Companion Animal Epilepsy

The Companion Animal Epilepsy Research Laboratory is dedicated to discovering more effective treatments for seizures in our companion animals, and learning more about the cause of epileptic seizures in dogs and cats. Our goal is to provide education and outreach to promote a greater understanding of epilepsy and its management while fostering a “One Medicine” approach to benefit both humans and animals with epilepsy.

Epilepsy is the most common chronic neurological disorder in veterinary medicine, and is estimated to affect up to 1% of dogs and 2% of cats in the general population. The term epilepsy is used to describe recurrent seizures that arise due to an abnormality in the brain. The most common cause for recurrent seizures in dogs is idiopathic epilepsy, and many breeds of dogs are genetically predisposed to this disorder. Epilepsy is typically managed with medication directed at controlling the seizures, although the majority of pets do not become seizure free. In these cases, efforts are directed at maximizing seizure control while minimizing treatment related side effects, so as to provide the best quality of life for the pet and the caregiver.

Areas of Study

Epilepsy is a multifaceted disorder. Through partnerships with foundations, industry and other universities, our laboratory studies novel treatment modalities, basis of disease, and improved methods to support pets with epilepsy as well as their caregivers. Much of our work has focused on refractory epilepsy in dogs, evaluating the reasons why dogs might have seizures that are resistant to treatment, as well as exploring methods to achieve better seizure control with medications and alternative forms of therapy.

Each study that we embark upon typically requires many hours of recruitment to locate pets with the specific characteristics needed for a particular study. To help minimize the time and costs associated with this process, we maintain a Nationwide Database of Pets with Epilepsy. If you would like your pet to be included in this listing, please click here. This information will be held confidentially within the laboratory and the listing will not be distributed to others.

Current Clinical Trials

Ongoing Research Studies

Our studies are open to patients of the Veterinary Hospital and beyond. We are continually taking applications for upcoming trials. Click here to browse trials by species or service.

Caregiver Information

A seizure is a transient disturbance in brain function due to abnormal electrical discharge from brain cells. Seizures most frequently manifest as involuntary jerking movements of the head, face and/or limbs. Many animals lose consciousness, and are not aware of their surroundings. Excessive drooling, along with voiding of urine or feces can be seen. Seizures start and stop abruptly, and typically last a few minutes or less. A postictal period follows the seizure, during which animals can be uncoordinated or temporarily blind, and display abnormal behavior such as confusion, disorientation, restlessness, or aggression. The postictal period can last minutes to hours.

There are numerous causes for seizures. These causes are the basis for how seizures are classified.

Reactive seizures result from an imbalance in a substance, originating either within the body or in the environment, that adversely affects the normal brain. This can be due to abnormal function of organs such as the liver or kidney, low blood glucose, or exposure to certain environmental toxins.
Structural epilepsy refers to recurrent seizures that occur secondary to a structural abnormality of the brain such as an infection, stroke or tumor.
Idiopathic epilepsy is the most common cause of seizures in dogs. In this disorder, no underlying cause is identified other than a presumed or proven inherited predisposition.

In the initial evaluation of an animal with seizures, labwork should be performed to identify any abnormalities that might suggest a cause. Additional tests might be recommended by your veterinarian based on age at the onset of seizures, findings of the physical and neurological examination, and results of the initial laboratory tests.

Watching a pet have a seizure can be very disturbing. The best thing to do is remain calm and note the time the seizure begins. Make sure your pet is on the floor to prevent a fall, and protect your pet from water, stairs, children and other pets. Animals are not at risk of swallowing their tongues; do not reach into your pet’s mouth, or place items in the mouth while your pet is having a seizure because you may be accidentally bitten. It is important to time the seizure; if the seizure lasts for longer than 5 minutes or there are multiple seizures in one day, contact your veterinarian or emergency care facility. Keep a seizure diary to record the date, time, seizure length and description. This information will be helpful to your veterinarian as decisions are made regarding treatment.

Treatment is directed at an underlying cause, if one is identified. In addition, treatment with antiseizure drugs is often initiated to help control seizures. It is important to realize that your pet may not become seizure free with treatment. Although this is the overall goal, this is not achievable in some cases, and the focus becomes on reducing the frequency and severity of seizures to an acceptable level. Antiseizure medications can have side effects, and treatment involves finding the right balance to maximize seizure control while minimizing drug related side effects. It is important that antiseizure drugs be administered consistently and at the prescribed dose, as sudden changes can result in seizures. Do not alter your pet’s treatment regimen without first discussing this with your veterinarian.

Epileptic pets are typically normal between seizures and can have a good quality of life and a normal lifespan. It is important for your pet to be evaluated regularly by your veterinarian, to review seizure diaries and evaluate treatment success, screen for any side effects, and discuss any concerns that you have regarding your pet’s care.

First Aid Kit (verify adapted form with FS)

Resources

Publications

Wall of Champions

We wish to acknowledge all of the epileptic dogs that have contributed to our research, as well as their caregivers. This Wall of Champions highlights some of these study participants.