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Barbara Sherry, PhD

Professor, Virology

Contact:

barbara_sherry@ncsu.edu
Office: 919.515.4480

We study reovirus-induced myocarditis (cardiac inflammation and tissue damage) in mice as a model for this important human disease. Recently, we have focused on the cardiac response to viral infection, with particular emphasis on viral induction of the antiviral cytokine interferon-beta in cardiac cells. We are interested in both the viral genes that stimulate this response, and the cardiac transcription factors and antiviral proteins that are central to protection against disease. Our approaches, using primarily molecular techniques, include the use of transgenic mice and primary cardiac myocyte cell cultures. This research is funded primarily by NIH.

Lab Members
Graduate Students: Efraín Rivera-Serrano, Nicole DeAngelis
Research Specialist: Shannon Chiera

Infectious Diseases
We study viral infections of the heart to identify the viral and host determinants of cardiac damage. Viral myocarditis is indicated as the second leading cause of sudden death in young adults. While viruses can induce immune-mediated pathology, it is likely that most viruses induce damage by directly injuring cardiac cells. Reovirus-induced myocarditis in neonatal mice reflects direct injury to the heart and offers an outstanding model for investigation. We use a wide range of approaches in vivo and in primary cardiac cell cultures to probe antiviral cell responses, particularly those that are unique to cardiac cells. We have found that the Type I interferon (IFN) response is an important determinant of protection against viral myocarditis. Our current investigations focus on: 1) the cardiac IFN response, 2) reovirus subversion of the IFN response, and 3) novel therapeutic approaches for viral myocarditis.


  • 2010.   Interferon regulatory factor-3 attenuates reovirus myocarditis and contributes to viral clearanceHolm, G.H., A.J. Pruijssers, L. Li, P. Danthi, B. Sherry,and T.S. Dermody | Journal of Virology 84(14):6900 – 6908
  • 2010.  Proteomic analysis reveals virus-specific Hsp25 modulation in cardiac myocytesLi, L., J.R. Sevinsky, M.D. Rowland, J.L. Bundy, J.L. Stephenson and B. Sherry | Journal of Proteome Research 9(5):2460-2471
  • 2010.  IFN-a expression and antiviral effects are subtype- and cell type-specific in the cardiac response to viral infectionLi, L. and B. Sherry | Virology 396:59-68
  • 2009.  Reovirus and rotavirus modulation of the interferon responseSherry, B | Journal of Interferon and Cytokine Research 29(9):559-567
  • 2009.  The Reovirus mu2 Protein Inhibits Interferon Signaling Through a Novel Mechanism Involving Nuclear Accumulation of Interferon Regulatory Factor-9Zurney, J., T. Kobayashi, G.H. Holm, T.S. Dermody, and B. Sherry. | Journal of Virology 83:2178-2187
  • 2007.  Basal expression of IFNAR and Jak-STAT components are determinants of cell type-specific differences in the cardiac antiviral responseZurney, J., K.E. Howard, and B. Sherry | Journal of Virology 81:13668-13680
  • 2007.  RIG-I and IPS-1 augment proapoptotic responses following mammalian reovirus infection via IRF-3Holm, G.H., J. Zurney, V. Tumilasci, S. Leveille, P. Danthi, J. Hiscott, B. Sherry, and T.S. Dermody | The Journal of Biological Chemistry 282(30):21953-61
  • 2005.  Organ-specific roles for transcription factor NF-kB in reovirus-induced apoptosis and diseaseO’Donnell, S.M., M.W. Hansberger, J.L. Connolly, J.D. Chappell, M.J. Watson, J.M. Pierce, W. Han, E.S. Barton, J.C. Forrest, T. Valyi-Nagy, F.E. Yull, T.S. Blackwell, J.N. Rottman, B. Sherry, and T.S. Dermody | The Journal of Clinical Investigation 115(9): 2341-2350
  • 2005. Basal and reovirus-induced intereferon-b (IFN-b) and IFN-b-stimulated gene expression are cell type-specific in the cardiac protective responseStewart, M.J., K. Smoak, M.A. Blum, and B Sherry | J. Virology 79(5):2979-2987
  • 2012. A Single Amino Acid Polymorphism in Reovirus Protein µ2 Determines Repression of Interferon Signaling and Modulates MyocarditisIrvin, S.C., J. Zurney, L.S. Ooms, J.D. Chappell, T.S. Dermody, and B Sherry | Journal of Virology 86(4):2302-2311
  • 2005. Basal and reovirus-induced intereferon-b (IFN-b) and IFN-b-stimulated gene expression are cell type-specific in the cardiac protective responseStewart, M.J., K. Smoak, M.A. Blum, and B Sherry | J. Virology 79(5):2979-2987