Glenn Cruse PhD
Glenn Cruse completed his Ph.D. under the supervision of Professor Peter Bradding at Glenfield Hospital, The University of Leicester, UK in 2009. He then moved to the National Institutes of Health in Bethesda, Maryland in January 2010 to start a visiting postdoctoral fellowship in the Laboratory of Allergic Diseases, NIAID, under the supervision of Dr. Dean Metcalfe. In January 2015, Dr. Cruse was appointed as a Research Fellow in the same laboratory. Dr. Cruse joined the Department of Molecular Biomedical Sciences at NCSU in January 2016 as an Assistant Professor.
Dr. Cruse is a mast cell biologist that has authored and co-authored over 30 publications including articles in top journals such as the New England Journal of Medicine, Proceedings of the National Academy of Sciences USA and Immunity. The Cruse lab is interested in the role that mast cells play in allergic and inflammatory diseases and identifying novel therapeutics that target mast cells. Since mast cells act as sentinel cells that participate in both innate and acquired immunity, particularly at biological barriers, emphasis on diseases in tissues at the interface with the environment such as the lung, skin, gastrointestinal tract and even the neuro-immune axis are the main focus of the lab.
Member of the American Association of Immunologists
Member of the American Thoracic Society
Member of the American Academy of Asthma, Allergy & Immunology
2009 Ph.D. University of Leicester Medical School, Leicester, UK
Area(s) of Expertise
BIOLOGICAL BARRIERS, GENETICS, IMMUNOLOGY, PHARMACOLOGY
The Cruse lab is interested in molecular immunology with particular focus on basic and translational research on allergy and inflammation. The mast cell is a critical regulator of allergic inflammation and thus a central focus of research in our lab. We have recently identified a method to specifically target mast cells by modifying gene splicing to eliminate expression of the high affinity IgE receptor on the mast cell surface, resulting in mast cells that are unresponsive to allergens. In addition to developing this therapeutic approach, our research goals include identifying other novel therapeutic targets and developing more effective treatments of allergic diseases, which have an unmet clinical need.
The key to achieving these goals is better understanding of the molecular mechanisms that trigger and promote allergic inflammation. Studies on mechanisms of activation and phosphorylation of different receptors in immune cells, and determining how they differ in signal transduction and protein trafficking pathways that regulate cytoskeletal reorganization and ionic conductance are of particular interest.
- The exon-skipping oligonucleotide, KitStop, depletes tissue-resident mast cells in vivo to ameliorate anaphylaxis , FRONTIERS IN IMMUNOLOGY (2023)
- Identification of redundancy between human Fc epsilon RI beta and MS4A6A proteins points toward additional complex mechanisms for Fc epsilon RI trafficking and signaling , ALLERGY (2022)
- Regulation of Trafficking and Signaling of the High Affinity IgE Receptor by Fc epsilon RI beta and the Potential Impact of Fc epsilon RI beta Splicing in Allergic Inflammation , INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
- Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms , MOLECULAR THERAPY (2022)
- Dermal Extracellular Matrix-Derived Hydrogels as an In Vitro Substrate to Study Mast Cell Maturation , TISSUE ENGINEERING PART A (2021)
- Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness , JCI INSIGHT (2021)
- Mast Cell-Biomaterial Interactions and Tissue Repair , TISSUE ENGINEERING PART B-REVIEWS (2021)
- Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles , JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2020)
- Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch , CELL REPORTS (2020)
- The FcεRIβ homologue, MS4A4A, promotes FcεRI signal transduction and store-operated Ca2+ entry in human mast cells , Cellular Signalling (2020)
- Research Area of Emphasis: Biological Barriers
- CVM: Focus Area
- Focus Area: Food Animal
- Research Area of Emphasis: Genetics
- Research Area of Emphasis: Immunology
- Molecular Biomedical Sciences: MBS Faculty
- Molecular Biomedical Sciences: MBS Researchers
- CVM: Molecular Biomedical Sciences
- Research Area of Emphasis: Pharmacology
- CVM: Research Area of Emphasis