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Profile

David Dorman, DVM, PhD, DABVT, DABT

Professor, Toxicology

Contact:

david_dorman@ncsu.edu
Office: 919.513.6237

Dr. David Dorman is a professor of toxicology in the Department of Molecular Biosciences of North Carolina State University. He received his DVM from Colorado State University. He completed a combined PhD and residency program in toxicology at the University of Illinois at Urbana-Champaign. Dorman has served on numerous National Academies committees. He currently chairs the National Academies’ Committee on Toxicology and the Committee on Endocrine-Related Low Dose Toxicity. He recently chaired the National Academies Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures and the Committee on Design and Evaluation of Safer Chemical Substitutions - A Framework to Inform Government and Industry Decisions. He previously served as a member of the National Toxicology Program’s Board of Scientific Counselors. He has also served on other advisory boards for the US Navy, NASA, and USDA. He is an elected fellow of the Academy of Toxicological Sciences and he is a fellow of the American Association for the Advancement of Sciences.
Affiliations
National Toxicology Program Board of Scientific Counselors
North Carolina Scientific Advisory Board on Toxic Air Pollutants
National Resource Council (member of several boards and committees)
Certifications
Diplomate, American College of Veterinary Toxicology
Neurobiology
My research and professional interests focus on three broad areas: (a) toxicology; (b) cognition and olfaction; and (c) human risk assessments.
The primary objective of my research is to provide a refined understanding of potential toxicity in humans from exposure to chemicals. Our laboratory has used a combination of in vivo, in vitro, and modeling approaches to accomplish this aim. Research interests has included evaluation of the role that the olfactory system plays in transporting chemicals from the olfactory epithelium directly to the olfactory bulb and other brain structures (‘nose-to-brain’ transport), examining the effect of chemicals on neonates and other potentially sensitive subpopulations; examination of chemically-induced effects on behavior and cognitive development; and the application of dosimetry modeling and other pharmacokinetic methods to chemical risk assessment. We have worked with a wide range of chemicals including manganese, tungsten, the organophosphate fenitrothion, di-butyl phthalate, acrolein, acetaldehyde, hydrogen sulfide, amongst others.
Our laboratory has branched out to evaluate cognition and olfaction in military working dogs. This effort arose in part from our past work examining the effects of chemicals on nasal structure and function in rodents exposed to a variety of inhaled chemicals. Our work sought to improve selection of dogs for use in bomb detection and evaluate olfactory capabilities, learning, and memory in dogs. We have also examined whether early scent exposure to improve scent detection of ammonium nitrate in rats.

External Advisory Service
Former member of the National Toxicology Program Board of Scientific Counselors
Member of the North Carolina Scientific Advisory Board on Toxic Air Pollutants
Member of the National Academies’ Board on Environmental Studies and Toxicology
Chairman of the National Academies’ Committee on Toxicology)
Chairman of the National Academies’ Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures

Teaching
I have primary responsibility for the teaching of the following NCSU courses:
VMB 954: Veterinary Toxicology and Poisonous Plants
VMB 931: Veterinary Ethics and Animal Welfare
VMB 991: What the Nose Knows: Olfaction
VMB 991: Special Topics in Toxicology
BIO 183H: Introductory Biology: Cellular and Molecular Biology (Honors Undergraduate)
  • (2016) Wearing of a jacketed telemetry system affects behavior in the dog during an open field test.Fish RE, Foster ML, Margaret E. Gruen ME, Sherman BL, and Dorman DC | J Am Assoc Lab Anim Sci (submitted)
  • (2016) Caregiver placebo effect in analgesic clinical trials for painful cats with naturally-occurring degenerative joint disease.Gruen ME, Dorman DC, and Lascelles BDX | Vet Rec (submitted)
  • (2016) Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing.Hamm J, Sullivan K, Clippinger AJ, Strickland J, Bell S, Bhhatarai B, Blaauboer B, Casey W, Dorman DC, Forsby A, Garcia-Reyero N, Gehen S, Graepel R, Hotchkiss J, Lowit A, Matheson J, Reaves E, Scarano L, Sprankle C | In Vitro Toxicol (submitted)
  • (2016) Teaching tip: Improving students' email communication through an integrated writing assignment in a third-year toxicology course".Kedrowicz AA, Hammond S, and Dorman DC | J Vet Med Educ (submitted)
  • (2016) Evidence of rebound hypercoagulability following abrupt withdrawal of heparin in healthy dogs: A pilot study.Mays EM, Dorman DC, McKendry C, and Hanel RM | J Vet Emer Crit Care (submitted)
  • (2016) Severity scoring of manganese health effects for categorical regression.Mattison DR, Milton B, Krewski D, Levy L, Dorman DC, Aggett PJ, Roels H, Andersen ME, Karyakina N, Shilnikova N, Ramoju S, and McGough D | Neurotoxicology (in press)
  • (2016) Thromboelastographic monitoring of the effect of unfractionated heparin in healthy dogs.McLaughlin CM, Marks SL, Dorman DC, Motsinger-Reif A, and Hanel RM | J Vet Emer Crit Care (in press)
  • (2016) Best practice recommendations for prehospital veterinary care in dogs and cats.Hanel RM, Palmer L, Baker J, Brenner J, Crowe T, Dorman DC, Gicking J, Gilger B, Otto C, Robertson S, Rozanski E, and Trumpatori B | J Vet Emer Crit Care 26(2): 166–233.
  • (2016) Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure.Pettiglio MA, Herrera C, Foster ML, Dorman DC, and Bartnikas TB | Data Brief 6:989-997.
  • (2016) Diphenhydramine exposure in dogs: 621 cases (2008-2013)Worth AC, Wismer T, and Dorman DC | J Am Vet Med Assoc 249: 77-82.
  • (2016) The effect of high dose oral manganese exposure on copper, iron and zinc levels in rats.Mercadante CJ, Herrera C, Pettiglio MA, Foster ML, Johnson LC, Dorman DC, and Bartnikas TB | Biometals 29: 417-422.
  • (2015) Olfactory discrimination and generalization of ammonium nitrate and structurally related odorants in Labrador retrievers.Lazarowski L, Foster ML, Gruen ME, Sherman BL, Milgram NW, and Dorman DC. | Anim Cogn 18: 1255-1266.
  • (2015) Pharmacokinetic evaluation of the equivalency of oral routes of manganese exposure in F344 rats.Foster ML, Bartnikas TB, Johnson LC, Herrera C, Pettiglio MA, Keene AM, Taylor MD, and Dorman DC. | Toxicol Sci 145: 244-251.
  • (2015) The use of an open field model to assess sound-induced fear and anxiety associated behaviors in Labrador retrievers.Gruen ME, Case BC, Foster ML, Fish RE, Lazarowski L, Landsberg L, Dorman DC, and Sherman BL. | J Vet Behav 10: 338–345.
  • (2015) Viewpoint: Chemical alternatives assessments (CAA) at a crossroads.Tickner J, Dorman DC, Shelton-Davenport M. | Environ Sci Technol 49(4):1995-1996.
  • (2015) A test for the evaluation of emotional reactivity in Labrador retrievers used for explosives detection.Sherman BL, Gruen ME, Case BC, Foster ML, Fish RE, Lazarowski L, and Dorman DC. | J Vet Behav 10: 94-102.
  • (2015) A comparison of pet and purpose-bred research dog (Canis familiaris) performance on human-guided object-choice tasks.Lazarowski L and Dorman DC | Behav Processes. 110:60-67.
  • (2015) Feasibility of flotation concentration of fungal spores as a method to identify toxigenic mushrooms.Bazzle LJ, Cubeta MA, Marks SL, and Dorman DC | Vet Med Res Reports 6: 1-9
  • (2015) Extrapyramidal system neurotoxicity: animal models.Dorman DC. | Handbook of Clinical Neurology Vol 131 Occupational Neurology, Lotti M and Bleecker ML (Eds) Elsevier pp 207-223.
  • (2015) Olfactory transport of manganese: Implications for neurotoxicity.Dorman DC and Foster ML | Manganese in Health and Disease Costa L and Aschner M (eds). RSC Publishing, Cambridge, UK pp 119-132.
  • (2014) Evaluation of a point-of-care anticoagulant rodenticide test for dogs.Istvan SA, Marks SL. Murphy LA, Dorman DC . | J Vet Emerg Crit Care (San Antonio) 24(2):168-73, 2014
  • (2014) Explosives detection by military working dogs: Olfactory generalization from components to mixtures.Lazarowski L and Dorman DC | Appl Anim Behav Sci 151: 84-93.
  • (2014) Acquisition of a visual discrimination and reversal learning task by Labrador retrievers.Lazarowski L, Foster ML, Gruen ME, Sherman BL, Case BC, Fish RE, Milgram NW, and Dorman DC | Anim Cogn 17(3):787-792.
  • (2013) Assessment of geographical variation in the respiratory toxicity of desert sand particles.Taylor K, Foster ML, Law JM, Centeno JA, Fornero E, Henderson MS Jr., Trager SA Stockelman MG, and Dorman DC | Inhal Toxicol 25(7):405-16.
  • (2013) Inhalation dosimetry of hexamethylene diisocyanate vapor in the rat and human respiratory tracts.Schroeter JD, Kimbell JS, Asgharian B, Tewksbury EW, Sochaski M, Foster ML, Dorman DC, Wong BA, and Andersen MA | Inhal Toxicol 25(3):168-77.
  • (2013) Subject matter expert and public evaluations of a veterinary toxicology course brochure writing assignment.Dorman DC, Alpi KM, and Chappell KH | J Vet Med Educ 40(1):19-28.