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Profile

Karen Munana, DVM, MS, DACVIM (Neurology)

Professor, Neurology

Contact:

krmunana@ncsu.edu
Office: 919.513.6231
Lab: Companion Animal Epilepsy
Lab Phone: 919.513.6812

Dr. Muñana obtained her veterinary degree from the University of California at Davis. She went on to complete a rotating internship in small animal medicine and surgery at Kansas State University and a residency training program in neurology and neurosurgery at Colorado State University. She joined the faculty at NC State College of Veterinary Medicine in 1996.
Affiliations
Member, International Veterinary Epilepsy Task Force
Certifications
Diplomate, American College of Veterinary Internal Medicine (Neurology)
Spontaneous Animal Disease Models
Canine epilepsy- with focus on causes of refractory (poorly controlled) epilepsy and development of more effective treatments for dogs with seizures.

Encephalitis - studies into potential causes, diagnosis and treatment of inflammatory brain disease in dogs and cats

CLINICAL STUDIES
  • (2017) The effect of cranberry extract on the frequency of bacteriuria in dogs following acute thoracolumbar disc herniation: a randomized controlled clinical trial.Olby NJ, Vaden S, Williams K, Griffith E, Harris T, Mariani C, Munana K, Early P, Platt S, Boozer L, Giovanella C, Longshore R. | J Vet Intern Med, In Press.
  • (2016) A Placebo-Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disk Herniation.Olby NJ, Muguet-Chanoit, Lim JH, Davidian M, Mariani CL, Freeman AC, Platt SR, Humphrey J, Kent M, Giovanella C, Longshore R, Early PJ, Muñana KR | Journal of Veterinary Internal Medicine 2016 Jan;30(1):206-14
  • (2016) 2015 ACVIM Consensus Statement on Canine Seizure Management.Podell M, Volk H, Berendt M, Loescher W, Muñana K, Patterson E, Platt S. | Journal of Veterinary Internal Medicine 2016; epub ahead of print.
  • (2016) Evaluation of the Impacts of Epilepsy in Dogs on Caregivers.Nettifee, JA, Muñana KR | Journal of the American Animal Hospital Association Approved, 2016
  • (2015) Effect of chronic administration of phenobarbital or bromide on pharmacokinetics of levetiracetam in dogs with epilepsy.Muñana KR, Nettifee-Osborne J, Papich MG. | Journal of Veterinary Internal Medicine 2015; 2:614-619.
  • (2015) International Veterinary Epilepsy Task Force recommendations for systemic sampling and processing of brains from epileptic dogs and cats.Matiasek K, Pumarola M, Rosati M, Fernandez-Flores F, Fischer A, Wagner E, Berendt M, Bhatti S, De Risio L, Farquhar R, Long S, Muñana K, Patterson E, Pakozdy A, Penderis J, Platt S, Podell M, Potschka H, Rusbridge C, Stein V, Tipold A, Volk H. | BMC Veterinary Research 2015; 11:216. doi:10.1186/s12917-015-0467-9
  • (2015) International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol.Rusbridge C, Long S, Jovanovik J, Milne M, Berendt M, Bhatti S. De Risio L, Farquhar R, Fischer A, Matiasek K, Muñana K, Patterson E, Pakozdy A, Penderis J, Platt S, Podell M, Potschka H, Stein V, Tipold A, Volk H. | BMC Veterinary Research 2015; 11:194. doi:10.1186/s12917-015-0466-x
  • (2015) International Veterinary Epilepsy Task Force Consensus Proposal: Outcome of therapeutic interventions in canine and feline epilepsy.Potschka H, Fischer A, Loescher W, Patterson E, Bhatti S. Berendt M, De Risio L, Farquhar R, Long S, Mandigers P, Matiasek K, Muñana K, Pakozdy A, Penderis J, Platt S, Podell M, Rusbridge C, Stein V, Tipold A, Volk H. | BMC Veterinary Research 2015; 11:177. doi:10.1186/s12917-015-0465-y
  • (2015) International Veterinary Epilepsy Task Force consensus proposal: Diagnostic approach to epilepsy in dogs.De Risio L, Bhatti S, Muñana K, Penderis J, Stein V, Tipold A, Berendt M, Farquhar R, Fischer A, Long S, Loescher W, Mandigers P, Matissek K, Pakozdy A, Patterson E, Platt S, PodellM, Potschka H, Rusbridge C. Volk H. | BMC Veterinary Research 2015; 11:148. doi: 0.1186/s12917-015-0462-1
  • (2015) International Veterinary Epilepsy Task Force consensus proposal: Medical treatment of canine epilepsy in Europe.Bhatti S, De Risio L, Muñana K, Penderis J, Stein V, Tipold A, Berendt M, Farquhar R, Fischer A, Long S, Loescher W, Mandigers P, Matissek K, Pakozdy A, Patterson E, Platt S, PodellM, Potschka H, Rusbridge C. Volk H. | BMC Veterinary Research 2015; 11: 176. doi:10.1186/s12917-015-0464-z
  • (2015) International Veterinary Epilepsy Task Force consensus report on epilepsy definition, classification and terminology in companion animals.Berendt M, Farquhar R, Mandigers P, Pakozdy A, Bhatti S, De Risio L, Fischer A, Long S, Matsiaket K, Muñana K, Patterson E, Penderis J, Platt S, Podell M, Potschka H, Pumarola M, Rusbridge C, Stein V, Vold H, Tipold A. | BMC Veterinary Research 2015; 11:182. doi:10.1186/s12917-015-0461-2
  • (2013) Prevalence, clinical course and owner perception of dogs with cryptogenic epilepsy: 45 cases (2003-2011).Schwartz M, Muñana KR, Nettifee-Osborne J. | Journal of the American Veterinary Medical Association 2013; 242:651-657.
  • (2013) The pharmacokinetics of midazolam after intravenous, intramuscular and rectal administration in healthy dogs.Schwartz M, Muñana KR, Nettifee-Osborne JA, Messenger KM, Papich MG. | Journal of Veterinary Pharmacology and Therapeutics 2013; 36:471-477.
  • (2012) Evaluation of levetiracetam as adjunctive treatment for refractory canine epilepsy: A randomized, placebo-controlled, cross-over trial.Muñana KR, Thomas WB, Inzana KD, Nettifee-Osborne JA, McLucas KJ, Olby NJ, Mariani CM, Early PJ. | Journal of Veterinary Internal Medicine 2012; 26:341-348.
  • (2012) Association between ABCB1 genotype and seizure outcome in Collies with epilepsy.Muñana KR, Nettifee-Osborne JA, Bergman RL, Jr, Mealey KL. | Journal of Veterinary Internal Medicine 2012; 26:1358-1364.
  • (2012) Association between ABCB1 genotype and seizure outcome in Collies with epilepsy.Muñana KR, Nettifee-Osborne JA, Bergman RL Jr, Mealey KL. | J Vet Intern Med 2012 Nov-Dec;26(6):1358-64. doi: 10.1111/j.1939-1676.2012.01006.x. Epub 2012 Sep 24. PMID: 22998209
  • (2011) The pharmacokinetics of levetiracetam in healthy dogs concurrently receiving phenobarbital.Moore SA, Muñana KR, Papich MG, Nettifee-Osborne JA. | Journal of Veterinary Pharmacology and Therapeutics 2011; 34(1):31-34.
  • (2011) Pharmacokinetics of voriconazole after oral administration of single and multiple doses in African grey parrots (Psittacus erithacus timneh).Flammer K, Nettifee Osborne JA, Webb DJ, Foster LE, Dillard SL, Davis JL. | Am J Vet Res 2008 Jan;69(1):114-21. doi: 10.2460/ajvr.69.1.114. PMID: 18167096
  • (2010) Placebo effect in canine epilepsy trials.Muñana KR, Zhang D, Patterson EE. | Journal of Veterinary Internal Medicine 2010;24:166-170.
  • (2010) Levetiracetam pharmacokinetics in healthy dogs following single and multiple oral doses.Moore SA, Muñana KR, Papich MG, Nettifee-Osborne J. | American Journal of Veterinary Research 2010; 71:337-341.
  • (2010) The pharmacokinetics of levetiracetam in healthy dogs concurrently receiving phenobarbital.Moore SA, Muñana KR, Papich MG, Nettifee-Osborne JA. | Journal of Veterinary Pharmacology and Therapeutics, January 2010.
  • (2010) Prevalence of urinary tract infection in dogs after surgery for thoracolumbar intervertebral disc extrusion.Olby NJ, MacKillop E, Cerda-Gonzalez S, Moore S, Munana KR, Graffinger M, Osborne JA, Vaden SL. | J Vet Intern Med, 2010, 24:1112-1117.
  • (2009) Medical Management of Refractory Canine Epilepsy.Muñana KR. | Veterinary Medicine 2009; 104: 342-347.
  • (2009) Pharmacogenetic association study of 30 genes with phenobarbital drug response in epileptic dogs.Kennerly EM, Idaghdour Y, Olby NJ, Muñana KR, Gibson GC. | Pharmacogenetics and Genomics 2009; 19:911-922.
  • (2007) Beta 2-microglobulin levels in the cerebrospinal fluid of normal dogs and dogs with neurological disease.Muñana KR, Saito M, Hoshi F. | Veterinary Clinical Pathology 2007; 36:173-178.
  • (2006) Leading Edge - Management of refractory canine epilepsy.Muñana KR. | Veterinary Forum 2006; 23: 42-46.
  • (2004) Clinicopathologic abnormalities and treatment response in dogs seroreactive to Bartonella vinsonii subspecies berkhoffii antigens: a retrospective study.Blann K, Stebbins M, Muñana K, Davidson M, Jackson H, Willard M, Breitschwerdt E. | Journal of the American Animal Hospital Association 2004; 40:92-101.
  • (2003) Use of a multiplex polymerase chain reaction assay in the antemortem diagnosis of toxoplasmosis and neosporosis in the central nervous system of cats and dogs.Schatzberg SJ, Haley NJ, Barr SC, deLahunta A, Olby N, Muñana K, Sharp NJ. | American Journal of Veterinary Research 2003 Dec;64(12):1507-13.
  • (2002) The use of vagal nerve stimulation as a treatment for refractory epilepsy in dogs: a placebo-controlled, double blind, cross-over study.Muñana KR, Vitek SA, Tarver WB, Saito M, Skeen TM, Sharp NJH, Olby NJ, Haglund MM. | Journal of the American Veterinary Medical Association, 2002; 221:977-983.
  • (2002) Post-operative recovery and long term follow-up in 21 dogs undergoing dorsal laminectomy for caudal cervical spondylomyelopathy.De Risio L, Muñana K, Murray M, Olby N, Sharp N, Cuddon P. | Veterinary Surgery 2002;31:418-427.
  • (2001) Risk factors for development of status epilepticus in dogs with idiopathic epilepsy and effects of status epilepticus on outcome and survival time: 32 cases (1990-1996).Saito M, Muñana KR, Sharp NJH, Olby NJ. | Journal of the American Veterinary Medical Association 2001;219:618-623.
  • (2001) Infection of fetal feline brain cells in culture with Bartonella henselae.Muñana KR, Vitek SM, Hegarty BC, Kordick DL, Breitschwerdt EB. | Infection and Immunity 2001;69:564-569.
  • (2001) Intervertebral disc disease in 10 cats.Muñana KR, Olby NJ, Sharp NJH, Skeen T. | Journal of the American Animal Hospital Association 2001;37:384-389.
  • (1999) Acute-Onset Vestibular Disease.Muñana KR. | Compendium’s Standards of Care 1999; 1(8):1–5.
  • (1998) Evaluation of prognostic factors for canine granulomatous meningoencephalomyelitis: 42 cases (1982–1996).Muñana KR, Luttgen PJ. | Journal of the American Veterinary Medical Association 1998;212:1902–1906.
  • (1996) Feline ocular and cerebrospinal fluid Toxoplasma gondii-specific humoral immune responses following specific and nonspecific immune stimulation.Lappin MR, Chavkin MJ, Muñana KR, Cooper CM. | Veterinary Immunology and Immunopathology 1996;55:23–31.
  • (1995) Sequential measurement of Toxoplasma gondii-specific antibodies in the cerebrospinal fluid of cats with experimentally induced toxoplasmosis.Muñana KR, Lappin MR, Powell CC, Cooper CM, Chavkin MJ. | Progress in Veterinary Neurology 1995;6:27–31.
  • (1994) Toxoplasma gondii-specific antibodies in the aqueous humor of cats with toxoplasmosis.Chavkin MJ, Lappin MR, Powell CC, Cooper CM, Muñana KR. | American Journal of Veterinary Research 1994;55:1244–1249.
  • (1994) Neurologic manifestations of Niemann-Pick disease type C in cats.Muñana KR, Luttgen PJ, Thrall MA, Mitchell TW, Wenger DA. | Journal of Veterinary Internal Medicine 1994;8:117–121.