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Siddhartha “Sid” Thakur, BVSc, MVSc, PhD

Professor
Director of Global Health, CVM
Director of Global Health, NC State

Contact:

sthakur@ncsu.edu
Office: 919.513.0729
Lab: Thakur Molecular Epidemiology
Lab Phone: 919.513.0729

Publications

View online at PubMed

Dr. Siddhartha “Sid” Thakur is a Professor in the College of Veterinary Medicine at North Carolina State University. He is the Director of Global Health program at both the College of Veterinary Medicine and the NC State University. He was the Associate Director at the Comparative Medicine Institute and led the Emerging and Infectious Diseases Research program. He received his Degree in Veterinary Medicine and Master of Veterinary Public Health from India. He earned his Ph.D. in Population Medicine at the College of Veterinary Medicine, NC State. Before joining the faculty at NC State University, Dr. Thakur was an Oakridge Research Fellow at Center for Veterinary Medicine, FDA, Maryland. He espouses the concepts of “One Health” and seeks to understand how antimicrobial resistance develops in “superbugs” that affect animal and human health. He has won numerous awards including the Larry Beuchat Young Researcher Award by the International Association for Food and the Outstanding Global Engagement award by NC State. He is currently an NC State Chancellor faculty scholar. Dr. Thakur has authored or co-authored 45 peer-reviewed publications and edited two books.
Affiliations
American Society for Microbiology
International Association for Food Protection
Duke One Health, https://sites.globalhealth.duke.edu/dukeonehealth/
Certifications
Oakridge Research Associated Universities Postdoctoral Fellow at Center for Veterinary Medicine, Food and Drug Administration, Laurel, Maryland, 20708. 2005-2007.
Doctor of Philosophy in Population Medicine, College of Veterinary Medicine, NC State University, Raleigh, North Carolina, 27606. 2002-2005.
Master of Veterinary Science in Veterinary Public Health, Indian Veterinary Research Institute, Izatnagar, India. 1998-2000.
Bachelor of Veterinary Science and Animal Husbandry, Gobind Ballabh Pant University of Agriculture and Technology, Udham Singh Nagar, India. 1993-1998.
Global Health, Infectious Diseases
Thakur Molecular Epidemiology Laboratory Mission: To improve food animal and human health by reducing the burden of bacterial food borne pathogens

Food borne diseases are increasingly recognized as a major public health problem both nationally as well as globally. Despite major advances and improvements in hygiene, quality of food, water, sanitation and detection of food borne pathogens, food borne diseases remain one of the leading public health concerns. There is tremendous economic burden of treating animals and human patients affected by antimicrobial resistant pathogens and critical knowledge gaps exist in the complex chain of events that leads to dissemination and persistence of these bacterial pathogens. There is no clear consensus on the significance of ecological and management factors in the dissemination of such antimicrobial resistant strains in humans. In addition, characterizing the pathogen to specific strain level is time consuming.

Research in our lab is focused on understanding the molecular epidemiology of important multidrug resistant (MDR) food borne pathogens at the pre-harvest and post-harvest food safety levels. The Thakur laboratory represents the state of North Carolina in two national surveillance systems, including the National Antimicrobial Resistance Monitoring system (NARMS) and the FDA whole genome sequencing GenomeTrakr program. Our specific goal is to determine the dynamics of Salmonella, Campylobacter, Shiga toxin producing Escherichia coli and Clostridium in food animals, retail meat, humans and the environment. With this information, we plan to achieve our long term goal of reducing the burden of infections caused by bacterial pathogens in food animals and humans by:

Determining the risk factors and understanding the dissemination of antimicrobial resistant strains in animals, humans and their environment,
Characterizing and elucidating the mechanisms of antimicrobial resistance at the molecular level,
Understanding the genotypic diversity and population dynamics of these bacterial populations through phylogenetic analysis,
Developing diagnostic methods that will aid in the rapid identification and characterization of bacterial pathogens and,
Conveying the results of these studies to the stakeholders and developing new curricula aimed at providing education and training of veterinary, animal and food science students.