Skip to main content
NC State CVM
Think and Do The Extraordinary
GIVE to the College
Think and Do The Extraordinary
The Campaign for NC State CVM


Shelly Vaden, DVM, PhD, DACVIM

Professor, Internal Medicine

Office: 919.513.6235

Dr. Shelly Vaden graduated from the University of Georgia College of Veterinary Medicine and went on to pursue an internship at Cornell University and a residency in Small Animal Internal Medicine at North Carolina State University. She is a Diplomate of the American College of Veterinary Internal Medicine. She also has a PhD from North Carolina State University. The focus of Dr. Vaden’s scholarly activity has primarily been diseases of the kidney and lower urinary tract of dogs and cats. In recent years, this has become the primary focus of her clinical activities as well.
American College of Veterinary Internal Medicine, American Society of Veterinary Nephrology and Urology
DVM, PhD, Diplomate ACVIM
Spontaneous Animal Disease Models, Veterinary Cancer Care
Dr. Vaden is particularly interested in clinical research of the upper and lower urinary tract of the dog. This has included studies of glomerular disease, proteinuria, renal biomakers, urinary tract infection, urinary microbiome, regenerative approaches to the treatment of incontinence, and urinary carcinoma.
  • (2017) The effect of cranberry extract on the frequency of bacteriuria in dogs following acute thoracolumbar disc herniation: a randomized controlled clinical trial.Olby NJ, Vaden S, Williams K, Griffith E, Harris T, Mariani C, Munana K, Early P, Platt S, Boozer L, Giovanella C, Longshore R. | J Vet Intern Med, 2017 Jan;31(1):60-68. doi: 10.1111/jvim.14613. Epub 2016 Dec 3.
  • (2017) Clinical response and side effects associated with testosterone cypionate for urinary incontinence in male dogs.Palerme JS, Mazepa A, Hutchins R, Ziglioli V, Vaden SL. | J Am Anim Hosp Assoc, In press.
  • (2017) Evaluation of serum cytokines in cats with and without degenerative joint disease and associated pain. Veterinary Immunology and Immunopathology.Gruen ME, Messenger KM, Thomson AE, Griffith EH, Aldrich LA, Vaden S, Lascelles BD. | 2017;183:49-59.
  • (2016) A comparison of serum and plasma cytokine values using a multiplexed cytokine in cats.Gruen ME, Messenger KM, Thomson AE, Griffith EH, Paradise H, Vaden S, Lascelles BDX. | J Vet Immunol Immunopathol, 2016; 182:69-73.
  • (2016) World Small Animal Veterinary Association renal pathology initiative: classification of glomerular disease in dogsCianciolo RE, Mohr FC, Aresu L, Brown CA, James C, Jansen JH, Spangler WL, van der Lugt JJ, Kass PH, Brovida C, Cowgill LD, Heiene R, Polzin DJ, Syme H, Vaden SL, van Dongen AM, and Lees GE. | Vet Path, 2016; 53:113-135.
  • (2015) Cardiovascular-renal axis disorders in the domestic dog and cat: a veterinary consensus statement.Pouchelon JL, Atkins CE, Bussadori C, Oyama MA, Vaden SL, Bonagura JD, Chetboul V, Cowgill LD, Elliot J, Francey T, Grauer GF, Luis-Fuentes V, Moise NS, Polizin DJ, van Dongen AM, van Israel N. | J Small Anim Pract, 2015, 56:537-552.
  • (2014) Vaginal microbiota of spayed dogs with or without recurrent urinary tract infections.Hutchins RG, Vaden SL, Jacob ME, Harris TL, Bowles KD, Wood MW, Bailey CS. | J Vet Intern Med, 2014, 28:300-304.
  • (2013) The prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies.Marino CL, Lascelles BDX, Vaden SL, Gruen ME, Marks SL. | J Felin Med Surg 16(6):465-472, 2013
  • (2013) Guidelines for immunosuppressive treatment of dogs with glomerular disease absent a pathologic diagnosis.Pressler B, Vaden S, Gerber B, Langston C, Polzin D. | J Vet Intern Med 2013, 27:S55-S59.
  • (2013) Consensus recommendations for standard therapy of glomerular disease in dogsBrown S, Elliot J, Francey T, Polzin D, Vaden S. | J Vet Intern Med 2013, 27:S27-S43.
  • (2013) The Effect of an Oral Probiotic Containing Lactobacillus, Bifidobacteriaum and Bacillus species on the Vaginal Microbiota of Spayed Female Dogs.Hutchins RG, Bailey CS, Jacob ME, Harris TL, Wood MW, Saker KE, Vaden SL. | J Vet Intern Med 2013 Nov-Dec; 27(6):1368-1371. Epub 2013 Aug 28.
  • (2013) Management of bilateral idiopathic renal hematuria in a dog with silver nitrate.DiCicco MF, Fetzer T, Secoura PL, Jermyn Kieri, Hill T, Chalhoub S, Vaden S. | Can Vet J, 2013, 54:761-764.
  • (2013) Suspected carprofen toxicosis caused by coprophagia in a dog.Hutchins RG, Messenger KM, Vaden SL | J Am Vet Med Assoc. 2013:243:709-711.
  • (2013) Familial Renal Disease in Soft-Coated Wheaten Terriers. |
  • (2012) Renal disease in cats infected with feline immunodeficiency virus (FIV).Baxter KJ, Levy JK, Edinboro CJ, Vaden SL, Tompkins MB. | J Vet Intern Med, 2012, 26:238-243.
  • (2011) Assessment of urine solute and matrix effects on the performance of an enzyme-linked immunosorbent assay for measurement of interleukin-6 in dog urine.Wood MW, Nordone SK, Vaden SL, Breitschwerdt EB. | J Vet Diagn Invest, 2011, 23:316-320.
  • (2011) Renal effects of Dirofilaria immitis in experimentally- and naturally-infected cats.Atkins CE, Vaden SL, Arther RG, Ciszewski DK, Davis WL, Ensley SM, Chopade H. | J Vet Parasitol, 2011, 176:317-323.
  • (2011) Comparison of signalment, clinicopathologic findings, histologic diagnosis, and prognosis in dogs with glomerular disease with or without nephrotic syndrome.Klosterman ES, Moore GE, de Brito Galvao JF, DiBartola SP, Groman RP, Whittemore JC, Vaden SL, Harris TL, Byron JK, Dowling SR, Grant DC, Grauer GF, Pressler BM. | J Vet Intern Med, 2011, 25:206-214.
  • (2010) Outcome assessment of a computer animated model for learning about regulation of glomerular filtration rateJ Gookin, D McWhorter, S Vaden, LP Posner | Adv Physiol Educ 34: 97–105, 2010.
  • (2010) The prevalence of albuminuria in dogs and cats in an intensive care unit or recovering from anesthesia.Vaden SL, Turman CA, Harris TL, Jensen WA, Marks SL. | J Vet Emerg Crit Care, 2010, 20:479-487.
  • (2010) Prevalence of urinary tract infection in dogs after surgery for thoracolumbar intervertebral disc extrusion.Olby NJ, MacKillop E, Cerda-Gonzalez S, Moore S, Munana KR, Graffinger M, Osborne JA, Vaden SL. | J Vet Intern Med 2010, 24:1112-1117.
  • (2010) Comparison of dipstick, sulfosalicylic acid, urine protein creatinine ratio, and species-specific ELISA methodologies for detection of albumin in canine and feline urine samples.Lyon SD, Sanderson MW, Vaden SL, Lappin MR, Jensen WA, Grauer GF. | J Am Vet Med Assoc, 2010, 236(8):874-879.
  • (2010) The use of pooled versus serial urine samples to measure urine protein:creatinine ratios.LeVine DN, Zhang D, Harris T, Vaden SL. | Vet Clin Path, 2010, 39:53-56.
  • (2009) The use of computed tomography (CT) scanning and colonorectal new methylene blue infusion for the evaluation of a rectourethral fistula in an English Bulldog.Cruse AM, Vaden SL, Matthews KG, Hill TL, Robertson ID. | J Vet Intern Med, 2009, 23:931-934.
  • (2008) Evaluation of perinuclear ani-neutrophil cytoplasmic auto-antibodies as an early marker of protein-losing enteropathy and nephropathy in soft coated wheaten terriers.Allenspach K, Lomas B, Wieland B, Harris T, Pressler B, Mancho C, Lees GE, Vaden SL. | Am J Vet Res, 2008; 69:1301-1304.
  • (2008) Concurrent Hepatic Copper Toxicosis and Fanconi’s Syndrome in a Dog.Hill T, Breitschwerdt E, Cecere T, Vaden S. | J Vet Intern Med, 2008, 22:219-222.
  • (2007) Cystoscopic guided balloon dilation of a urethral stricture in a female dog.Wood MW, Vaden SL, Cerda-Gonzalez S, Keene B. | Can Vet J, 2007, 48:731-733.
  • (2006) Evaluation of Colonoscopic Allergen Provocation (COLAP) in Dogs with Proven Food Hypersensitivity Reactions.Allenspach K, Vaden S, Harris T, Gröne A, Doherr M, Griot-Wenk M, Bischoff SC, Gaschen F. | J Sm Anim Pract, 2006, 47:21-26.
  • (2005) Management and outcome of cats with ureteral calculi: 153 cases. (1984-2002).Kyles AE, Hardie EM, Wooden BG, Adin CA, Stone EA, Gregory CR, Mathews KG, Cowgill LG, Vaden S, Nyland TG, Ling GV. | J Am Vet Med Assoc 2005 Mar 15; 226(6):937-44.
  • (2005) Renal biopsy: A retrospective study of 283 dogs and 65 cats.Vaden SL, Levine J, Lees GE, Groman RP, Grauer RP, Forrester SD. | J Vet Int Med, 2005; 19:794-801.
  • (2005) Urinary tract manifestations of protothecosis in dogs.Pressler BM, Gookin JL, Sykes JE, Wolf AM, Vaden SL. | J Vet Int Med 2005; 19:115-119.
  • (2005) Clinical, clinicopathologic, radiographic, and ultrasonographic abnormalities in cats with ureteral calculi: 163 cases (1984-2002).Kyles AE, Hardie EM, Wooden BG, Adin CA, Stone EA, Gregory CR, Mathews KG, Cowgill LD, Vaden S, Nyland TG, Ling GV. | J Am Vet Med Assoc 2005; 226(6):932-936.
  • (2005) Assessment and management of proteinuria in dogs and cats: 2004 ACVIM forum consensus statement (Small Animal).Lees GE, Brown SA, Elliot J, Grauer GF, Vaden SL. | J Vet Int Med, 2005; 19:377-385.
  • (2004) The clinician investigator program in companion animal internal medicine at North Carolina State University.Bunch SE, Ford RB, Hawkins EC, Jackson MW, Vaden SL, Breitschwerdt EB. | J Vet Med Educ 2004; 31:(4):425-434.
  • (2004) In vitro prediction of canine urolith mineral composition using computed tomographic beam attenuation measurements.Pressler BM, Mohammadian LA, Li E, Vaden SL, Levine JF, Mathews KG, Robertson ID. | J Vet Rad Ultrasound, 2004; 45:189-197.
  • (2004) Dopppler ultrasonographic evaluation of gastrointestinal hemodynamics in food hypersensitivities: a canine model.Kircher P, Spaulding K, Vaden S, Lang J, Doherr M, Gaschen L. | J Vet Intern Med, 2004; 18:605-11.
  • (2004) The effects of urinary tract inflammation and sample blood contamination on urine albumin and total protein concentrations.Vaden SL, Pressler BM, Lappin MR, Jensen WA. | Vet Clin Path, 2004; 33:14-19.
  • (2003) Persistent urinary tract infections and reinfections in 100 dogs (1989-1999).Sequin A, Vaden SL, Levine J, Altier C, Stone E. | J Vet Intern Med, 2003, 17:622-631.
  • (2003) Managing renal amyloidosis in dogs and cats.Pressler BM, Vaden SL. | Vet Med 2003; 98:320-333.
  • (2003) Candida sp. urinary tract infections in 13 dogs and 7 cats: predisposing factors, treatment and outcome.Pressler BM, Vaden SL, Lane IF, Cowgill LD, Dye JA. | J Amer Anim Hosp Assoc, 2003, 39:263-270.
  • (2002) Detection of canine microalbuminuria using semi-quantitative test strips designed for use in human urine.Pressler B, Vaden SL, Jensen W, Simpson D. | Vet Clin Path 2002; 31:56-60.
  • (2002) Fecal polymerase chain reaction with 16S ribosomal RNA primers can detect the presence of gastrointestinal Helicobacter in dogs.Shinozaki JK, Sellon RK, Cantor GH, Besser TE, Mealey KL, and Vaden SL. | J Vet Intern Med 2002; 16:426-432.
  • (2000) Effects of enalapril versus placebo as a treatment for canine idiopathic glomerulonephritis.Grauer GF, Greco DS, Getzy DM, Cowgill LD, Vaden SL, Chew DJ, Polzin DJ, Barsanti JA. | J Vet Intern Med 2000; 14:526-533.
  • (2000) Food hypersensitivity reactions in soft coated wheaten terriers with protein losing enteropathy or protein-losing nephropathy or both: gastroscopic food sensitivity testing, dietary provocation and fecal immunoglobulin E.Vaden SL, Hammerberg B, Davenport DJ, Orton SM, Trogdon MM, Melgarejo LT, VanCamp SD, Williams DA. | J Vet Intern Med, 2000; 14: 60-67.
  • (2000) Familial protein-losing enteropathy and/or protein-losing nephropathy in soft-coated wheaten terriers: 222 cases (1983-1997).Littman MP, Dambach DM, Vaden SL, Giger U. | J Vet Intern Med, 2000; 14: 68-80.
  • (2000) Evaluation of intestinal permeability and gluten sensitivity in soft coated wheaten terriers with familial protein-losing enteropathy, protein-losing nephropathy, or both.Vaden SL, Sellon RK, Melgarejo LT, Williams DA, Trogdon MM, VanCamp SD, Argenzio R. | Amer J Vet Res, 2000, 61:518-524.
  • (2000) Hypercalcemia in cats: a retrospective study of 71 cases (1991-1997).Savary KCM, Price GS, Vaden SL. | J Vet Intern Med, J Vet Int Med, 2000; 14:184-189.
  • (1998) Evaluation of urine protein in dogs with pituitary-dependent hyperadrenocorticism.Hurley KJ, Vaden SL. | J Am Vet Med Assoc. 1998; 212:369-373.
  • (1998) Modulation of doxorubicin concentration by cyclosporin A in brain and testicular barrier tissues expressing p-glycoprotein in rats.Hughes CS, Vaden SL, Manaugh CA, Price GS, Hudson LC. | J Neuro-Oncology. 1998;37:45-54.
  • (1997) Pharmacokinetics of enrofloxacin in the red pacu (Colossoma brachypomum) after intramuscular, oral and bath administration.Lewbart G, Vaden S, Deen J, Manaugh C, Whitt D, Doi A, Smith T, Flammer K. | J Vet Pharmacol Ther 1997 Apr;20(2):124-8.
  • (1997) Auto IgG anti-IgE and IgG x IgE immune complex presence and effects on ELISA-based quantitation of IgE in canine atopic dermatitis, demodecic acariasis and helminthiasis.Hammerberg B, Bevier D, DeBoer DJ, Olivry T, Orton S, Gebhard D, Vaden SL. | Vet Immunology Immunopath 1997; 60:33-46.
  • (1997) Use of carbamylated hemoglobin concentration to differentiate acute from chronic renal failure in dogs.Vaden SL, Gookin J, Trogdon M, Langston CE, Levine J, Cowgill LD. | Amer J Vet Res. 1997; 58:1193-1196.
  • (1997) A retrospective case-control study of acute renal failure in 99 dogs.Vaden SL, Levine JF, Breitschwerdt EB. | J Vet Intern Med. 1997; 11:58-64.
  • (1997) Fluconazole in cats: pharmacokinetics following intravenous and oral administration and penetration into cerebrospinal fluid, aqueous humor, and pulmonary epithelial lining fluid.Vaden SL, Heit M, Hawkins EC, Manaugh C, Riviere JE. | J Vet Pharmacol Therap 1997 June; 20(3):181-186.
  • (1996) An in vitro - in vivo validation of the isolated perfused tumor and skin flap preparation as a model of cisplatin delivery to tumors.Vaden SL, Page RL, Riviere JR. | J Pharm Tox Methods 1996; 35: 173-177.
  • (1996) Vestibulovaginal stenosis in dogs: 18 cases (1987-1995).Kyles AE, Vaden SL, Hardie LM, Stone EA. | J Amer Vet Med Assoc. 1996; 209:1889-1893.
  • (1996) Management and complications following trigonal-colonic anastomosis in a dog: five-year evaluation.Smith JD, Vaden SL, Stone EA, Spaulding K, Miller RT. | J Am Anim Hosp Assoc. 1996; 32:29-35.
  • (1996) Acute tubulointerstitial nephritis with eosinophiluria in a dog.Hadrick MK, Vaden SL, Geoly FJ, Cullen JM, Douglass JP. | J Vet Int Med 1996; 10:45-47.
  • (1995) Relationship between plasma creatinine concentration and glomerular filtration rate in dogs.Finco DR, Brown SA, Vaden S L, Ferguson DC. | J Vet Pharmacol Therap 1995; 18: 418-421.
  • (1995) The effects of cyclosporine versus standard care in dogs with naturally occurring glomerulonephritis.Vaden SL, Breitschwerdt EB, Armstrong PJ, Correa MT, Brown C, Polzin DJ, Brace JJ, DiBartola SP, Barsanti JA, Crowell W, Jans H, Dimski DS, Bartges J. | J Vet Intern Med 1995; 9:259-266.
  • (1995) Pharmacokinetics of cyclosporine in woodchucks and Pekin ducks.Vaden SL, Cullen JM, Riviere JE. | J Vet Pharmacol Therap 1995, 18:30-33.
  • (1995) Splenic infarction in 16 dogs: a retrospective study.Hardie EM, Vaden SL, Spaulding K, Malarkey DE. | J Vet Intern Med 1995 May-Jun; 9(3):141-148.
  • (1995) Adrenalectomy for the treatment of hyperadrenocorticism in cats: 10 cases (1988-1992).Duesberg CA, Nelson RW, Feldman EC, Vaden SL, Scott-Moncrieff JCR. | J Am Vet Med Assoc 1995, 207:1066-1070.
  • (1994) Cerebrospinal fluid collection in rats: modification of a previous technique.Hudson LC, Hughes CS, Fletcher-Bold NO, Vaden SL. | Lab Anim Sci 1994, 44:358-361.
  • (1994) Effect of hyperthermia on cisplatin and carboplatin disposition in the isolated, perfused tumor and skin flap.Vaden SL, Page RL, Williams PL, Riviere JE. | Inter J Hyperthermia 1994, 10(4):563-572.
  • (1993) Effect of tumor presence on cisplatin and carboplatin disposition in the isolated, perfused, tumor and skin flap.Vaden SL, Williams PL, Page RL, Riviere JE. | Cancer Chemother Pharm 1993, 32:31-38.
  • (1993) Development and characterization of an isolated and perfused tumor and skin preparation for evaluation of drug disposition.Vaden SL, Page RL, Peters BP, Cline JM, Riviere JE. | Cancer Res 1993, 53(1):101-105. 0(8): 1101-1103.
  • (1992) Cobalamin deficiency associated with methylmalonic acidemia in a cat.Vaden SL, Wood PA, Ledley FD, Cornwell PE, Miller RT, Page R. | J Am Vet Med Assoc 1992, 200(8): 1101-1103.
  • (1991) Primary ciliary dyskinesia in Bichon frise littermates.Vaden SL, Breitschwerdt EB, Henrickson CK, Metcalf MR, Cohn L, Craig WA. | J Am Anim Hosp Assoc 1991, 27:633-640.
  • (1990) Pharmacokinetics, inhibition of lymphoblast transformation and subacute oral toxicity of cyclosporine in swine.Vaden SL, Riviere JE. | Am J Vet Res 1990, 50(3):399-405.
  • (1990) Comparative pharmacokinetics of doxycycline in cats and dogs.Riond JL, Vaden SL, Riviere JE. | J Vet Pharmacol Ther 1990, 13:415-424.
  • (1988) Hepatotoxicosis associated with heartworm/hookworm preventative medication in a dog.Vaden SL, Bunch SE, Duncan DE, Cullen JM. | J Am Vet Med Assoc 1988, 192(5):651-654.
  • (1985) Inotropic, chronotropic, and coronary vasodilator potency of forskolin.Vaden SL, Adams HR. | Eur J Pharmacol 1985, 118(1-2):131-137.