Profile

Immunology, Regenerative Medicine

My research interests are in the use of mesenchymal stem cells for treating inflammatory and immune-mediated diseases. I am currently focused on reducing the immunogenicity of donor mesenchymal stem cells through manipulation of MHC expression to develop more efficient and efficacious regenerative therapies for horses. Additional interests include developing the horse as a large animal translational model for immunology research.

CLINICAL STUDIES

• Obtaining clinical samples of canine melanoma for development of mouse xenografts
• Assessment of the Foresight 5 CsA ring in Dogs with Naturally Occurring Keratoconjunctivitis Sicca
• An alternative to long-lasting elimination diet for the diagnosis of Food Allergy in dogs with Atopic Dermatitis
• Evaluation of a noise abatement strategy for feline friendly housing
• Pilot Evaluationof a Commerical Echocardiographic Contrast AGent to Accurately Dfine the Coronary Artery Anatomy in Dogs with Pulmonic Stenosis
• Characterization of Early and Late Stage Feline CKD Using Contrast-Enhanced Ultrasound and Ultrasound Elastography
• Cancer anorexia cachexia syndrome (CACS) and associated biomarkers in dogs with lymphoma
• Pilot evaluation of the efficacy and safety of anti-IgE therapy for prevention of relapses in atopic dogs with controlled disease.
• Investigating canine lncRNA HOTAIR as a biomarker and novel therapeutic target for canine diffuse large B cell lymphoma
• A pilot dose confirmation study to evaluate the effectiveness and safety of intra-articular injection of CNTX-4975 for the control of pain associated with osteoarthritis in dogs
• Investigating recovery of the skin microbiota after surgery- a pilot study
• Persian, Sphynx and Bengal Cat Hypertrophic Cardiomyopathy
• Mitral Valve Disease in Small Breed Dogs
• Familial arrythmias in Rhodesian Ridgebacks
• Clinical Trials for Dogs and Cats with Urinary Disease
• Boxer Cardiomyopathy and a link to Thyroid Hormone
• Randomized Pilot Trial of 'Movoflex' Supplementation on Biomarkers of Inflammation in Dogs with Degenerative Joint Disease
• Combination of Prednisone, Cobalamin, Loumstine, and Radiation Therapy for Treatment of Feline Gastrointestinal Lymphoblastic Lymphoma (FGLL)
• Efficacy of a New Drug for Treatment of Cats with Ronidazole-Resistant T. foetus infection
• The Microbiota-gut-brain axis in canine epilepsy:determining the role of Lactobacilli (pilot study)
• NV-08 for Canine Pain
• Phase II Study: Immunolight Therapy for Canine Cancer
• Does your dog have urinary incontinence?
• Aqueous humor cytokines in canine glaucoma
• Quantitative assessment of minimal residual disease kinetics during CHOP chemotherapy of canine T-cell lymphoma via next-generation TCRVβ sequencing
• The Effect of Electromagnetic Fields on Post-operative Pain and Recovery of Locomotion in Dogs with Acute Intervertebral Disc Herniations
• The Effect of Post-Operative Rehabilitation on Recovery from Acute Thoracolumbar Intervertebral Disc Herniations
• CLINICAL TRIAL IN DOGS WITH NEWLY DIAGNOSED OSTEOSARCOMA
• Defining the underlying causes of SARDS in dogs
• Incidence of aldosterone breakthrough (ABT) in client-owned dogs receiving angiotensin converting enzyme-inhibitors (ACEI) and/or angiotensin II receptor blockers (ARB) for proteinuric chronic kidney disease (CKDP)
• Conservative Management for Suspected Acute Thoracolumbar Disc Herniations
• Identifying biomarkers to predict outcome of spinal cord injury in dogs
• Pharmacokinetics of levetiracetam XR in Epileptic Dogs When Administered Concurrently with Phenobarbital, Zonisamide, or in Combination
• Music as an add-on therapy for refractory canine epilepsy: A Pilot Study
• Use of Accelerometry to Detect Seizure Activity in Dogs with Idiopathic Epilepsy
• Predictors of response to potassium channel blockade in chronically paralyzed dogs
• Prospective, multicenter, randomized, double-blind, placebo-controlled, 2-parallel groups, phase 3 study to compare efficacy and safety of masitinib to placebo in the treatment of grade 2-3 non-resectable mast cell tumors in dogs not previously treated by chemotherapy (other than corticosteroids) or radiotherapy.
• Regenerative Medicine Approaches to the Treatment of Urinary Incontinence
• Control Dog Recruitment: Impact of Spontaneous Heart Disease on Activity in Dogs
• Investigating Biomarkers of Systemic Inflammation in Equine Colic Referral
• Association Between Hypothyroidism and Boxer Cardiomyopathy
• NC State Equine Colic Database
• Stem cell therapy for equine immune mediated keratitis
• Characterization of signal alterations apparent on magnetic resonance imaging (MRI) using color Doppler
• Evaluation of the effects of exercise on the vascularity of equine metacarpal tendons using Doppler ultrasound
• Healthy Pets Can Help Too!
• Interferon (IFN)-gamma and Tumor Necrosis Factor (TNF)-alpha Concentrations in Inflammed Equine Synoivial Fluid
• Flunixin or Firocoxib for Colic in Horses
• Hind Limb Joint Angle Investigation in AKC Labrador Retrievers and German Shepherd Dogs
• Evaluation of Bed-side Lung Ultrasound for Emergencies (the Vet BLUE Protocol) for emergency evaluation of dyspnea in dogs and cats
• Stem Cell Therapy for Doberman Pinschers with Dilated Cardiomyopathy
• Genetic Study on Cavalier King Charles Spaniels with and without Chiari-like Malformation and Syringomyelia
• Feline Arthritis and NSAID Study
• Neutrophil extracellular traps in IMHA
• Pilot proof of principle: Evaluation of the pain alleviating effects of subcutaneously delivered NV-02 in cats suffering from degenerative joint disease (DJD)-associated pain
• Blood and Urine Sample Collection from Client Owned Cats for a Chronic Kidney Disease Study