Nick Buchler

Bio

Dr. Nicolas Buchler joined NC State in July 2018 as a Chancellor’s Faculty Excellence Program cluster hire in Modeling the Living Embryo. His research is focused on understanding how the cell cycle interacts with metabolic rhythms, and how changes in these interactions lead to disease or new functions. The lab primarily works with early-diverging Fungi and yeasts, but they collaborate with others to study these same questions in other regulatory systems (e.g. circadian clocks) and organisms (e.g. animals and plants).

Dr. Buchler received a B.S. in Physics from the University of California at San Diego, before working on protein structure and evolution while obtaining a Ph.D. in Biophysics at the University of Michigan at Ann Arbor. During his post-doc, first at the University of California at San Diego and then at the Center for Studies in Physics & Biology at Rockefeller University, he combined mathematical modeling and experiments to understand how networks of genes sense and respond to multiple signals, store memories of past events, and schedule periodic events (e.g. cell cycle).

Area(s) of Expertise

I am a biophysicist and geneticist by training with expertise in biological oscillations (e.g., cell cycle, metabolic rhythms), fungal genomics and evolution, single-cell gene expression, and mathematical modeling of gene regulatory dynamics.

Publications

• Deep learning-driven imaging of cell division and cell growth across an entire eukaryotic life cycle , (2024)
• Diploid-dominant life cycles characterize the early evolution of Fungi , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)
• Gene expression noise accelerates the evolution of a biological oscillator , (2022)
• Competition for DNA binding between paralogous transcription factors determines their genomic occupancy and regulatory functions , GENOME RESEARCH (2021)
• Chytrid fungi. , Current biology : CB (2020)
• Genetic transformation of Spizellomyces punctatus, a resource for studying chytrid biology and evolutionary cell biology , eLife (2020)
• Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes , CELL REPORTS (2019)
• Epigenetic switching as a strategy for quick adaptation while attenuating biochemical noise , PLOS COMPUTATIONAL BIOLOGY (2019)
• Evolutionary innovation, fungal cell biology, and the lateral gene transfer of a viral KilA-N domain , CURRENT OPINION IN GENETICS & DEVELOPMENT (2019)
• Exact and efficient hybrid Monte Carlo algorithm for accelerated Bayesian inference of gene expression models from snapshots of single-cell transcripts , The Journal of Chemical Physics (2019)

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