Barbara Sherry, PhD
Department Head, Molecular Biomedical Sciences
We study reovirus-induced myocarditis (cardiac inflammation and tissue damage) in mice as a model for this important human disease. Recently, we have focused on the cardiac response to viral infection, with particular emphasis on viral induction of the antiviral cytokine interferon-beta in cardiac cells. We are interested in both the viral genes that stimulate this response, and the cardiac transcription factors and antiviral proteins that are central to protection against disease. Our approaches, using primarily molecular techniques, include the use of transgenic mice and primary cardiac myocyte cell cultures. This research is funded primarily by NIH.
Infectious DiseasesWe study viral infections of the heart to identify the viral and host determinants of cardiac damage. Viral myocarditis is indicated as the second leading cause of sudden death in young adults. While viruses can induce immune-mediated pathology, it is likely that most viruses induce damage by directly injuring cardiac cells. Reovirus-induced myocarditis in neonatal mice reflects direct injury to the heart and offers an outstanding model for investigation. We use a wide range of approaches in vivo and in primary cardiac cell cultures to probe antiviral cell responses, particularly those that are unique to cardiac cells. We have found that the Type I interferon (IFN) response is an important determinant of protection against viral myocarditis. Our current investigations focus on: 1) the cardiac IFN response, 2) reovirus subversion of the IFN response, and 3) novel therapeutic approaches for viral myocarditis.
Research Specialist: Shannon Chiera
- Barbara Sherry NCBI Publications
View online at NCBI MyBibliography |
- 2017. Spontaneous Activation of a MAVS-dependent Antiviral Signaling Pathway Determines High Basal Interferon-β Expression in Cardiac Myocytes.Rivera-Serrano, E.E. and B. Sherry | Journal of Molecular and Cellular Cardiology 111:102-113.
- 2017. A cytoplasmic RNA virus alters the function of the cell splicing protein SRSF2.Rivera-Serrano, E.E., E.J Fritch, E.H Scholl, and B. Sherry | Journal of Virology 91(7): e02488-16.
- 2017. NF-κB activation is cell type-specific in the heart.Rivera-Serrano, E.E., and B. Sherry. | Virology 502:133-143.
- 2016 Use of RNA-seq to identify cardiac genes and gene pathways differentially expressed between dogs with and without dilated cardiomyopathy.Friedenberg SG, Chdid L, Keene B, Sherry B, Motsinger-Reif A, Meurs KM. | Am J Vet Res 2016 Jul; 77(7):693-9.
- 2015. Generating primary cultures of murine cardiac myocytes and cardiac fibroblasts to study viral myocarditis.Sherry B | In G.R. Skuse and M.C. Ferran (ed.), Cardiomyocytes, Humana Press.
- 2014. Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs.Bogerd, H., R. Skalsky, E. Kennedy, Y. Furuse, A. Whisnant, O. Flores, K. Schultz, N. Putnam, N. Barrows, B. Sherry, F. Scholle, M. Garcia-Blanco, D. Griffin, and B. Cullen. | Journal of Virology, 88(14):8065-8076.
- 2014. An ITAM in a Nonenveloped Virus Regulates Activation of NF-κB, Induction of Beta Interferon, and Viral Spread.Stebbing, R.E., S.C. Irvin, E.E. Rivera-Serrano, K.W. Boehme, M. Ikizler, J.A. Yoder, T.S. Dermody, and B. Sherry. | Journal of Virology, 88(5):2572-2583.
- 2013. OrthoreovirusesDermody, T.S., J. Parker, and B Sherry. | In D.M. Knipe and P.M. Howley (ed.), Fields Virology, 6th ed, Lippincott Williams & Wilkins.
- 2012. A Single Amino Acid Polymorphism in Reovirus Protein µ2 Determines Repression of Interferon Signaling and Modulates Myocarditis.Irvin, S.C., J. Zurney, L.S. Ooms, J.D. Chappell, T.S. Dermody, and B Sherry. | Journal of Virology, 86(4):2302-2311.
- 2010. Interferon regulatory factor-3 attenuates reovirus myocarditis and contributes to viral clearanceHolm, G.H., A.J. Pruijssers, L. Li, P. Danthi, B. Sherry,and T.S. Dermody | Journal of Virology 84(14):6900 6908
- 2010. Proteomic analysis reveals virus-specific Hsp25 modulation in cardiac myocytesLi, L., J.R. Sevinsky, M.D. Rowland, J.L. Bundy, J.L. Stephenson and B. Sherry | Journal of Proteome Research 9(5):2460-2471
- 2010. IFN-a expression and antiviral effects are subtype- and cell type-specific in the cardiac response to viral infectionLi, L. and B. Sherry | Virology 396:59-68