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Santosh Mishra, M.Tech., PhD

Associate Professor

Office: 919.515.2152

Dr. Mishra obtained his bachelor’s degree from Delhi University (India) followed by his master’s degree in Biotechnology at Agra University. He further pursued his second master (M.Tech.) from Anna University (Chennai), one of the premier Universities in India for Engineering. He obtained his Ph.D. from Institute for Cell Biology and Neuroscience at the Johann Wolfgang Goethe University, Frankfurt, Germany.

He worked in the area of Neural Stem Cells (NSC) during his Ph.D. and identified the expression of ecto- enzymes NTPDase2 (hydrolyzes ATP into ADP) in NSC present in the sub-ventricular zone of the adult rodent brain. Dr. Mishra revealed the first evidence that purinergic receptors and its ligands are involved in NSC proliferation and differentiation. German Research Foundation fully supported his Ph.D. research work as an international student.

After completing his Ph.D., he moved to the National Institute of Dental and Craniofacial Research (NIH) to work with Dr. Mark Hoon as a postdoctoral fellow and was eventually promoted as a Staff Scientist within the same lab. His post-doctoral work was on somatosensation particularly pain and itch. Dr. Mishra’s recent findings were to elucidate the neural circuit for itch sensation in mice that received worldwide attention for his research work. Additionally,

Dr. Mishra has authored numerous high-impact research articles during his research at Frankfurt as well as at NIH and is a recipient of several awards.
Society for Neuroscience
International Brain Research Organization
National Institutes of health, Clinical Center, Bethesda/ USA, 2010
Demystifying Medicine
National Institutes of health, Clinical Center, Bethesda/ USA, 2009
Translational Research in Clinical Oncology
National Institutes of health, Clinical Center, Bethesda/ USA, 2008
Principle and Practice of Clinical Research
1) Investigate the cellular and molecular mechanisms underlying chronic itch and possibly pain in mice
2) To characterize the subtype of itch and pain-responsive neurons in the spinal cord
3) Tracing the neural circuit for itch sensation in the spinal cord and CNS
4) Discover the degree to which specific mechanisms of itch are conserved across mammalian species.

The Mishra lab will use a wide range of powerful new tools to address these questions including molecular genetics, deep sequencing, functional imaging, electrophysiology and optogenetics along with pharmacological and behavioral tools.
  • (2014) Molecular signatures of TRPV1 nociceptive neurons revealed by RNA-Seq of rat and mouse DRG transcriptomesGoswami SC, Mishra SK, Maric D, Kaszas K, Gonnella GL, Clokie SJ, Kominski DH, Gross JR, Keller JK, Mannes AJ, Hoon MA, Iadarola MJ | J. of Pain 2014 Dec;15(12):1338-59
  • (2013) The Cells and Circuitry for Itch Responses in MiceMishra SK and Hoon MA | Science May 24, Vol.340 no. 6135 pp. 968-971
  • (2013) The cellular code for mammalian thermosensationPogorzalla L, Mishra SK and Hoon MA | Journal of Neuroscience March 27;33(13):5533-41
  • (2013) A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice.Shukla V, Zheng YL, Mishra SK, Amin ND, Steiner J, Grant P, Kesavapany S and Pant HC | FASEB J Jan; 27(1):174-86.
  • (2012) Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pHKaszas K, Keller JM, Coddou C, Mishra S, Hoon M, Stojilkovic S, Kenneth A. Jacobson KA and Iadarola MJ | Journal of pharmacological and experimental therapeutics 340(1):152-60
  • (2012) A nociceptive signaling role for neuromedin BMishra SK, Holzman S and Hoon MA | Journal of Neuroscience 32(25):8686-95
  • (2011) TrpV1-lineage neurons are required for thermal sensationMishra SK, Tisel S, Orestes P, Bhangoo S, Hoon M | The EMBO Journal 30, 582-93
  • (2011) Oxidative stress in neurodegenerationShukla V, Mishra SK and Pant H.C | Advances in Pharmacological sciences 2011:572634. (review)
  • (2010) Ablation of TrpV1 neurons reveal their selective role in thermal pain sensationMishra SK & Hoon MA | Molecular and Cellular Neuroscience Vol 43. P. 167-172
  • (2005) Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferationMishra SK, Braun N, Shukla V, Füllgrabe M, Schomerus C, Korf HW, Gachet C, Ikehara Y, Sevigny J, Robson SC, Zimmermann H | Development 133 (4) 675-684