Santosh Mishra, M.Tech., PhD
He worked in the area of Neural Stem Cells (NSC) during his Ph.D. and identified the expression of ecto- enzymes NTPDase2 (hydrolyzes ATP into ADP) in NSC present in the sub-ventricular zone of the adult rodent brain. Dr. Mishra revealed the first evidence that purinergic receptors and its ligands are involved in NSC proliferation and differentiation. German Research Foundation fully supported his Ph.D. research work as an international student.
After completing his Ph.D., he moved to the National Institute of Dental and Craniofacial Research (NIH) to work with Dr. Mark Hoon as a postdoctoral fellow and was eventually promoted as a Staff Scientist within the same lab. His post-doctoral work was on somatosensation particularly pain and itch. Dr. Mishra’s recent findings were to elucidate the neural circuit for itch sensation in mice that received worldwide attention for his research work. Additionally,
Dr. Mishra has authored numerous high-impact research articles during his research at Frankfurt as well as at NIH and is a recipient of several awards.
AffiliationsSociety for Neuroscience
International Brain Research Organization
CertificationsNational Institutes of health, Clinical Center, Bethesda/ USA, 2010
National Institutes of health, Clinical Center, Bethesda/ USA, 2009
Translational Research in Clinical Oncology
National Institutes of health, Clinical Center, Bethesda/ USA, 2008
Principle and Practice of Clinical Research
Neurobiology1) Investigate the cellular and molecular mechanisms underlying chronic itch and possibly pain in mice
2) To characterize the subtype of itch and pain-responsive neurons in the spinal cord
3) Tracing the neural circuit for itch sensation in the spinal cord and CNS
4) Discover the degree to which specific mechanisms of itch are conserved across mammalian species.
The Mishra lab will use a wide range of powerful new tools to address these questions including molecular genetics, deep sequencing, functional imaging, electrophysiology and optogenetics along with pharmacological and behavioral tools.
- (2014) Molecular signatures of TRPV1 nociceptive neurons revealed by RNA-Seq of rat and mouse DRG transcriptomesGoswami SC, Mishra SK, Maric D, Kaszas K, Gonnella GL, Clokie SJ, Kominski DH, Gross JR, Keller JK, Mannes AJ, Hoon MA, Iadarola MJ | J. of Pain 2014 Dec;15(12):1338-59
- (2013) The Cells and Circuitry for Itch Responses in MiceMishra SK and Hoon MA | Science May 24, Vol.340 no. 6135 pp. 968-971
- (2013) The cellular code for mammalian thermosensationPogorzalla L, Mishra SK and Hoon MA | Journal of Neuroscience March 27;33(13):5533-41
- (2013) A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice.Shukla V, Zheng YL, Mishra SK, Amin ND, Steiner J, Grant P, Kesavapany S and Pant HC | FASEB J Jan; 27(1):174-86.
- (2012) Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pHKaszas K, Keller JM, Coddou C, Mishra S, Hoon M, Stojilkovic S, Kenneth A. Jacobson KA and Iadarola MJ | Journal of pharmacological and experimental therapeutics 340(1):152-60
- (2012) A nociceptive signaling role for neuromedin BMishra SK, Holzman S and Hoon MA | Journal of Neuroscience 32(25):8686-95
- (2011) TrpV1-lineage neurons are required for thermal sensationMishra SK, Tisel S, Orestes P, Bhangoo S, Hoon M | The EMBO Journal 30, 582-93
- (2011) Oxidative stress in neurodegenerationShukla V, Mishra SK and Pant H.C | Advances in Pharmacological sciences 2011:572634. (review)
- (2010) Ablation of TrpV1 neurons reveal their selective role in thermal pain sensationMishra SK & Hoon MA | Molecular and Cellular Neuroscience Vol 43. P. 167-172
- (2005) Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferationMishra SK, Braun N, Shukla V, Füllgrabe M, Schomerus C, Korf HW, Gachet C, Ikehara Y, Sevigny J, Robson SC, Zimmermann H | Development 133 (4) 675-684
A Breakthrough in Understanding Canine Itch
A new study from the NC State College of Veterinary Medicine is the first to pinpoint the intricate pathway mechanisms of itch in dogs, information vital to developing targeted treatments for common and chronic canine skin disorders. The research describes the expression of itch-signaling somatostatin and other major itch-associated neuropeptides and receptors in canine neurons.
Inflammation Amps Up Neurite Growth, Gene Expression Involved in Heat, Cold Sensitivity
Researchers from North Carolina State University have found that inflammation increases neuronal activity, gene expression and sensory nerve (neurite) outgrowth in neurons involved in thermal – but not physical– sensations in mice. The work sheds light on the role that inflammation-induced overexpression of calcium channel genes may play in pain hypersensitivity. Inflammation can often cause
Flipping the Switch on Itch: Researchers Identify Neuropeptide Involved in Transmitting Itch Signal to Brain in Eczema
Researchers from North Carolina State University have pinpointed a particular neuropeptide associated with transmitting itch signals in mice with atopic dermatitis. The work sheds further light on the pathways involved in transmitting itch sensations from the peripheral (skin) to the central (spinal cord) nervous system. “You can think of itch being transmitted from the skin
Scratching the Surface of Itch
Santosh Mishra is an assistant professor in the Department of Molecular Biomedical Sciences. He studies the neurological pathways involved in itch, in order to help us understand why and how we feel this sensation. He was recently involved in an international research collaboration aimed at identifying the process by which itch sensations are transmitted to the brain.
Neuroscientists Find ‘Gatekeeper’ in Itching Sensations Plays No Role in Pain Transmission
A study from North Carolina State University researchers shows that a neurotransmitter involved in relaying itching sensations from the skin to the spinal cord and into the brain plays no role in pain transmission. “For us, it’s very important to understand the neural circuits or pathways so that we can develop therapies specifically for pain
Fatty Acids and Itchy Skin – a Q&A with Santosh Mishra
Santosh Mishra, assistant professor of neuroscience at NC State Veterinary Medicine, was part of a team of NIH researchers who have discovered four previously unknown mediators for itch and pain in the skin. Identifying these mediators may be a first step toward providing relief for people who suffer from chronic skin conditions such as psoriasis.