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Nanette Nascone-Yoder, PhD

Associate Professor, Developmental Biology

Contact:

nmnascon@ncsu.edu
Office: 919.513.8284
Lab: Digestive Track Development
Lab Phone: 919.513.8284

Nanette Nascone-Yoder obtained her BS in Molecular Biology from Eckerd College, and Ph.D. in Cell and Developmental Biology at Harvard University.

Dr. Nascone-Yoder established her laboratory at NC State's College of Veterinary Medicine in 2006 and was selected as a University Faculty Scholar in 2013. As an Associate Professor in the Department of Molecular Biomedical Sciences, Dr. Nascone-Yoder's research is at the intersection of development, evolution and toxicology. Her lab focuses on discovering the cellular and molecular mechanisms by which organs become left-right asymmetric, as a way to understand the causes of laterality-related birth defects. The Nascone-Yoder lab recently pioneered the use of a novel model organism for the study of organogenesis, the Budgett's frog. The lab's research has been funded by the National Science Foundation, National Institutes of Health and American Heart Association, and recommended by Faculty of 1000.
Affiliations
Comparative Medicine Institute, Center for Human Health and the Environment, Society for Developmental Biology
Certifications
Ph.D., Harvard University, 1997
Assistant Professor, Eckerd College, 1997, tenured 2003
Associate Professor, Eckerd College, 2004
Biological Barriers
Morphogenesis, organogenesis, digestive organs, left-right asymmetry
  • (2017) Stomach curvature is generated by left-right asymmetric gut morphogenesis.Davis, A., Amin, N., Bagley, K., Johnson, C., Ghashghaei, T. and N. Nascone-Yoder | Development, 144(8):1477-1483.
  • (2017) A non-neuronal, non-enzymatic role for acetylcholinesterase in vertebrate gut morphogenesis.Pickett, M. and N. Nascone-Yoder | Development, 144(15): 2764-2770.
  • (2016) Frogs as integrative models for understanding digestive organ development and evolution.Womble, M., Pickett, M., and N. Nascone-Yoder | Seminars in Cell and Developmental Biology, 51:92-105.
  • (2015) Budgett's frog (Lepidobatrachus laevis): a new amphibian embryo for developmental biology.Amin N., Womble M., Ledon-Rettig, C., Hull, M., Dickenson, A. and N. Nascone-Yoder | Developmental Biology, 405(2):291-303.
  • (2003) Left and right contributions to the Xenopus heart: implications for asymmetric morphogenesisGormley, J.P. and N. Nascone-Yoder | Development, Genes and Evolution 213, 390-398
  • (2014) A single codon insertion in PICALM is associated with development of familial subvalvular aortic stenosis in Newfoundland dogs.Stern JA, White SN, Lehmkuhl LB, Reina-Doreste Y, Ferguson JL, Nascone-Yoder NM, Meurs KM. | Human Genetics, 133(9):1139-48.
  • (2013) Jun N-terminal kinase maintains tissue integrity during cell rearrangement in the gut.Dush, M. and N. Nascone-Yoder | Development, 140(7): 1457-66.
  • (2013) Developmental origins of a novel gut morphology in frogs.Bloom, S., Ledon-Rettig, C., Infante, C., Everly, A., Hanken, J. and N. Nascone-Yoder | Evolution and Development, 15(3): 213-223.
  • (2013) Constraints on mammalian forelimb development: Insights from developmental disparity.Ross, D., Marcot, J., Betteridge, K., Nascone-Yoder, N., Bailey, C. S. and Sears, K. | Evolution, 67(12):3545-52.
  • (2012) A photoactivatable small molecule for spatiotemporal control of Rho-associated Kinase activity in living embryos.Morckel, A. Young, D., Deiters, A. and N. Nascone-Yoder | Development, 139(2):437-442.
  • (2011) Heterotaxin: A TGF-β Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus EmbryosDush, M.K., A.L. McIver, M.A. Parr, D.D. Young, J. Fisher, D.R. Newman, P.L. Sannes, M.L. Hauck, A. Deiters, N. Nascone-Yoder | Chem.Biol. 2011.18:252-263.
  • (2010) Direct activation of Shroom3 transcription by Pitx proteins drives epithelial morphogenesis in the developing gutMei-I Chung, Nanette M Nascone-Yoder, Stephanie A Grover, Thomas A Drysdale, John B Wallingford | Development 137: 8. 1339-1349
  • (2009) Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangementsRachel A Reed, Mandy A Womble, Michel K Dush, Rhesa R Tull, Stephanie K Bloom, Allison R Morckel, Edward W Devlin, Nanette M Nascone-Yoder | Dev Dyn 238: 12. 3111-3125
  • (2008) Ancestral variation and the potential for genetic accommodation in larval amphibians: implications for the evolution of novel feeding strategiesLedon-Rettig CC, Pfennig DW, Nascone-Yoder N | Evolution and Development 10(3):316-25
  • (2006) A role for retinoid signaling in left-right asymmetric digestive organ morphogenesisLipscomb, K.J., Sablyak, A.R., Schmitt, C.E., Yoder, J.A. and N. Nascone-Yoder | Developmental Dynamics 235(8):2266-75
  • (2003) left-right asymmetric morphogenesis in the Xenopus digestive systemMuller, J.K., Prather, D. and N. Nascone-Yoder | Developmental Dynamics 228(4):672-82
  • (2000) The evolutionary relationships between the amphibian, avian and mammalian stomachsSmith, D., R.C. Grasty, C.J. Tabin, and N. Nascone-Yoder | Evolution and Development 2 (6), 348-359
  • (1997) Organizer induction determines left-right asymmetry in XenopusNascone, N. and M. Mercola | Developmental Biology 189, 68-78
  • (1997) Two molecular models of initial left-right asymmetry generationLevin, M. and N. Nascone | Medical Hypotheses 49, 429-435
  • (1996) Endoderm and cardiogenesis: new insightsNascone, N. and M. Mercola | Trends in Cardiovascular Medicine 6, 211-216
  • (1995) An inductive role for the endoderm in Xenopus cardiogenesisNascone, N. and M. Mercola | Development 121, 515-523