NC State College of Veterinary Medicine is proud to host the sixth international Veterinary Pain Short Course on pain, pain mechanisms and novel therapies in veterinary medicine, April 22 – 24, 2021 in Raleigh, NC. This meeting is unique in veterinary medicine for its emphasis upon fundamental (basic) principles and mechanisms of pain as they pertain to the veterinary patient.
Pain in the veterinary patient is a rich and complex phenomenon. The development of therapeutics to manage that pain state has been a subject of great interest, and advances in therapeutics reflects upon the growth in our understanding of the basic mechanisms in pain processing.
Interest in pain and its management is a natural focus of the veterinary profession as mandated by the AVMA and the standards set by the AAHA/AAFP and practiced by the International Veterinary Association for Pain Management (IVAPM).
Vet Pain is unique for a detailed emphasis upon fundamental principles and mechanisms of pain as they pertain to the veterinary patient.
Course consists of ~20 lectures with comprehensive lecture handouts and representative papers
This course was designed for veterinarians and animal researchers interested in the study of pain in animals and humans and for pharmaceutical researchers and companies interested in the development of veterinary analgesics.
|8:00 - 8:30am||Introductory remarks||Duncan Lascelles|
|8:30 - 9:00am||Pain management as challenge in veterinary medicine (incidence/opiate restrictions, etc)||William Muir|
|9:00 - 10:00am||Over view of recent advances in basic understanding of pain signaling||Tony Yaksh|
|10:00 - 10:30am||Break|
|10:30 - 11:30am||Over view of recent advances in basic understanding of pain signaling||Tony Yaksh|
|11:30am - 12:30pm||Lunch|
|Neuroinflammation in Pain Processing: Mechanisms|
|12:30 - 1:30pm||Basic role of Innate and adaptive immunity in the RA phenotype||Camilla Svensson|
|1:30 - 2:30pm||Immune signaling in visceral hypersensitivity|
|2:30 - 3:00pm||Break|
|3:00 - 4:00pm||Immune cells (Macrophages and Lymphocytes) in nociceptive processing||Robert Sorge|
|4:00 - 5:00pm||CSF & Plasma Markers of Neuroinflammation|
|Therapeutic interventions that target inflammatory signaling|
|8:00 - 8:15am||Introduction –Anti-neuroinflammatory theme||Tony Yaksh|
|8:15 - 9:00am||Synovetin Science of this therapeutic approach||Steve Fox|
|9:00 - 9:45am||Neuraxial IL10 and therapeutic approaches||Andreas Beutler|
|9:45 - 10:30am||NGF and inflammatory signaling||Duncan Lascelles|
|10:30 - 11:00am||Break|
|11:00 - 11:45am||Mesenchymal Cells||Kyla Ortved|
|11:45am - 12:30pm||NSAIDs||Kristen Messenger|
|12:30 - 1:15pm||Lunch|
|1:15 - 2:00pm||Soluble epoxide hydrolase inhibitors||Alonso Guedes|
|2:00 - 3:00pm||Capsaicin and Resinferatoxin: IT and IA||Mike Iaderola|
|3:00 - 3:15pm||Break|
|3:15 - 4:30pm||Resolvins and Protectins||Charles Serhan|
|4:30 - 5:30pm||Free time|
|5:30 - 8:00pm||Reception at NC State CVM. Tours of facilities|
|Veterinary Pain Medicine in the era of restricted opiate availability|
|8:00 - 8:30am||Introduction: the history and impact||Bill Muir|
|8:30 - 9:30am||Novel pharmacologic methods to produce extended regional blocks: current science||Daniel Kohane|
|9:30 - 10:00am||Break|
|10:00 - 11:00am||Liposome encapsulated bupivacaine: The human experience||Jeffrey Gadsden|
|11:00am - 112:00pm||Liposome encapsulated bupivacaine – an evidence based and practical discussion||Dottie Brown|
|12:00 - 12:15pm||Wrap up|
|NC Vet Pain 2020 Speakers|
|Andreas Beutler M.D., PhD
CEO, Interventional AnalgesiX Inc.
|Dr. Beutler is the Founder and CEO of Interventional AnalgesiX Inc. (IAX), a preclinical-stage biotech startup company developing non-addictive analgesics for hitherto intractable chronic pain. Dr. Beutler has authored >50 scientific publications (including in PNAS, JCI, Ann. Neurol., Nature Genetics). As a Principal Investigator, he has been continuously supported by research grants from the National Institutes of Health (NIH) from 2003 to the present, with currently active funding (as of 2019) by an SBIR grant (2019-2020) and an R01 grant (2017-2022) from the National Institutes of Neurological Disorders and Stroke (NINDS).|
|Dottie Brown MS, DVM, DACVS
Elanco Animal Health
|Dr. Brown received a B.S. in Zoology from the University of Maryland and her DVM from the Virginia-Maryland Regional College of Veterinary Medicine. She completed her internship and surgical residency at the University of Pennsylvania, School of Veterinary Medicine and received a Maters in Clinical Epidemiology from the University of Pennsylvania, School of Medicine. Dr. Brown has worked at Elanco Animal Health for two years and is currently the Director of Companion Animal Research and lead executional scientist for Translational Comparative Medical Research. She started her career at the University the University of Pennsylvania, where she was a Professor of Surgery, had a sponsored translational research program focusing on the measurement and management of chronic pain in companion animals, and was Executive Director of the Veterinary Clinical Investigations Center. Her focus at Elanco is on the discovery, development and registration of new drugs for animal health; and the design and implementation of translational studies with the goal of improving both human and animal health.|
|Steve Fox MS, DVM, MBA, PhD
Senior Veterinarian, Exubrion Therapeutics
|Steve is an integral member of the Exubrion team. His wealth of experience in veterinary medicine includes over 30 years as a practicing orthopedic surgeon and pain management specialist. He also served as President of the Veterinary Orthopedic Society (VOS) and Securos Surgical. He has many years of experience in analgesic research and development, teaching, and public speaking. He holds a BS in mechanical engineering from the US Naval Academy and an MS in nutritional biochemistry and a DVM from the University of Illinois. He completed his internship at Rowley Memorial Hospital and surgical residency at the University of Florida. In addition, he holds an MBA and a PhD in pain management; both from Massey University in New Zealand.|
|Jeffrey Gadsden MD, FRCPC, FANZCA
Associate Professor, Duke University School of Medicine
Chief, Division of Orthopaedic, Plastic and Regional Anesthesiology
Regional Anesthesiology and Acute Pain Medicine Fellowship Director
Duke University Medical Center
|Dr. Gadsden is an associate professor of anesthesiology and chief of Duke Anesthesiology’s Division of Orthopaedics, Plastics and Regional Anesthesiology. He’s also the associate director of the department’s Regional Anesthesiology and Acute Pain Medicine Fellowship.|
|Alonso Guedes DVM, MS, PhD, Dipl. ACVA
Associate Professor of Anesthesia, University of Minnesota, College of Veterinary Medicine
|Dr. Alonso Guedes is a DVM, PhD and board certified veterinary anesthesiologist interested in understanding how calcium and lipid signaling are involved in chronic disease biology. Diseases of interest include osteoarthritis, laminitis and asthma.His laboratory is invested in the discovery of novel and actionable targets for the treatment of chronic painful conditions such as osteoarthritis, laminitis and asthma, using basic and translational models. Current work focuses on two target proteins, CD38 (calcium signaling) and sEH (lipid metabolism).|
|Mike Iadarola PhD
Senior Research Scientist
Department of Perioperative Medicine
National Institutes of Health
|"Dr. Michael J. Iadarola graduated from American University and obtained a Ph.D. in pharmacology from Georgetown University. Postdoctoral studies in neuroscience followed at Duke University.
Dr. Iadarola investigates the molecular and physiological mechanisms of pain transmission and control. His investigations focus on translational approaches to new pain treatments and on the fundamental molecular biology of pain sensing neurons and their response to acute and persistent pain"
|Chris Klein M.D.
Consultant, Department of Neurology, Mayo Clinic
|Dr. Klein received his Bachelor of Science degree in Molecular Genetics, and a Masters of Science in Pathology-Neurogenetics from Ohio State University. Dr. Klein went on to receive his Medical Doctorate from the Medical College of Ohio in 1995. Dr. Klein currently works as a Consultant in the Department of Neurology, Department of Medical Genetics, and the Division of Clinical Biochemistry & Immunology at the Mayo Clinic in Rochester, Minnesota. Dr. Klein is the leading researcher of HSAN1E in the United States. He has published several academic papers in his field including “Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss,” Which is one of the first comprehensive papers discussing HSAN1E and some of the known affected families. Dr. Klein and his team of researchers at Mayo Clinic are currently working on discovering the causal connection between the DNMT1 mutation and HSAN1E. Dr. Klein hopes that this research will one day lead to discovery of therapies and more.|
|Duncan Lascelles BSc, BVSc, PhD, FRCVS, CertVA, DSAS(ST), DECVS, DACVS
Professor of Translational Pain Research and Management.NC State College of Veterinary Medicine
|Dr Lascelles is director of the Comparative Pain Research and Education Centre (CPREC). His research program (Translational Research in Pain [TRiP]) is dedicated to answering critical questions about pain control and pain mechanisms through high quality, innovative research. His career has been focused on developing algometry methods (methods to measure pain) in spontaneous disease animal models (pets with naturally occurring disease), and probing tissues from well-phenotyped animals with spontaneous disease to understand the neurobiology, with a strong translational focus. The aim of his research is to improve pain control in companion animals, and facilitate analgesic development in human medicine. He has authored over 180 peer reviewed research papers and reviews and 190 research abstracts, as well as over 30 book chapters.|
|Patrick Mantyh PhD, JD
Professor of Pharmacology, University of Arizona
|Dr. Mantyh is a Professor of Pharmacology at the University of Arizona. He received his PhD in neuroscience from the University of California, San Francisco in 1981 and completed a postdoctoral fellowship in pharmacology at the University of Cambridge in 1983. Dr. Mantyh's lab first developed a model of bone cancer pain in 1999 and then a model of bone fracture pain in 2007. These models are now used by labs around the world. More recently, his focus has been to investigate the mechanisms that drive musculoskeletal pain and bone remodeling, and to use these findings in the development of novel therapies that reduce pain and promote skeletal health.|
|Kristen Messenger DVM, PhD, DACVAA, DACVCP
Assistant Professor of Pharmacology at North Carolina State University, College of Veterinary Medicine
|Kristen Messenger is an Assistant Professor of Pharmacology at North Carolina State University. She is board-certified in both anesthesia and clinical pharmacology and currently works with each of these specialty services at NCSU. Dr. Messenger’s research interests are in the pharmacokinetics and pharmacodynamics of analgesic and anesthetic drugs, with a special focus on NSAIDS and opioids in companion animals.|
|William Muir DVM, PhD, DACVAA, DACVECC
Q Test Labs"
|Dr. Muir served as Professor and Director of Anesthesiology and Pain Management at The Ohio State University College of Veterinary Medicine (1970-2007), as the research director for the US based Research Medications and Testing Consortium (RMTC) for 2 years (2007-2009), and as the Chief Medical Officer for the Animal Medical Center in New York City (2009-2012). He currently is a Professor of physiology in the College of Veterinary Medicine at Lincoln Memorial University in Harrogate TN, and Scientific Advisor for QTest laboratories (preclinical research facility) in Columbus OH.|
|Kyla Ortved DVM, PhD, DACVS, DACVSMR
Jacques Jenny Endowed Term Chair of Orthopedic Surgery
New Bolton Center
University of Pennsylvania
|Kyla is an assistant professor of Large Animal Surgery at New Bolton Center, the large animal campus of the University of Pennsylvania School of Veterinary Medicine, located in Kennett Square, Pennsylvania. She received her DVM degree from the University of Guelph in 2006 and completed her large animal surgical residency at Cornell University in 2010. Following her residency, Dr. Ortved went on to obtain a PhD in equine cartilage repair at Cornell University in June 2014. She has a long-standing interest in the development, prevention and treatment of post-traumatic osteoarthritis and is excited by the translational nature of this research between veterinary and human medicine.|
|Charles Serhan PhD, DSc
Simon Gelman Professor of Anaesthesia (Biochemistry and Molecular Pharmacology) at Harvard Medical School and Professor of Oral Medicine, Infection and Immunity at Harvard School of Dental Medicine.
|Prof. Charles Nicholas Serhan is the Simon Gelman Professor of Anaesthesia (Biochemistry and Molecular Pharmacology) at Harvard Medical School and Professor of Oral Medicine, Infection and Immunity at Harvard School of Dental Medicine. He is Director of the Center for Experimental Therapeutics and Reperfusion Injury at Brigham and Women’s Hospital. In 1987, he joined the faculty at Harvard Medical School in 1987 and received an honorary degree from Harvard University (1996). He has received several awards including an NIH MERIT award (2000) and has delivered > 50 keynote and plenary lectures. Among these, 2008 William Harvey Outstanding Scientist Medal and AAAS Fellow in 2011. In 2010, he received the Society for Leukocyte Biology Bonazinga Award for outstanding research on leukocytes, The American College of Rheumatology Hench (Nobel Laureate) Award Lecture in 2011 and is a Mérieux 2013 Laureate. In 2016, he received the IUBMB Lecture Metal and the Ross Prize in Molecular Medicine. In 2017, he received the International Eicosanoid Research Foundation’s Lifetime Achievement Award and the American Society of Investigative Pathology (ASIP) 2018 Rous Whipple Award.
Serhan laboratory focuses on structural elucidation of novel bioactive molecules that activate the resolution of inflammation. Our overall mission is “To identify novel mediators, pathways, and their cellular receptors and targets critical in promoting resolution of inflammation and reperfusion tissue injury and establish their relation to human disease.” Our ongoing studies focus on structural elucidation of novel molecules and pathways that are pro-resolving and endogenous anti-inflammatory chemical signals.
|Robert Sorge BSCc, MA, PhD
Department of Psychology
University of Alabama at Birmingham
|Dr. Sorge is primarily interested in the ways in which the immune system modulates pain and ways that we can utilize the immune system to reduce pain. His work has uncovered a sex difference in the immune cell involvement in maintenance of chronic pain in rodents. Currently, his lab is focused on the ways in which diets alter immune system activity and the subsequent effects on pain and recovery from injury. His lab has developed both a model Standard American Diet and an Anti-Inflammatory diet to be used as an intervention for chronic pain. Additionally, Dr. Sorge has translated his preclinical work to clinical patients wherein prescribed diets can reduce pain. Dr. Sorge is a Rita Allen Foundation Scholar and has received funding for his work through the American Pain Society, International Association for the Study of Pain and the Rita Allen Foundation. Dr. Sorge earned his bachelor’s degree at McMaster University, his Master’s at Wilfrid Laurier University and his PhD at Concordia University. After two postdoctoral fellowships at McGill University, he joined the Department of Psychology at the University of Alabama at Birmingham in 2012 as an Assistant Professor.|
|Camilla Svensson MS, PhD
Department of Physiology and Pharmacology
Karolinska Institutet, Stockholm, Sweden
|Professor Svensson obtained her PhD at UC San Diego, where she also held a postdoctoral research position at the Department of Medicine. She subsequently moved on to Karolinska Institute, Stockholm, Sweden, where she today holds a position as Associate Professor and research group leader for Molecular Pain research at the Department of Physiology and Pharmacology. Her research is focused on investigating the role of neuroinflammation in the peripheral and central nervous system, with particular focus on pain mechanisms in conditions with joint inflammation and autoimmunity, such as rheumatoid arthritis.|
|Tony Yaksh, PhD
Distinguished Professor of Anesthesiology and Pharmacology
University of California, San Diego
La Jolla, CA
|Dr. Yaksh joined UCSD in 1988 as Professor and Vice Chairman for Research in the Department of Anesthesiology and Professor of Pharmacology. Dr. Yaksh's research interests are primarily in the area of the biology of pain processing, with a particular interest in the role of non-neuronal cells and lipid mediators in pain transmission. He is an expert on issues related to spinal drug kinetics and the evaluation of the safety of spinally delivered agents. He has published more than 800 papers with 46,000 citations in >26,000 papers and edited 6 texts and is working on a 7th. He has been a mentor to more than 150 post-graduate Fellows. He has been funded consistently by the NIH since 1977 and has twice been a Jacob Javitz award recipient. He is currently the Principal Investigator on several NIH grants and numerous contracts. He has received honors and awards, including the FWL Kerr award of the American Pain Society, the American Society of Anesthesiology (ASA) Award for Excellence in Research, the Rovenstein award from the New York Society of Anesthesiology, and the Torsten Gordh award from the Swedish Society of Medicine.|
DVM & PI Registration: Before January 31st – $400. After January 31st – $495
Trainee Registration: Before January 31st – $125. After January 31st – $225
Room rate for the course is $189 per night + taxes.
Included in the room rate :
- Free airport shuttle
- Free made-to-order breakfast
- Free WiFi in your suite and around the hotel
- Complimentary evening reception
- Fitness Center
Thank you to our Sponsors