NC Veterinary Pain Short Course
APRIL 20 @ 8:00 AM - APRIL 22 @ 1:00 PM
hosted by CPREC (NC State Comparative Pain Research and Education Center)
NC State College of Veterinary Medicine is proud to host the sixth international Veterinary Pain Short Course on pain, pain mechanisms and novel therapies in veterinary medicine, APRIL 20, 21 AND 22: Embassy Suites Raleigh – Durham Airport/Brier Creek, Raleigh NC. This meeting is unique in veterinary medicine for its emphasis upon fundamental (basic) principles and mechanisms of pain as they pertain to the veterinary patient.
Pain in the veterinary patient is a rich and complex phenomenon. The development of therapeutics to manage that pain state has been a subject of great interest, and advances in therapeutics reflects upon the growth in our understanding of the basic mechanisms in pain processing.
Interest in pain and its management is a natural focus of the veterinary profession as mandated by the AVMA and the standards set by the AAHA/AAFP and practiced by the International Veterinary Association for Pain Management (IVAPM).
Vet Pain is unique for a detailed emphasis upon fundamental principles and mechanisms of pain as they pertain to the veterinary patient.
Course consists of lectures with comprehensive lecture handouts and representative papers
This program has applied for 16.5 hours of veterinary continuing education credit in jurisdictions that recognize RACE approval.
Schedule Thursday April 20
|8:30am – 12:00pm||Update on pain mechanisms||Tony Yaksh|
|12:00 – 1:00pm||Lunch|
|Mechanisms of head and neck pain|
|1:00 – 1:30pm||Comparative neuroanatomy of head sensory system||TBD|
|1:30 – 2:15pm||Comparative biology of TG vs. DRG||Josh Emrick|
|2:15 – 3:15pm||Neurobiology of H&N radiation associated pain||Mike Nolan|
|3:15 – 3:30pm||Break|
|3:30 – 4:30pm||Neurobiology of TMJ pain in humans||Andrea Nackley|
|4:30 – 5:30pm||Assessment of ‘head pain’ – challenges and solutions||Paulo Steagall|
Schedule Friday April 21
|Evolutionary clues to pain mechanisms; Genetics of pain|
|8:30 – 9:30am||Role of innate and adaptive immunity in RA and OA||Lynne Sneddon|
|9:30 – 10:30am||Evolutionary clues about functions and mechanisms related to pain: mollusks and Arthropods||Edgar Walters|
|10:30 – 11:00||Break|
|11:00 – 12:00pm||What can the naked mole rat teach us about pain mechanisms?||Thom Park|
|12:00 – 1:00pm||Lunch|
|1:00 – 2:00pm||Insight from the grasshopper mouse||Ashlee Rowe|
|2:00 -3:00pm||Understanding genetics of pain using Drosophilia||Dan Tracey|
|3:00 – 3:30pm||Break|
|3:30 – 4:30pm||Human Pain Genetics||Luda Diatchenko|
|5:00 – 6:30pm||Reception / Poster Session|
Agenda Saturday April 22
|Science of new targets for chronic pain|
|8:30 – 9:15am||Science of laser therapy||Juanita Anders|
|9:15 – 10:00am||Science of targeting NGF as an analgesic strategy||Anne-Marie Malfait|
|10:00 – 10:45am||Evidence and science of ketamine for chronic pain control||Bea Monterio|
|10:45 – 11:30am||Science of cannabindiol/CBD as an analgesic||TBD|
|Juanita Anders M.S., PhD
Professor of Anatomy, Physiology and Genetics. USU School of Medicine
Dr. Anders is is a Professor of Anatomy, Physiology and Genetics and Professor of Neuroscience, at Uniformed Services University of the Health Sciences. Professor Anders is an internationally recognized expert in Photobiomodulation (PBM) research and has served as invited Chair and speaker globally. Her specialty is nervous system injury and repair mechanisms, pain modulation using PBM and light/tissue interactions. Dr. Anders received her Ph.D. in Anatomy from the University of Maryland Medical School then joined the National Institutes of Health in the Laboratory of Neuropathology and Neuroanatomical Sciences, NINDS. Currently she is funded by the US Department of Defense and NIH to investigate the use PBM Therapy as a non-invasive, non-pharmaceutical alternative for the management of neuropathic pain.
Professor Anders has served and continues to serve as a member of numerous state, national, and international scientific review panels including the National Institutes of Health, the Food and Drug Administration, Veterans Affairs, the Department of Defense, and the Congressionally Directed Medical Research Programs. She also serves on the Executive Councils and Scientific Advisory Boards of numerous international laser conferences. She is the past president of the North American Association of Laser Therapy, a founding member of the International Academy of Laser Medicine and Surgery, Past President of the American Society of Lasers in Medicine and Surgery and Past Co-Director of the Optical Society of America (OPTICA) Photobiomodulation Technical Group. She currently serves on the Advisory Board of the Optica Photobiomodulation Technical Group. She is a Senior Editor of Photobiomodulation, Photomedicine and Laser Surgery, Associate Editor of Lasers in Medical Science, and Frontiers in Neuroscience (Neurogenesis) and on the editorial board of Physiotherapy Practice and Research and Laser Therapy.
|Luda Diatchenko, MD, PhD
Professor, Pfizer Canada Professor in Pain Research. McGill University
Luda Diatchenko, MD, PhD is a Canada Research Chair in Human Pain Genetics and a Professor at the Faculty of Dentistry and Medicine, at McGill University. Dr. Diatchenko earned her MD and PhD in the field of Molecular Biology from the Russian State Medical University. Dr. Diatchenko started her career in industry, she was a Leader of the RNA Expression Group at Clontech, Inc., and subsequently, Director of Gene Discovery at Attagene, Inc. During this time, Dr. Diatchenko was actively involved in the development of several widely-used and widely-cited molecular tools for the analysis of gene expression and regulation. Dr. Diatchenko’s academic career started in 2000 in the Center for Neurosensory Disorders at the University of North Carolina. Her research since then is focused on determining the genetic mechanisms that impact and shape human pain perception and risk of development of chronic pain conditions, enabling new approaches to identify drug targets, treatment responses to analgesics, and diagnostics. In total, Dr. Diatchenko has authored or co-authored over 150 peer-reviewed research papers in journals, 10 book chapters, and edited a book in human pain genetics. She is a past and current member and an active officer of several national and international scientific societies, including the International Association for the Study of Pain, the American Pain Society, and Canadian Pain Society.
|Duncan Lascelles BSc, BVSc, PhD, FRCVS, CertVA, DSAS(ST), DECVS, DACVS
Professor of Translational Pain Research and Management.
Dr. J. McNeely and Lynne K. DuBose Distinguished Professorship in Musculoskeletal Health
NC State College of Veterinary Medicine
Dr Lascelles is director of the Comparative Pain Research and Education Centre (CPREC). His research program (Translational Research in Pain [TRiP]) is dedicated to answering critical questions about pain control and pain mechanisms through high quality, innovative research. His career has been focused on developing algometry methods (methods to measure pain) in spontaneous disease animal models (pets with naturally occurring disease), and probing tissues from well-phenotyped animals with spontaneous disease to understand the neurobiology, with a strong translational focus. The aim of his research is to improve pain control in companion animals, and facilitate analgesic development in human medicine. He has authored over 180 peer reviewed research papers and reviews and 190 research abstracts, as well as over 30 book chapters
|Anne-Marie Malfait, M.D., Ph.D.
The George W. Stuppy, MD, Chair of Arthritis
Professor, Department of Internal Medicine, Division of Rheumatology, Rush Medical College
Pain in osteoarthritis is the focus of Dr. Malfait’s research group at Rush University. She has 24 years of expertise with animal models of rheumatoid arthritis and osteoarthritis. During an 8-year tenure as Senior Principal Investigator at Pfizer, Dr Malfait was project leader in the Research Team for development of disease-modifying osteoarthritis drugs (DMOADs). In this capacity, she was directly involved with all aspects of the DMOAD discovery process, including target identification, compound development, proof-of-concept studies, animal modeling, safety assessments, biomarker development and design of phase I clinical trials. Rush provides a unique environment for the study of musculoskeletal diseases and allows Dr Malfait to integrate her early research training (which focused on the areas of cartilage biology and proteases, animal models of arthritis and cytokine regulation), prior exposure to clinical rheumatology, and pharmaceutical experience, in order to establish a laboratory for translational osteoarthritis research.
|Kristen Messenger DVM, PhD, DACVAA, DACVCP
Assistant Professor of Pharmacology at North Carolina State University, College of Veterinary Medicine
Kristen Messenger is an Assistant Professor of Pharmacology at North Carolina State University. She is board-certified in both anesthesia and clinical pharmacology and currently works with each of these specialty services at NCSU. Dr. Messenger’s research interests are in the pharmacokinetics and pharmacodynamics of analgesic and anesthetic drugs, with a special focus on NSAIDS and opioids in companion animals.
|Bea Monteiro PhD, PgDip, ISFM AdvCert FB
Université de Montréal | UdeM · Department of Clinical Sciences
Resident at the American College of Animal Welfare
Dr. Beatriz Monteiro is a veterinarian and researcher passionate about improving pain management and promoting animal welfare. After graduating from Sao Paulo State University (Unesp-Botucatu), Brazil, she moved to Canada where she did two internships at the University of Guelph and a PhD at the University of Montreal. Recently, she completed an Advanced Certificate in Feline Behaviour by the International Society of Feline Medicine (ISFM), and a Postgraduate Diploma in International Animal Welfare, Ethics and Law (IAWEL) by the University of Edinburgh.
Dr. Monteiro works at the University of Montreal while also enrolled in a residency program of the American College of Animal Welfare. She has authored nearly 60 peer-reviewed publications and lectured in numerous conferences. Dr. Monteiro is the chair of the World Small Animal Veterinary Association - Global Pain Council (WSAVA - GPC) and is part of the editorial board of the Journal of Feline Medicine and Surgery (JFMS).
|William Muir DVM, PhD, DACVAA, DACVECC
Q Test Labs
Dr. Muir served as Professor and Director of Anesthesiology and Pain Management at The Ohio State University College of Veterinary Medicine (1970-2007), as the research director for the US based Research Medications and Testing Consortium (RMTC) for 2 years (2007-2009), and as the Chief Medical Officer for the Animal Medical Center in New York City (2009-2012). He currently is a Professor of physiology in the College of Veterinary Medicine at Lincoln Memorial University in Harrogate TN, and Scientific Advisor for QTest laboratories (preclinical research facility) in Columbus OH.
|Andrea G. Nackley, PhD
Associate Professor in Anesthesiology
Director, The Translational Pain Research Laboratory
Faculty, Center for Translational Pain Medicine
Duke University, Department of Anesthesiology
Center for Translational Pain Medicine
Dr. Andrea Nackley is an Associate Professor in the Department of Anesthesiology’s Center for Translational Pain Medicine (CTPM) at Duke University School of Medicine. She is Director of the Translational Pain Research Laboratory, where her program marries pain neurobiology, behavioral pharmacology, and molecular genetics in mouse and man to better understand what causes chronic pain and how to effectively treat it. During the past 19 years, her expertise in this area has been applied to the study of how alterations in gene regulation, protein expression, and receptor signaling contribute to chronic ‘primary’ overlapping pain conditions. Key discoveries include: 1) determining human gene polymorphisms associated with experimental and clinical pain, 2) elucidating the molecular mechanism whereby pain-relevant polymorphisms lead to functional changes in protein expression and activity, and 3) and identifying biomarkers that distinguish individuals with localized versus overlapping chronic pain conditions. Further, her lab was the first to demonstrate a critical role for peripheral adrenergic receptor beta-3 in the development of chronic pain and neuroinflammation, which remains a primary research focus. Dr. Nackley is an active leader in the field, participating in pain-relevant workshops and delivering invited lectures around the globe. She is an Associate Editor for Frontiers in Pain Research and serves on the Board of Directors for the United States Association for the Study of Pain (USASP). In recognition of her scholarly activity in the Pain field, she received the John C. Liebeskind Career Scholar Award from the American Pain Society
|Michael W. Nolan, DVM, PhD, Diplomate ACVR (Radiation Oncology)
Professor, Radiation Oncology and Biology
NC State College of Veterinary Medicine
The fundamental aim of Dr. Nolan's research is to reduce discomfort and side effects in patients undergoing cancer treatment. In particular, the Nolan lab studies the complex molecular signaling pathways that are activated in patients experiencing radiotherapy-associated pain, and they are working hard to understand how pain signaling can influence tumor behavior. Such knowledge is critical to developing new therapies that will maximize both quality and quantity of life in pets and people with cancer.
Dr. Nolan graduated from State University of New York at Stony Brook, earned his DVM degree at Virginia-Maryland Regional College of Veterinary Medicine, and his PhD in Radiation and Cancer Biology from Colorado State University. He completed an internship at NYC Veterinary Specialists and a residency in radiation oncology at Colorado State University. He is a Diplomate of the American College of Veterinary Radiology (sub-specialty of Radiation Oncology). Clinically, Dr. Nolan has a special interest in emerging technologies and techniques in radiation oncology. His research is focused on normal tissue injury secondary to radiation therapy, and developing novel therapeutic strategies to maximize comfort in patients with cancer
|Thomas Park, PhD
Professor and Associate Department Head
University of Illinois
Our research focuses on the neurobiology of sensory information processing, using two model systems: sound localization in echolocating bats, and orientation to touch in naturally blind naked mole-rats. We combine behavioral and physiological techniques to study these highly adapted systems, and to examine fundamental questions about sensory organization and behavior.
In many cases, progress in understanding sensory behavior and neural processing has been aided by the analysis of model systems. Echolocating bats are considered to be hearing specialists. They rely on hearing the echoes from their own calls to navigate though their environment, and to identify and localize the flying insects that they prey upon. In my lab, we study the behavior and neural information processing associated with sound localization.
In contrast to bats, the naked mole-rat, a totally subterranean animal, does not localize sounds well, nor is it able to use visual information. Rather, these animals place a great emphasis on touch for gathering and processing spatial information. Our focus with the naked mole-rats is on their “body whiskers,” a unique array of sensory hairs that criss-crosses their otherwise furless bodies, and functions in guiding orientation behaviors.
|Ashlee H. Rowe PhD
Assistant Professor of Biology
University of Oklahoma
The Rowe lab addresses this question by investigating the molecular and physiological mechanisms underlying sensory adaptations that mediate predatory behavior. We study predator-prey interactions because they rely on fast, specialized sensory inputs and neuromuscular responses, and we focus on ion channels in nerve and muscle tissue because they encode sensory information and regulate responses to external stimuli. Interactions between carnivorous grasshopper mice (a.k.a., scorpion mice) and their chemically-defended prey (scorpions, darkling beetles, centipedes, tarantulas) provide a powerful, ecologically relevant model for examining the role of ion channels in sensory adaptations that mediate predatory behavior.
In 2017, I was recruited by the University of Oklahoma to fill a Molecular Neurobiology position as part of a cluster hire in The Biology of Behavior. This transition enabled me to advance my research on the biophysical interactions between venom peptides and their ion channel targets via collaborations with researchers in the NIH-funded Oklahoma Center of Biomedical Research Excellence (COBRE) in Structural Biology. I am currently working with proteomics and structural biology researchers to elucidate the mechanisms of peptide-mediated ion channel inhibition. A better understanding of the biophysical interactions between venom peptides and Nav1.8 will provide a structural guide for developing novel pain therapeutics.
|Lynne Sneddon PhD
University of Gothenburg
Using an integrative approach my research seeks to understand the mechanisms underpinning animal behaviour by employing techniques in genomics, molecular biology, physiology and neurobiology. In 2002 I was the first to characterise nociceptors that detect painful stimuli on the head of a fish and have since investigated the capacity for pain, fear and stress to drive improvements in the welfare of fishes and other aquatic animals. My research also explores how intraspecific variation or animal personality influences the response to environmental variation such as pH, temperature and hypoxia which are relevant to understanding the impact of climate change.
|Paulo Steagall DVM, PhD, MSc, Dipl. DACVAA
l'Université de Montréal
Paulo V. Steagall, DVM, MS, PhD, DACVAA, is an associate professor of veterinary anesthesiology and analgesia at University of Montreal in Montreal, Canada. He earned his DVM and completed an anesthesiology residency at São Paulo State University in Brazil, where he also earned his master’s degree and PhD with an emphasis in feline analgesia. Dr. Steagall is a member of the Journal of Feline Medicine and Surgery editorial board, the WSAVA Global Pain Council, and the WSAVA Dental Guidelines Committee. He is also the cochair of the WSAVA Therapeutic Guidelines group. Dr. Steagall has published more than 80 articles on pain management in small animals and coedited the book Feline Anesthesia and Pain Management
|W. Dan Tracey PhD
Linda and Jack Gill Chair of Neuroscience
Research in the Tracey laboratory aims to understand the general principles that govern the specification and function of neuronal circuits. We study this problem using the fruitfly Drosophila melanogaster whose relatively simplified nervous system must perform many of the same computations that are carried out by our own. Despite its simplified brain, Drosophila perform an array of complex behaviors. Powerful genetic tools of Drosophila enable the dissection of neural circuits with a precision that is not matched in any other model system. Genetically encoded calcium sensors allow us to measure the neuronal activity of identified neurons while neuronal silencers and activators allow us to determine the behavioral consequences of the same activity. Optogenetic tools allow us to activate behaviors via remote control by simply shining light on the animals. Our primary focus is to use the fly model to identify circuits and genes that function in nociception. These studies lead to a greater understanding pain signaling. In addition, we are attempting to identify the molecules that are used in neurosensory mechanotransduction, which underlies our sense of touch. Finally, we are attempting to build trans-synaptic tracers for use in Drosophila. These tools will enable visualization of interconnected circuits in the brain of flies and may eventually be extended to studies in mammals.
|Edgar T. Walters, PhD.
UTHealth Houston, McGovern Medical School
The often permanent pain caused by spinal cord injury (SCI) is one of the most intractable forms of chronic pain known. We have found that behavioral hypersensitivity in rats tested months after SCI is closely correlated with a dramatic, widespread increase in the incidence of spontaneous activity (SA) in the cell bodies of nociceptors, with this SA being expressed both in vivo and for at least a day after dissociating and culturing nociceptors. Current projects employ multidisciplinary methods (behavioral tests, whole cell patch clamp, immunocytochemistry, biochemistry, molecular biology) to define electrophysiological mechanisms of SCI-induced SA, cell signaling alterations underlying the development and maintenance of chronic SA, and behavioral consequences of nociceptor SA.
Comparative insights into nociceptor memory functions and mechanisms. Our work and others’ have revealed striking similarities in how the nociceptors of invertebrates and vertebrates detect and "remember" injury-related stimulation. Mollusks have well-known advantages for relating the properties of identifiable cells to behavioral functions. We use the large marine snail, Aplysia, to define cellular signaling pathways important for the induction and long-term maintenance of hyperexcitability in the cell body, axon, and peripheral and central terminals of identified nociceptors. Some of these signals also contribute to long-term alterations in vertebrate nociceptors, including the cAMP-PKA-CREB and NO-cGMP-PKG pathways. Others have not yet been investigated in vertebrates, such as a potent pathway that depends upon local depolarization (and protein synthesis) but not calcium signals. We found recently that another mollusc, the longfin Atlantic squid, displays long-term nociceptive sensitization of defensive behavior paralleled by sensitization of the peripheral branches of nociceptors. Comparisons of behavioral alterations and nociceptor memory in squid, Aplysia, and rats point to shared functions that have shaped the evolution of nociceptor plasticity and to conserved mechanisms that may be fundamental to many memory-like phenomena, including some forms of chronic pain.
|Tony L. Yaksh, Ph.D.
Distinguished Professor of Anesthesiology and Pharmacology
University of California, San Diego
Tony L. Yaksh obtained his Ph.D. degree from Purdue University (1971). He served in the U.S. Army (Captain / Cmlc) in the Biomedical Laboratory at Edgewood Arsenal, MD (1971-73), was a research scientist in the School of Pharmacy, University of Wisconsin (1973-76) and an Associate Research Scientist in Anatomy at University College London with Pat Wall (1976-77). He worked at the Mayo Clinic with Dr. Frederick Kerr in Rochester, MN in Pharmacology and Neurosurgery (1977-1988), where he rose to the rank of Consultant and Professor. Dr. Yaksh joined University of California San Diego in 1988 as Professor and Vice Chairman for Research in the Department of Anesthesiology, and Professor in the Department of Pharmacology. His research has been on the biology of pain processing. This work has provided a basis for understanding the pharmacology of the spinal and dorsal root ganglion gating of pain information. He is an expert in spinal drug kinetics and evaluation of spinal drug safety and has published more than 850 papers and edited 6 texts. His work has garnered over 53,000 citations in over 31,000 papers. He has been a mentor to more than 150 postdoctoral fellows and trainees. He has been funded consistently by NIH since 1977 and has twice been a Javitz Award recipient from NIH. Dr. Yaksh has received several honors, including the Kerr Award from the American Pain Society, the Seldon Memorial Lecturer award from the International Anesthesia Research Society, the American Society of Anesthesiologists award for Excellence in Research and the FAER-Helrich lectureship, the Torsten Gordh lecturer award from the Swedish Society of Medicine, the Bonica Award from the International Association for the Study of Pain, and lifetime achievement/service awards from the North American Neuromodulation Society and from European Society of Regional Anesthesia.
A discounted rate of $203 + tax per night is available for attendees. Your reservation includes complimentary full breakfast buffet, evening reception, wi-fi access and airport shuttle. Reserve no later than Wednesday, April 5, 2023
Registration fee includes scientific sessions, reception, lunches and electronic proceedings
DVM / PI Registration $400. Resident / Grad Student $100