Research Lab – Department of Clinical Sciences
Comparative Pain Research
Contact us: 919.513.6854 | firstname.lastname@example.org or 919.513.6680
- Measurement of acute and chronic pain
- Study of the neurobiological signature of pain in chronic disease
- Evaluation of novel therapeutics for pain relief
- Collaborative work to build on translational models of chronic pain
The laboratory is part of integrated pain management programs at NC State Veterinary Medicine.
A note from Dr. Lascelles: “Sincere thanks to all I’ve worked with to understand and control pain in cats!! Let’s keep going!” Read full article.
- Chronic musculoskeletal pain in cats
Our laboratory continues to work on understanding the prevalence of musculoskeletal pain in cats, the radiographical features, and the etiology of the disease. We are developing valid subjective assessment tools for the assessment of chronic musculoskeletal pain in cats. We also have studies developing objective, non-invasive means of measuring mobility impairment in cats with chronic musculoskeletal pain. We use these tools to evaluate drug and non-drug treatments for musculoskeletal pain in cats. Other collaborative genomic and proteomic work involves elucidating the neurobiology of chronic pain in cats.
- Canine osteoarthritis: a model of human osteoarthritis pain
Canine osteoarthritis is very similar to human osteoarthritis in many respects. We study naturally occurring canine osteoarthritis as a model of the human condition, and also so that our work is directly and immediately relevant to canine clinical pain. We are evaluating aspects of the neurobiology of pain in naturally occurring canine osteoarthritis, as a way of understanding how to better target treatments. Our laboratory uses a variety of validated subjective and objective outcome measures to assess putative analgesic drugs that may be developed for use. We also use these outcome measures to assess and refine current treatments for canine osteoarthritis pain.
- Gastrointestinal tract defense, the role of cyclooxygenase and the effects of combination analgesic regimens on this
We are interested in learning more about the effects of analgesics on gut mucosal health in dogs. These laboratory studies help answer some fundamental and important clinical questions that will help develop safer regimens for analgesic use in dogs. These studies will also help elucidate some of the mechanisms underlying the gastrointestinal adverse effects of drugs and drug combinations in humans. Collaboration with the Gastrointestinal Physiology Lab at NCSU
- Early response of cartilage to trauma
The end result of trauma to joints is osteoarthritis, and this is associated with pain. Understanding the early changes in cartilage in response to trauma may help us prevent or limit cartilage degradation, which leads to progressive joint disease. Collaborative work with the Poultry Genomic Laboratory and Department of Biological and Agricultural Engineering at NCSU uses an ex vivo model of cartilage trauma to understand the early genetic changes involved.
- Evaluation of activity in dogs with osteoarthritis
Wall of Fame
Trial participants are key to our success
Our thanks to all our feline friends that participated in studies to help alleviation of pain in pets! We couldn’t do our research without their participation in our clinical trials. Get to know some of the many wonderful felines who have helped make a difference.
Clinical Metrology Instruments
One goal of the Comparative Pain Research Laboratory is to produce valid clinical metrology instruments for the assessment of pain, physical function and quality of life. These tools are targeted at measuring one or more of the impacts of pain:
- Pain (adverse sensory and emotional experience)
- Mobility (the quality of moving freely)
- Activity (the ability to perform specific activities)
- Affective Effects (mood, feelings)
- International Association for the Study of Pain
- International Veterinary Academy of Pain Management
- European College of Veterinary Surgeons
- American College of Veterinary Surgeons
- American College of Veterinary Emergency and Critical Care
- IASP SIG on Pain and Pain Management in Non-human Species
- University of Liverpool Comparative Musculoskeletal Research Group
Peer-reviewed Research Publications
The important work that has been performed in this laboratory has been made possible by generous donations and research grants awarded. These donations and grants allow us to continue our work improve veterinarians’ ability to alleviate pain in animals, and to use this knowledge in human translational research to assist in the alleviation of pain in humans.
You can support the work of the Comparative Pain Research Laboratory with a tax-deductible donation (please indicate the name of the lab in your gift).
We are very grateful to our current supporters and sponsors for helping us improve the alleviation of pain in dogs and cats:
- American College of Veterinary Surgeons Foundation for the evaluation of a novel method to repair feline pelvic fractures
- Boehringher Ingelheim (competitive grant) to study pain relief in refractory canine osteoarthritis.
- Boehringer Ingelheim to study safer dosing regimens for NSAIDs in dogs.
- Jane T. Gaede
- Mary Jo Pringle
- Mike and Leigh Ann Gallucci
- Morris Animal Foundation (competitive grant) to study the clinical measurement of post-operative pain.
- Morris Animal Foundation to develop a valid chronic pain assessment systems in cats.
- Pharmalink International Limited
- Tina Angelichio
- Winn Feline Foundation