogy SL, Mair K, Krueger D, Pruteanu M, Shanahan F, Vogelmann R, Schemann M, Küster B, Sartor RB, Haller D. | Gastroenterology 141:959-71.
  • 2010. Adaptation in a mouse colony monoassociated with Escherichia coli K-12 for more than 1000 days.Lee SM, Wyse A, Lesher A, Everett ML, Lou L, Holzknecht ZE, Whitesides JF, Spears PA, Bowles DE, Lin SS, Tonkonogy SL, Orndorff PE, Bollinger RR, Parker W. | Appl Environ Microbiol. 76:4655-63.
  • 2009 Endogenous antigen presenting cell-derived IL-10 inhibits T lymphocyte responses to commensal enteric bacteria.Albright CA, Sartor RB, Tonkonogy SL. | Immunol Lett 123:77-87.
  • 2009. Bifidobacterium animalis causes extensive duodenitis and mild colonic inflammation in monoassociated interleukin-10 deficient mice.Moran JP, Walter J, Tannock GW, Tonkonogy SL, Sartor RB. | Inflamm Bowel Dis 15:1022-1031.
  •  2008. Reduced responsiveness of HLA-B27 transgenic rat cells to TGF-b and IL-10-mediated regulation of IFN-g production.Qian B-F, Tonkonogy SL, and Sartor RB. | Inflamm Bowel Dis 14:921-30.
  • 2008. Aberrant innate immune responses in TLR-ligand activated HLA-B27 transgenic rat cells.Qian B-F, Tonkonogy SL, Sartor RB.  | Inflamm Bowel Dis 14:1358-65.
  • 2007. CD4+ T lymphocytes mediate colitis in HLA-B27 transgenic rats monoassociated with non-pathogenic Bacteroides vulgatus.Hoentjen F, Tonkonogy SL, Qian B-F, Liu B, Dieleman LA, Sartor RB.  | Inflamm Bowel Dis. 13:317-24.
  • 2007 Bacterial symbionts induce a FUT2-dependent fucosylated niche on colonic epithelium via ERK and JNK signaling.Meng D, Newburg DS, Young C, Baker A, Tonkonogy SL, Sartor RB, Walker WA, Nanthakumar NN. | Am J Physiol Gastrointest Liver Physiol. 293:G780-7.
  • 2007. Dual-association of gnotobiotic IL-10-/- mice with two non-pathogenic commensal bacteria induces aggressive pancolitis.Kim SC, Tonkonogy, SL, Karrasch T, Jobin C, Sartor RB. | Inflamm Bowel Dis. 13:1457-66.
  • 2006. Luminal bacterial antigen-specific CD4+ T cell responses in HLA-B27 transgenic rats with chronic colitis are mediated by both MHC Class II and HLA-B27 molecules.Qian B-F, Tonkonogy SL, Sartor RB. | Immunology, 117:319-28.
  • 2006. Adoptive transfer of non-transgenic mesenteric lymph node cells induces colitis in athymic HLA-B27 transgenic nude rats.Hoentjen F, Tonkonogy SL, Liu B, Sartor RB, Taurog JD, Dieleman LA. | Clinical and Experimental Immunology, 143:474-82.
  • 2005. Variable phenotypes of enterocolitis in IL-10 deficient mice monoassociated with two different commensal bacteria.Kim SC, Tonkonogy SL, Albright CA, Tsang J, Balish EJ, Braun J, Huycke MM, Sartor RB. | Gastroenterology 128:891-906.
  • 2005. Dysregulated luminal bacterial antigen-specific T cell responses and antigen presenting cell function in HLA-B27 transgenic rats with chronic colitis. Qian B-F, Tonkonogy SL, Hoentjen F, Dieleman LA, Sartor RB. | Immunology 116:112-21.
  • 2004. Reduced ratio of protective versus proinflammatory cytokine responses to commensal bacteria in HLA-B27 transgenic rats.Dieleman LA, Hoentjen F, Qian B-F, Sprengers D, Tjwa E, Torres MF, Torrice CD, Sartor RB, Tonkonogy SL. | Clin Exp Immunol. 136:30-9.
  • 2011. IL-10 produced by antigen presenting cells inhibits bacterial-responsive TH1/TH17 cells and suppresses colitis in mice.Liu B, Tonkonogy SL, Sartor RB. | Gastroenterology 141:653-62.
  • 2011. Bacterial proteases contribute to intestinal inflammation by impairing mucosal barrier function in the susceptible host. | Gastroenterology 141:959-71.
  • 2010. Adaptation in a mouse colony monoassociated with Escherichia coli K-12 for more than 1000 days.Lee SM, Wyse A, Lesher A, Everett ML, Lou L, Holzknecht ZE, Whitesides JF, Spears PA, Bowles DE, Lin SS, Tonkonogy SL, Orndorff PE, Bollinger RR, Parker W. | Appl Environ Microbiol. 76:4655-63.
  • 2009 Endogenous antigen presenting cell-derived IL-10 inhibits T lymphocyte responses to commensal enteric bacteria.Albright CA, Sartor RB, Tonkonogy SL. | Immunol Lett 123:77-87.
  • 2009. Bifidobacterium animalis causes extensive duodenitis and mild colonic inflammation in monoassociated interleukin-10 deficient mice.Moran JP, Walter J, Tannock GW, Tonkonogy SL, Sartor RB. | Inflamm Bowel Dis 15:1022-1031.
  • 2008. Aberrant innate immune responses in TLR-ligand activated HLA-B27 transgenic rat cells. | Inflamm Bowel Dis 14:1358-65.
  • 2007. CD4+ T lymphocytes mediate colitis in HLA-B27 transgenic rats monoassociated with non-pathogenic Bacteroides vulgatus. | Inflamm Bowel Dis. 13:317-24.
  • 2007 Bacterial symbionts induce a FUT2-dependent fucosylated niche on colonic epithelium via ERK and JNK signaling.Meng D, Newburg DS, Young C, Baker A, Tonkonogy SL, Sartor RB, Walker WA, Nanthakumar NN. | Am J Physiol Gastrointest Liver Physiol. 293:G780-7.
  • 2007. Dual-association of gnotobiotic IL-10-/- mice with two non-pathogenic commensal bacteria induces aggressive pancolitis.Kim SC, Tonkonogy, SL, Karrasch T, Jobin C, Sartor RB. | Inflamm Bowel Dis. 13:1457-66.
  • 2006. Luminal bacterial antigen-specific CD4+ T cell responses in HLA-B27 transgenic rats with chronic colitis are mediated by both MHC Class II and HLA-B27 molecules.Qian B-F, Tonkonogy SL, Sartor RB. | Immunology, 117:319-28.
  • 2006. Adoptive transfer of non-transgenic mesenteric lymph node cells induces colitis in athymic HLA-B27 transgenic nude rats.Hoentjen F, Tonkonogy SL, Liu B, Sartor RB, Taurog JD, Dieleman LA. | Clinical and Experimental Immunology, 143:474-82.
  • 2005. Variable phenotypes of enterocolitis in IL-10 deficient mice monoassociated with two different commensal bacteria.Kim SC, Tonkonogy SL, Albright CA, Tsang J, Balish EJ, Braun J, Huycke MM, Sartor RB. | Gastroenterology 128:891-906.
  • 2004. Reduced ratio of protective versus proinflammatory cytokine responses to commensal bacteria in HLA-B27 transgenic rats.Dieleman LA, Hoentjen F, Qian B-F, Sprengers D, Tjwa E, Torres MF, Torrice CD, Sartor RB, Tonkonogy SL. | Clin Exp Immunol. 136:30-9.
  • Molecular Detection of Bacterial Contamination in Gnotobiotic Rodent Units, | Gut Microbes. 2013 Jul 24;4(5).