David Dorman, DVM, PhD, DABVT, DABT
Dr. Dorman is a diplomate of both the American Board of Veterinary Toxicology and the American Board of Toxicology. Dr. Dorman’s research interests include neurotoxicology, nasal toxicology, pharmacokinetics, and cognition and olfaction in animals. He is an elected fellow of the Academy of Toxicological Sciences and the American Association for the Advancement of Sciences.
He has served on advisory boards for the US Navy, the National Aeronautics and Space Administration, the US Department of Agriculture, and the National Toxicology Program where he served as a member of the NTP’s Board of Scientific Counselors. He has chaired or served on multiple National Academies committees and is a National Associate of the National Academies. His past National Academies service includes chairing the Committee on Endocrine-Related Low Dose Toxicity, the Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures, the Committee on Design and Evaluation of Safer Chemical Substitutions, and the Committee on Potential Health Risks from Recurrent Lead Exposure to DOD Firing Range Personnel.
AffiliationsPresident-elect of the American Board of Veterinary Toxicology
Member, Scientific Advisory Board, North Carolina Department of Environmental Quality and the Department of Health and Human Services.
Member, Federation of American Societies for Experimental Biology Animals in Research and Education Subcommittee.
CertificationsDiplomate of the American Board of Veterinary Toxicology
Diplomate of the American Board of Toxicology
My research and professional interests focus on three broad areas: (a) toxicology; (b) cognition and olfaction; and (c) human risk assessments.
The primary objective of my research is to provide a refined understanding of potential toxicity in humans from exposure to chemicals. Our laboratory has used a combination of in vivo, in vitro, and modeling approaches to accomplish this aim. Research interests has included evaluation of the role that the olfactory system plays in transporting chemicals from the olfactory epithelium directly to the olfactory bulb and other brain structures (‘nose-to-brain’ transport), examining the effect of chemicals on neonates and other potentially sensitive subpopulations; examination of chemically-induced effects on behavior and cognitive development; and the application of dosimetry modeling and other pharmacokinetic methods to chemical risk assessment. We have worked with a wide range of chemicals including manganese, tungsten, the organophosphate fenitrothion, di-butyl phthalate, acrolein, acetaldehyde, hydrogen sulfide, amongst others.
Our laboratory has branched out to evaluate cognition and olfaction in military working dogs. This effort arose in part from our past work examining the effects of chemicals on nasal structure and function in rodents exposed to a variety of inhaled chemicals. Our work sought to improve selection of dogs for use in bomb detection and evaluate olfactory capabilities, learning, and memory in dogs. We have also examined whether early scent exposure to improve scent detection of ammonium nitrate in rats.
External Advisory Service
Member of the North Carolina Scientific Advisory Board on Toxic Air Pollutants
Member of the National Academies’ Board on Environmental Studies and Toxicology
I have primary responsibility for the teaching of the following NCSU courses:
VMB 954: Veterinary Toxicology and Poisonous Plants
VMB 931: Veterinary Ethics and Animal Welfare
VMB 991: What the Nose Knows: Olfaction
VMB 991: Special Topics in Toxicology
BIO 183H: Introductory Biology: Cellular and Molecular Biology (Honors Undergraduate)
- (2018) Olfactory toxicity in rats following manganese chloride nasal instillation: A pilot study.Foster ML, Rao DB, Francher T, Weglinski S, and Dorman DC. | Neurotoxicology (Epub ahead of print).
- (2018) Neonatal C57BL/6J and Parkin mice Respond differently following developmental manganese exposure: Result of a high dose pilot study.Foster ML, Maresca-Fichter HC, Dash M, Mercadante C, Bartnikas TB, and Dorman DC. | Neurotoxicology (Epub ahead of print).
- (2017) Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure.Foster ML, Bartnikas TB, Maresca-Fichter HC, Mercadante C, Dash M, Miller C, and Dorman DC. | Data Brief 15:908-915.
- (2017) Survey of Diplomates of the American Board of Veterinary Toxicology Regarding Perceptions of the Value of This Certification.Dorman DC, Kedrowicz AA. | Int J Toxicol 2017 Sep/Oct;36(5):380-385. Epub 2017 Aug 17.
- (2017) Canine scent detection of canine cancer: A feasibility study.Dorman DC, Foster ML, Fernhoff K, and Hess PR. | Vet Med Res Reports 8: 69-76.
- (2017) Commentary: Fifty years of contributions by the American Board of Veterinary Toxicology.Dorman DC, Beasley VR, and McClellan RO. | J Am Vet Med Assoc 251:268-270.
- (2017) Teaching Tip: Improving Students' Email Communication through an Integrated Writing Assignment in a Third-Year Toxicology Course.Kedrowicz AA, Hammond S, Dorman DC. | J Vet Med Educ Summer 2017;44(2):280-289. Epub 2017 Apr 4.
- (2017) Wearing of a jacketed telemetry system affects behavior in the dog during an open field test.Fish RE, Foster ML, Margaret E. Gruen ME, Sherman BL, and Dorman DC | J Am Assoc Lab Anim Sci 56: 382-389.
- (2017) Caregiver placebo effect in analgesic clinical trials for painful cats with naturally-occurring degenerative joint disease.Gruen ME, Dorman DC, and Lascelles BDX | Vet Rec 180(19) 473.
- (2017) Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing.Hamm J, Sullivan K, Clippinger AJ, Strickland J, Bell S, Bhhatarai B, Blaauboer B, Casey W, Dorman DC, Forsby A, Garcia-Reyero N, Gehen S, Graepel R, Hotchkiss J, Lowit A, Matheson J, Reaves E, Scarano L, Sprankle C | In Vitro Toxicol 41: 245–259.
- (2017) Severity scoring of manganese health effects for categorical regression.Mattison DR, Milton B, Krewski D, Levy L, Dorman DC, Aggett PJ, Roels H, Andersen ME, Karyakina N, Shilnikova N, Ramoju S, and McGough D | Neurotoxicology 58: 203–216.
- (2017) Thromboelastographic monitoring of the effect of unfractionated heparin in healthy dogs.McLaughlin CM, Marks SL, Dorman DC, Motsinger-Reif A, and Hanel RM | J Vet Emer Crit Care 27: 71-81.
- (2016) Best practice recommendations for prehospital veterinary care in dogs and cats.Hanel RM, Palmer L, Baker J, Brenner J, Crowe T, Dorman DC, Gicking J, Gilger B, Otto C, Robertson S, Rozanski E, and Trumpatori B | J Vet Emer Crit Care 26(2): 166–233.
- (2016) Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure.Pettiglio MA, Herrera C, Foster ML, Dorman DC, and Bartnikas TB | Data Brief 6:989-997.
- (2016) Diphenhydramine exposure in dogs: 621 cases (2008-2013)Worth AC, Wismer T, and Dorman DC | J Am Vet Med Assoc 249: 77-82.
- (2016) The effect of high dose oral manganese exposure on copper, iron and zinc levels in rats.Mercadante CJ, Herrera C, Pettiglio MA, Foster ML, Johnson LC, Dorman DC, and Bartnikas TB | Biometals 29: 417-422.
- (2015) Olfactory discrimination and generalization of ammonium nitrate and structurally related odorants in Labrador retrievers.Lazarowski L, Foster ML, Gruen ME, Sherman BL, Milgram NW, and Dorman DC. | Anim Cogn 18: 1255-1266.
- (2015) Pharmacokinetic evaluation of the equivalency of oral routes of manganese exposure in F344 rats.Foster ML, Bartnikas TB, Johnson LC, Herrera C, Pettiglio MA, Keene AM, Taylor MD, and Dorman DC. | Toxicol Sci 145: 244-251.
- (2015) The use of an open field model to assess sound-induced fear and anxiety associated behaviors in Labrador retrievers.Gruen ME, Case BC, Foster ML, Fish RE, Lazarowski L, Landsberg L, Dorman DC, and Sherman BL. | J Vet Behav 10: 338–345.
- (2015) Viewpoint: Chemical alternatives assessments (CAA) at a crossroads.Tickner J, Dorman DC, Shelton-Davenport M. | Environ Sci Technol 49(4):1995-1996.
- (2015) A test for the evaluation of emotional reactivity in Labrador retrievers used for explosives detection.Sherman BL, Gruen ME, Case BC, Foster ML, Fish RE, Lazarowski L, and Dorman DC. | J Vet Behav 10: 94-102.
- (2015) A comparison of pet and purpose-bred research dog (Canis familiaris) performance on human-guided object-choice tasks.Lazarowski L and Dorman DC | Behav Processes. 110:60-67.
- (2015) Feasibility of flotation concentration of fungal spores as a method to identify toxigenic mushrooms.Bazzle LJ, Cubeta MA, Marks SL, and Dorman DC | Vet Med Res Reports 6: 1-9
- (2015) Extrapyramidal system neurotoxicity: animal models.Dorman DC. | Handbook of Clinical Neurology Vol 131 Occupational Neurology, Lotti M and Bleecker ML (Eds) Elsevier pp 207-223.
- (2015) Olfactory transport of manganese: Implications for neurotoxicity.Dorman DC and Foster ML | Manganese in Health and Disease Costa L and Aschner M (eds). RSC Publishing, Cambridge, UK pp 119-132.
- (2014) Evaluation of a point-of-care anticoagulant rodenticide test for dogs.Istvan SA, Marks SL. Murphy LA, Dorman DC . | J Vet Emerg Crit Care (San Antonio) 24(2):168-73, 2014
- (2014) Explosives detection by military working dogs: Olfactory generalization from components to mixtures.Lazarowski L and Dorman DC | Appl Anim Behav Sci 151: 84-93.
- (2014) Acquisition of a visual discrimination and reversal learning task by Labrador retrievers.Lazarowski L, Foster ML, Gruen ME, Sherman BL, Case BC, Fish RE, Milgram NW, and Dorman DC | Anim Cogn 17(3):787-792.
- (2013) Assessment of geographical variation in the respiratory toxicity of desert sand particles.Taylor K, Foster ML, Law JM, Centeno JA, Fornero E, Henderson MS Jr., Trager SA Stockelman MG, and Dorman DC | Inhal Toxicol 25(7):405-16.
- (2013) Inhalation dosimetry of hexamethylene diisocyanate vapor in the rat and human respiratory tracts.Schroeter JD, Kimbell JS, Asgharian B, Tewksbury EW, Sochaski M, Foster ML, Dorman DC, Wong BA, and Andersen MA | Inhal Toxicol 25(3):168-77.
- (2013) Subject matter expert and public evaluations of a veterinary toxicology course brochure writing assignment.Dorman DC, Alpi KM, and Chappell KH | J Vet Med Educ 40(1):19-28.
What the Nose KnowsA team of researchers at NC State put the olfactory prowess of dogs to a new test – whether dogs can reliably detect certain forms of cancer...
Dorman Named National Associate of the National AcademiesNational Associates are recognized for their extraordinary contributions to the National Academies through pro bono service to NRC and Institute of Medicine programs...
Dorman Elected to one of the World’s Most Important Scientific SocietiesProfessor David Dorman has been elected as a Fellow of the American Association for the Advancement of Science (AAAS)...
NC State Toxicology Professor Elected Fellow of the American Association for the Advancement of Science
David Dorman, a professor of toxicology in North Carolina State University’s College of Veterinary Medicine, has been elected as a Fellow of the American Association for the Advancement of Science (AAAS), one of the world’s most important scientific societies and publisher of the journal Science. AAAS elevates members to the rank of Fellow for their efforts toward advancing science applications
CVM Toxicology Professor Chairs National Research Council Committee on Evaluating Safer Chemicals
Chemicals used in consumer products and industrial processes have elicited concerns in recent years about impacts on health or the environment, prompting manufacturers, retailers, and regulators to develop methods for evaluating potentially safer chemical substitutes. Although a number of assessment tools exist, they reflect a range of different priorities, such as a focus on protecting