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College of Veterinary Medicine

Intracellular Pathogens Research Lab

Lab Contact: ncstateiprl@ncsu.edu

Support our Research

Support the Bartonella/Vector Borne Disease Research Fund
Support Our Research

We Are Grateful to Our Current Sponsors

  • Bayer Animal Health
  • IDEXX Laboratories

Research Team

Principal Investigators

EB
Ed Breitschwerdt
Edward Breitschwerdt

Professor

RM
Ricardo Maggi
Ricardo Maggi

Research Professor

919-513-8007

Research Staff

CR
Cynthia Robveille
Cynthia Robveille

Asst Research Professor

919-515-7457
LB
Lily Bartone

Research Technician-Nonexempt

EK
Emily Kingston

Research Specialist

Graduate Students

CM
Charlotte Manvell

Graduate Student

JB
Janice Bush
Janice Bush

Graduate Student

CL
Chance Liedig

Graduate Student

Publications

  1. Lashnits E, Thatcher B, Carruth A, Mestek A, Buch J, Beall M, Neupane P, Chandrashekar R, Breitschwerdt EB. Bartonella spp. seroepidemiology and associations with clinicopathologic findings in dogs in the United States. J Vet Intern Med. 2022;36(1):116-125. doi: 10.1111/jvim.16311.
  2. Maggi RG, Halls V, Krämer F, Lappin M, Pennisi MG, Peregrine AS, Roura X, Schunack B, Scorza V, Tasker S, Baneth G, Bourdeau P, Bowman DD, Breitschwerdt EB, Capelli G, Cardoso L, Dantas-Torres F, Dobler G, Ferrer L, Gradoni L, Irwin P, Jongejan F, Kempf VAJ, Kohn B, Little S, Madder M, Maia C, Marcondes M, Miró G, Naucke T, Oliva G, Otranto D, Penzhorn BL, Pfeffer M, Sainz Á, Shin S, Solano-Gallego L, Straubinger RK, Traub R, Wright I. 2022. Vector-borne and other pathogens of potential relevance disseminated by relocated cats. Parasit Vectors. 2022;15(1):415. doi: 10.1186/s13071-022-05553-8.
  3. Hui, J, Ryan K, Rademacher N, Neupane P, Breitschwerdt E. Osteomyelitis associated with Bartonella henselae in a cat. Feline Med Surg Open Reports 2022:8;1-5. doi:20551169221124910.
  4. Maggi R, Breitschwerdt EB, Qurollo B, Miller JC.Pathogens. Development of a Multiplex Droplet Digital PCR Assay for the Detection of Babesia, Bartonella, and Borrelia Species Pathogens 2021;10:1462. doi: 10.3390/pathogens10111462
  5. Lashnits, E, Neupane P, Bradley JM, Richardson T, Maggi RG, Breitschwerdt EB. Comparison of serological and molecular assays for Bartonella species in dogs with hemangiosarcoma. Pathogens. 2021;10:794.
  6. Neupane P, Sindhura S, Balakrishnan N, Marr H, Wilson J, Maggi R, Birkenheuer A, Lappin M, Chomel B, Brietschwerdt EB. Validation of Bartonella henselae Western immunoblotting for serodiagnosis of bartonellosis in dogs. J Clin Microbiol 2020;58:e01335-19.
  7. Lashnits E, Neupane P, Bradley JM, Richardson T, Thomas R, Linder KE, Breen M, Maggi RG, Breitschwerdt EB. Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma. PLoS One 2020;15(1).
  8. Lashnits E, Neupane P, Maggi R. Linder K, Bradley J, Balakrishnan N, Southern B. McKeon G, Ramasswamy C, Breitschwerdt EB. Detection of Bartonella spp. in dogs after infection with Rickettsia rickettsii. J Vet Int Med 2020;34:145-159.
  9. Lashnits E, Dawson DE, Breitschwerdt E, Lanzas C. Ecological and Socioeconomic Factors Associated with Bartonella henselae Exposure in Dogs Tested for Vector-Borne Diseases in North Carolina. Vector Borne Zoonotic Dis 2019;19:582-595.
  10. Southern SL, Neupane N, Ericson ME, Dencklau JC, Linder KE, Bradley JM, McKeon, GP, Long CT, Breitschwerdt EB. Bartonella henselae in a dog with ear tip vasculitis. Vet Derm 2018; 29:537-e180.
  1. Ericson ME, Breitschwerdt EB, Reicherter P, Maxwell C, Maggi RG, Melvin RG, Maluki AH, Bradley JM, Miller JC, Simmons GE Jr, Dencklau J, Joppru K, Peterson J, Bae W, Scanlon J, Bemis LT. Bartonella henselae Detected in Malignant Melanoma, a Preliminary Study. Pathogens. 2021;10:326.
  2. Lashnits E, Maggi R, Jarskog LF, Bradley J, Breitschwerdt EB, Frohlich F. Schizophrenia and Bartonella spp. infection: a pilot case-control study. Vector Borne Zoonotic Dis. 2021;21:413-421.
  3. Breitschwerdt EB, Bradley JM, Maggi RG, Lashnits E, Reicherter P. Bartonella Associated Cutaneous Lesions (BACL) cutaneous lesions in people with neuropsychiatric symptoms. Pathogens 2020;9:1023.
  4. Maggi RG, Richardson T, Breitschwerdt EB, Miller JC. Development and validation of a droplet digital PCR assay for the detection and quantification of Bartonella spp. within human clinical samples. J Microbiol Methods 2020;176:106022.
  5. Portillo A, Maggi R, Oteo JA, Bradley J, García-Álvarez L, San-Martín M, Roura X, Breitschwerdt E. Bartonella spp. Prevalence (Serology, Culture, and PCR) in Sanitary Workers in La Rioja Spain. Pathogens. 2020;9(3).
  6. Breitschwerdt EB, Maggi RG, Quach C, Bradley JM. Bartonella spp. Bloodstream Infection in a Canadian Family. Vector Borne Zoonotic Dis. 2019;19:234-241.
  7. Breitschwerdt EB, Greenberg R, Maggi RG, Lews A, Bradley JM.  Bartonella henselae infection in a boy with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). Journal of Nervous System Disease. 2019;11:1-8.
  8. Breitschwerdt EB, Maggi RG. Bartonella quintana and Bartonella vinsonii subsp. vinsonii bloodstream infection in a girl from North Carolina, USA. Med Microbiol Immunol 2019;28:101-107.
  9. Mozayeni BR, Maggi RG, Bradley JM, Breitschwerdt EB. Rheumatological presentation of Bartonella koehlerae and Bartonella henselae bacteremias: A case report. Medicine (Baltimore). 2018;97:e0465.
  10. Oteo JA, Maggi R, Portillo A, Cherry N, Bradley J, Garcia-Alvarez L, San-Marin M, Breitschwerdt EB. Prevalence of Bartonella spp. by culture, PCR and serology in veterinary professionals from Spain. Parasit Vectors. 2017;10:e553.
  1. André MR, Neupane P, Lappin M, Herrin B, Smith V, Williams TI, Collins L, Bai H, Jorge GL, Balbuena TS, Bradley J, Maggi RG, Breitschwerdt EB. Using proteomic approaches to unravel the response of Ctenocephalides felis felis to blood feeding and infection with Bartonella henselae. Front Cell Infect Microbiol. 2022 Jan 28;12:828082. doi: 10.3389/fcimb.2022.828082.
  2. Manvell C, Berman H, Callahan B, Breitschwerdt E, Swain W, Ferris K, Maggi R, Lashnits E. Identification of microbial taxa present in Ctenocephalides felis (cat flea) reveals widespread co-infection and associations with vector phylogeny. Parasit Vectors 2022;15:398. doi:10.1186/s13071-022-05487-1
  3. Maggi RG, Toliver M, Richardson T, Mather TN, Breitschwerdt EB,. Regional prevalences of Borrelia burgdorferi, Borrelia bissettiae, and Bartonella henselae in Ixodes affinis, Ixodes pacificus and Ixodes scapularis in the USA Ticks and Tick borne Diseases. 2019;10:360-364.