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Dr. Siddhartha “Sid” Thakur is a Professor in the College of Veterinary Medicine at North Carolina State University. He is the Director of Global Health program at both the College of Veterinary Medicine and the NC State University. He was the Associate Director at the Comparative Medicine Institute and led the Emerging and Infectious Diseases Research program. He received his Degree in Veterinary Medicine and Master of Veterinary Public Health from India. He earned his Ph.D. in Population Medicine at the College of Veterinary Medicine, NC State. Before joining the faculty at NC State University, Dr. Thakur was an Oakridge Research Fellow at Center for Veterinary Medicine, FDA, Maryland. He espouses the concepts of “One Health” and seeks to understand how antimicrobial resistance develops in “superbugs” that affect animal and human health. He has won numerous awards including the Larry Beuchat Young Researcher Award by the International Association for Food and the Outstanding Global Engagement award by NC State. He is currently an NC State Chancellor faculty scholar. Dr. Thakur has authored or co-authored 45 peer-reviewed publications and edited two books.
AffiliationsAmerican Society for Microbiology
International Association for Food Protection
Duke One Health, https://sites.globalhealth.duke.edu/dukeonehealth/
CertificationsOakridge Research Associated Universities Postdoctoral Fellow at Center for Veterinary Medicine, Food and Drug Administration, Laurel, Maryland, 20708. 2005-2007.
Doctor of Philosophy in Population Medicine, College of Veterinary Medicine, NC State University, Raleigh, North Carolina, 27606. 2002-2005.
Master of Veterinary Science in Veterinary Public Health, Indian Veterinary Research Institute, Izatnagar, India. 1998-2000.
Bachelor of Veterinary Science and Animal Husbandry, Gobind Ballabh Pant University of Agriculture and Technology, Udham Singh Nagar, India. 1993-1998.
Global Health, Infectious DiseasesThakur Molecular Epidemiology Laboratory Mission: To improve food animal and human health by reducing the burden of bacterial food borne pathogens
Food borne diseases are increasingly recognized as a major public health problem both nationally as well as globally. Despite major advances and improvements in hygiene, quality of food, water, sanitation and detection of food borne pathogens, food borne diseases remain one of the leading public health concerns. There is tremendous economic burden of treating animals and human patients affected by antimicrobial resistant pathogens and critical knowledge gaps exist in the complex chain of events that leads to dissemination and persistence of these bacterial pathogens. There is no clear consensus on the significance of ecological and management factors in the dissemination of such antimicrobial resistant strains in humans. In addition, characterizing the pathogen to specific strain level is time consuming.
Research in our lab is focused on understanding the molecular epidemiology of important multidrug resistant (MDR) food borne pathogens at the pre-harvest and post-harvest food safety levels. The Thakur laboratory represents the state of North Carolina in two national surveillance systems, including the National Antimicrobial Resistance Monitoring system (NARMS) and the FDA whole genome sequencing GenomeTrakr program. Our specific goal is to determine the dynamics of Salmonella, Campylobacter, Shiga toxin producing Escherichia coli and Clostridium in food animals, retail meat, humans and the environment. With this information, we plan to achieve our long term goal of reducing the burden of infections caused by bacterial pathogens in food animals and humans by:
Determining the risk factors and understanding the dissemination of antimicrobial resistant strains in animals, humans and their environment,
Characterizing and elucidating the mechanisms of antimicrobial resistance at the molecular level,
Understanding the genotypic diversity and population dynamics of these bacterial populations through phylogenetic analysis,
Developing diagnostic methods that will aid in the rapid identification and characterization of bacterial pathogens and,
Conveying the results of these studies to the stakeholders and developing new curricula aimed at providing education and training of veterinary, animal and food science students.
Thakur Launches International Group to Combat Antimicrobial Resistance
As bacteria worldwide continue to develop resistance to life-saving drugs, NC State College of Veterinary Medicine researchers are joining a new group of international scientists dedicated to finding new ways to fight back. The global partnership, co-led by Sid Thakur, director of global health at the CVM and NC State, is a collaboration between faculty
A New Discovery, An Unforgettable Research Experience
Valerie Nelson was just looking to see what it was like to work in a research lab. What she found will impact lives around the world. While taking part in the Veterinary Scholars Program last summer at the NC State College of Veterinary Medicine, Nelson made an unexpected discovery. She had never worked in a
Salmonella Resistant to Antibiotics of Last Resort Found in U.S.
Researchers from NC State Veterinary Medicine have found a gene that gives Salmonella resistance to antibiotics of last resort in a sample taken from a human patient in the U.S. The find is the first evidence that the gene mcr-3.1 has made its way into the U.S. from Asia. There are more than 2,500 known serotypes of Salmonella. In the
CVM Partners With Senegal Institute to Fight Infectious Disease
The NC State College of Veterinary Medicine’s global health program is partnering with the Institut Pasteur Dakar in Senegal to advance infectious disease research in West Africa. The CVM and IPD will support pilot research projects led by faculty from both institutions. The two institutions are also developing training programs for students and researchers on
CVM Awards First Certificate in Global Health
The NC State College of Veterinary Medicine awarded its inaugural certificate in global health to fourth-year student Lizabeth Rennecker, whose work included laying the foundation for groundbreaking infectious disease research in Uganda. Rennecker, who’s set to graduate with the Class of 2019 in May, is the first student to earn a certificate in global health
Salmonella, Gene Swapping and Antibiotic Resistance: Five Questions with Sid Thakur
Thakur compared the genomes of over 200 different strains of Salmonella, looking for genetic similarities across strains. He spoke with the Abstract about what this work can tell us, and how it may help to keep us and our food supply safe.
Five Questions with Dean Lunn: Launching the Global Health Program
NC State’s College of Veterinary Medicine is merging global health research with the existing education program to create a single Global Health program. By streamlining these efforts, the new program will unite the strengths of both research faculty and teaching faculty to increase the global impact of the college.
Sid Thakur Named NC State Veterinary Medicine’s Director of Global Health
Siddhartha “Sid” Thakur has been named NC State College of Veterinary Medicine’s director of global health, a key leadership position reflective of the CVM’s commitment to solving some of the world’s greatest health challenges facing animals, humans and the environment. The position, effective July 1, is part of the development of a formal global
Thakur Earns Grant for Antimicrobial Surveillance Partnerships in India
A new NC State College of Veterinary Medicine project to strengthen the global fight against antimicrobial resistance has received an Internationalized Seed Grant from the university. The project is from Siddhartha “Sid” Thakur, CVM associate professor of molecular epidemiology and associate director of the Emerging and Infectious Disease Program at the Comparative Medicine Institute. His
Making Global Health a Priority
NC State faculty research helps bolster the university’s academic reputation and solve global challenges. Sid Thakur seeks to address one of those challenges — infectious diseases — through his work in the College of Veterinary Medicine. Thakur, an associate professor in the Department of Population Health and Pathobiology and Associate Director at the Comparative Medicine
CVM Receives Funding to Continue GenomeTrakr Program
In just one year, the GenomeTrakr program at the NC State College of Veterinary Medicine has mapped the intricate genetic fingerprints of 700 strains of pathogenic bacteria. It’s just the beginning. A new grant from the National Institutes of Health and the United States Food and Drug Administration will fund the program at the CVM
To Surveil and Protect: The Fight Against Antimicrobial Resistance
In the thick of war it pays to know your enemy, and bacteria is an unrelenting, captivating foe. “How does something that you can’t see, that doesn’t have a brain, develop very sophisticated survival mechanisms almost immediately?” said Paula Cray, head of the department of population health and pathobiology at the NC State College of
Pass It On: Bacteria Can Spread Antibiotic Resistance Through Soil
When most people think about bacterial antibiotic resistance, they think about it occurring in bacteria found in people or animals. But the environment surrounding us is a huge bacterial reservoir, and antibiotic resistance can be passed between bacteria in the environment, including in the soil. Sid Thakur is an associate professor of population health and