Michael W. Nolan, DVM, PhD, Diplomate ACVR (Radiation Oncology)
Associate Professor, Radiation Oncology and Biology
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AffiliationsMember, Radiation Research Society
Member, American Society for Radiation Oncology (ASTRO)
Member, Veterinary Cancer Society
Member, American College of Veterinary Radiology
Member, Comparative Medicine Institute, NC State
Member, North Carolina Veterinary Medical Association
Associate Member, Duke Cancer Institute
CertificationsDiplomate, American College of Veterinary Radiology (Radiation Oncology)
Neurobiology, Spontaneous Animal Disease ModelsNormal Tissue Radiobiology:
The fundamental aim of Dr. Nolan's research is to reduce discomfort and side effects in patients undergoing cancer treatment. In particular, the Nolan lab studies the complex molecular signaling pathways that are activated in patients experiencing radiotherapy-associated pain, and they are working hard to understand how pain signaling can influence tumor behavior. Such knowledge is critical to developing new therapies that will maximize both quality and quantity of life in pets and people with cancer.
Dr. Nolan is the lead investigator for a number of clinical trials in veterinary oncology. This allows for testing and development of novel cancer therapies.
- (2017) Outcomes of Spatially Fractionated Radiotherapy (GRID) for Bulky Soft Tissue Sarcomas in a Large Animal Model.Nolan MW, Gieger TL, Karakashian AA, Nikolova-Karakashian MN, Posner LP, Roback DM, Rivera JN, Chang S. | Technol Cancer Res Treat. 2017 Jan 1:1533034617690980. doi: 10.1177/1533034617690980. [Epub ahead of print]PMID: 28168937.
- (2017) Pilot study to determine the feasibility of radiation therapy for dogs with right atrial masses and hemorrhagic pericardial effusion.Nolan MW, Arkans MM, LaVine D, DeFrancesco T, Myers JA, Griffith EH, Posner LP, Keene BW, Tou SP, Gieger TL. | J Vet Cardiol. pii: S1760-2734(17)30033-4. doi: 10.1016/j.jvc.2016.12.001. [Epub ahead of print] Mar 7, 2017.
- (2017) Nocifensive behaviors in mice with radiation-induced oral mucositis.Nolan MW, Long CT, Marcus K, Sarmadi S, Roback DM, Fukuyama T, Baeumer W, Lascelles BDX. | Accepted, Radiation Research, January 2017
- Management of transitional cell carcinoma of the urinary bladder in dogs: important challenges to consider.Nolan MW, Gieger TL, Vaden SL. | Veterinary journal (London, England : 1997) 2015;205(2):126-7.
- Misadministration of radiation therapy in veterinary medicine: a case report and literature review.Arkans MM, Gieger TL, Nolan MW. | Vet Comp Oncol 2015.
- Interfaces with Tunable Mechanical and Radiosensitizing Properties.Berg NG, Pearce BL, Snyder PJ, et al. | ACS applied materials & interfaces 2016.
- Stereotactic radiation therapy for treatment of canine intracranial meningiomas. Griffin LR, Nolan MW, Selmic LE, et al. | Vet Comp Oncol 2014.
- Surface characterization of gallium nitride modified with peptides before and after exposure to ionizing radiation in solution.Berg NG, Nolan MW, Paskova T, et al. | Langmuir : the ACS journal of surfaces and colloids 2014;30(51):15477-85.
- Pudendal Nerve and Internal Pudendal Artery Damage May Contribute to Radiation-Induced Erectile Dysfunction.Nolan MW, Marolf AJ, Ehrhart EJ, et al. | International Journal of Radiation Oncology*Biology*Physics 2015;91(4):796-806.
- Dosimetric consequences of using contrast-enhanced computed tomographic images for intensity-modulated stereotactic body radiotherapy planning.Yoshikawa H, Roback DM, Larue SM, et al. | Vet Radiol Ultrasound 2015;56(6):687-95.
- Retrospective evaluation of interfraction ureteral movement in dogs undergoing radiation therapy to elucidate appropriate setup margins.Yoshikawa H, Nolan MW, Lewis DW, et al. | Vet Radiol Ultrasound 2015.
- Mutation spectra of Kras and Tp53 in urethral and lung neoplasms in B6C3F1 mice treated with 3,3,4,4-tetrachloroazobenzene.Bhusari S, Malarkey DE, Hong HH, Wang Y, Masinde T, Nolan M, Hooth M, Sills R, Vasconcelos D, Hoenerhoff, MJ. | Toxicologic Pathology, published online, May 2013.
- Accuracy of CT and MRI for contouring the feline optic apparatus for radiation therapy planning.Nolan MW, Randall EK, LaRue SM, Lunn KF, Stewart J, Kraft SL. | Veterinary Radiology and Ultrasound, published online, June 2013.
- Stereotactic radiation therapy for treatment of feline injection-site sarcomas: 11 cases (2008-2012).Nolan MW, Griffin LR, Custis JT, LaRue SM. | Journal of the American Veterinary Medical Association, 243:526-531, 2013.
- Intensity-modulated and image-guided radiation therapy for treatment genitourinary carcinomas in dogs.Nolan MW, Kogan L, Griffin LR, Custis JT, Biller BJ, Harmon JF, LaRue SM. | Journal of Veterinary Internal Medicine, 26(4): 987-995, 2012.
- Chemical carcinogenesis of the gastrointestinal tract (GIT) in rodents: an overview with emphasis on NTP carcinogenesis bioassays.Chandra SA, Nolan MW, Malarkey DE. | Toxicologic Pathology, 38(1): 188-197, 2010.
CVM Study Explores New Way to Treat Rare Canine Cancer
Stereotactic radiation therapy is a powerful tool in the NC State Veterinary Hospital’s arsenal, attacking cancerous tumors of the brain, spine and those that can reach the heart, all while still protecting normal tissue. Conventional radiation therapy is typically used over many weeks. SRT can often be conducted during just a handful of hospital visits.
In Search of New and Better Cancer Treatments
Can researching cancer treatment in dogs and cats have long-term impact on human cancer treatment? The answer is yes, and the proof is in the work done by Michael Nolan, associate professor, radiation oncology and biology, and others at NC State University’s College of Veterinary Medicine. Nolan is leading research in two separate areas. The first involves clinical
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