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Profile

Siddhartha “Sid” Thakur, BVSc, MVSc, PhD

Professor
Director Global Health, CVM
Associate Director, Comparative Medicine Institute

Contact:

sthakur@ncsu.edu
Office: 919.513.0729
Lab: Thakur Molecular Epidemiology
Lab Phone: 919.513.0729

Publications

View online at PubMed

Dr. Siddhartha Thakur is an Associate Professor of Molecular Epidemiology in the College of Veterinary Medicine at NC State University. He is the Associate Director at the Comparative Medicine Institute where he leads the Emerging and Infectious Diseases Research program. He received his Veterinary Science degree and Master in Veterinary Public Health from India. He earned his Ph.D. in Population Medicine at the College of Veterinary Medicine, NC State University. Prior to joining the faculty at NC State University, he was an Oakridge Research Fellow at Center for Veterinary Medicine, FDA, Maryland. Dr. Thakur espouses the concepts of “One Health” and uses its principals to study the impact of interplay between animals, humans and their environment on the dissemination and persistence of antimicrobial resistant bacterial strains. He was awarded the Larry Beuchat Young Researcher Award by the International Association for Food Protection in 2012 and is a NC State Chancellor faculty scholar. Dr. Thakur has authored or co-authored 42 peer reviewed publications and edited an ASM book on Pre-Harvest Food safety. His lab consists of five PhD candidates, one Masters, three research technicians, visiting scientists, and multiple undergraduate students.
Affiliations
American Society for Microbiology
International Association for Food Protection
Certifications
Oakridge Research Associated Universities Postdoctoral Fellow at Center for Veterinary Medicine, Food and Drug Administration, Laurel, Maryland, 20708. 2005-2007.
Doctor of Philosophy in Population Medicine, College of Veterinary Medicine, NC State University, Raleigh, North Carolina, 27606. 2002-2005.
Master of Veterinary Science in Veterinary Public Health, Indian Veterinary Research Institute, Izatnagar, India. 1998-2000.
Bachelor of Veterinary Science and Animal Husbandry, Gobind Ballabh Pant University of Agriculture and Technology, Udham Singh Nagar, India. 1993-1998.
Infectious Diseases
Thakur Molecular Epidemiology Laboratory Mission: To improve food animal and human health by reducing the burden of bacterial food borne pathogens

Food borne diseases are increasingly recognized as a major public health problem both nationally as well as globally. Despite major advances and improvements in hygiene, quality of food, water, sanitation and detection of food borne pathogens, food borne diseases remain one of the leading public health concerns. There is tremendous economic burden of treating animals and human patients affected by antimicrobial resistant pathogens and critical knowledge gaps exist in the complex chain of events that leads to dissemination and persistence of these bacterial pathogens. There is no clear consensus on the significance of ecological and management factors in the dissemination of such antimicrobial resistant strains in humans. In addition, characterizing the pathogen to specific strain level is time consuming.

Research in our lab is focused on understanding the molecular epidemiology of important multidrug resistant (MDR) food borne pathogens at the pre-harvest and post-harvest food safety levels. The Thakur laboratory represents the state of North Carolina in two national surveillance systems, including the National Antimicrobial Resistance Monitoring system (NARMS) and the FDA whole genome sequencing GenomeTrakr program. Our specific goal is to determine the dynamics of Salmonella, Campylobacter, Shiga toxin producing Escherichia coli and Clostridium in food animals, retail meat, humans and the environment. With this information, we plan to achieve our long term goal of reducing the burden of infections caused by bacterial pathogens in food animals and humans by:

Determining the risk factors and understanding the dissemination of antimicrobial resistant strains in animals, humans and their environment,
Characterizing and elucidating the mechanisms of antimicrobial resistance at the molecular level,
Understanding the genotypic diversity and population dynamics of these bacterial populations through phylogenetic analysis,
Developing diagnostic methods that will aid in the rapid identification and characterization of bacterial pathogens and,
Conveying the results of these studies to the stakeholders and developing new curricula aimed at providing education and training of veterinary, animal and food science students.