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Anthony Blikslager, DVM, PhD, DACVS

Professor, Equine Surgery & Gastroenterology

Contact:

anthony_blikslager@ncsu.edu
Office: 919.513.7725
Lab: Gastrointestinal Physiology
Lab Phone: 919.513.7725

Dr. Blikslager received his DVM from the Virginia-Maryland Regional College of Veterinary Medicine in 1989, and his PhD in Gastrointestinal Physiology from NC State University in 1997. He is a former head of the Department of Clinical Sciences at the NC State College of Veterinary Medicine. Dr. Blikslager has received numerous honors including the Applied Equine Research Award from the World Equestrian Veterinary Association, the Pfizer Award for Excellence in Research from the NC State College of Veterinary Medicine, and was inducted as a Fellow of the American Gastroenterological Association.
Certifications
Diplomate, American College of Veterinary Surgeons
Biological Barriers, Gastroenterology
Gastrointestinal Physiology, studying mechanisms responsible for maintenance and restoration of the intestinal barrier, with the ultimate objective of pharmacologically restoring the mucosal barrier in patients suffering from diseases associated with increased intestinal permeability. Restoring the intestinal barrier would be of particular significance in patients suffering from diseases such as intestinal ischemia/reperfusion injury, inflammatory bowel diseases, and gastric ulcer disease because of the potential medical complications associated with these diseases.

CLINICAL STUDIES
  • (2016) The key to translational discovery in digestive disease.Ziegler A, Gonzalez LM, Blikslager AT. |
  • (2015) Porcine models of digestive disease: the future of large animal translational research. Gonzalez LM, Moeser AJ, Blikslager AT. | Translational Research 2015;166(1)12-27. PMID:25655839.
  • (2015) Characterization of Discrete Equine Intestinal Epithelial Cell Lineages.Gonzalez LM, Kinnin LS, Blikslager AT. | Am J Vet Res 2015;76(4)358-66. PMID:25815577
  • (2015) Animal models of ischemia-reperfusion induced intestinal injury: progress and promise for translational research.Gonzalez LM, Moeser AJ, Blikslager AT. | Am J Physiol Gastrointest Liver Physiol 2015;308(2)G63-75. PMID:25414098.
  • (2015) Operative Factors Associated with Short-term Survival in Horses with Large Colon Volvulus: 47 cases from 2006 to 2013.Gonzalez LM, Fogle CF, Baker WT, Hughes FE, Law JM, Motsinger-Reif AA, Blikslager AT. | Equine Vet J 2015;47(3)279-84. PMID:24735170.
  • Validation of a photogrammetric technique for computing equine hoof volume.Labens R, Redding WR, Desai KK, Vom Orde K, Mansmann RA, Blikslager AT. | Vet J. 2013 197:625-30
  • Return to use and performance following exploratory celiotomy for colic in horses: 195 cases (2003-2010).Davis W, Fogle CA, Gerard MP, Levine JF, Blikslager AT. | Equine Vet J 2013:45:224-28. Featured at the AAEP Kester News Hour, 2013
  • Gastro protective properties of the novel prostone SPI-8811 against acid-injured porcine mucosa.Nighot M, Moeser A, Ueno R, Blikslager AT. | World J Gastroenterol 2012;18:4684-92.
  • Dietary long-chain PUFA enhance acute repair of ischemia-injured intestine of suckling pigs.Jacobi SK, Moeser AJ, Corl BA, Harrell RJ, Blikslager AT, Odle J | J Nutr 2012;142:1266-71
  • Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors.Cuppoletti J, Blikslager AT, Chakrabarti J, Nighot PK, Malinowska DH. | BMC Pharmacol 2012;12:1-12
  • Effect of a zinc l-carnosine compound on acid-induced injury in canine gastric mucosa ex vivo.Hill TL, Blikslager AT. | Am J Vet Res 2012;73:659-63.
  • Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infection.Meyerhoff RR, Nighot PK, Ali RA, Blikslager AT, Koci MD. | Comp Immunol Microbiol Infect Dis 2012;35:63-9
  • Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludin.Nighot PK, Blikslager AT. | Am J Physiol Cell Physiol 2012;302:C178-87.
  • Distribution of enrofloxacin and its active metabolite, using an in vivo ultrafiltration sampling technique after the injection of enrofloxacin to pigs.Messenger KM, Papich MG, Blikslager AT. | J Vet Pharmacol Ther 2012;35:452-9
  • The effects of a novel anti-inflammatory compound (AHI-805) on cyclooxygenase enzymes and the recovery of ischaemia injured equine jejunum ex vivo.Marshall JF, Bhatnagar AS, Bowman SG, Morris NN, Skorich DA, Redding CD, Blikslager AT. | Equine Vet J 2011;43 Suppl 39:106-11
  • Ultrastructural changes in the equine colonic mucosa after ischaemia and reperfusion.Grösche A, Morton AJ, Graham AS, Sanchez LC, Blikslager AT, Polyak MM, Freeman DE | Equine Vet J 2011;43 Suppl 39:8-15
  • Evaluation of the cyclooxygenase selectivity of robenacoxib and its effect on recovery of ischaemia-injured jejunal mucosa in horses.Marshall JF, Bhatnagar AS, Bowman SG, Howard CM, Morris NN, Skorich DA, Redding CD, Blikslager AT. | Am J Vet Res 2011;72:226-32. Featured at the AAEP Kester News Hour, 2011
  • Primary gastric impaction in horses: A retrospective study of 20 cases (2005-2008).Vainio KM, Sykes BW. Blikslager AT. | Equine Vet Educ 2011;23:186-90.
  • The pharmacokinetics and in vitro cyclooxygenase selectivity of deracoxib in horses.Davis JL, Marshall JF, Papich MG, Blikslager AT, Campbell NB. | J Vet Pharmacol Ther 2011;34:12-16
  • Pharmacokinetics and pharmacodynamics of three formulations of firocoxib in healthy horses.Holland B, Fogle C, Blikslager AT, Curling A, Barlow BM, Schirmer J, Davis JL. | J Vet Pharmacol Ther 2014, in press
  • Operative Factors Associated with Short-Term Outcome in Horses with Large Colon Volvulus: 47 cases from 2006 to 2013,Gonzalez LM, Fogle CA, Baker T, Hughes F, Law M, Blikslager AT. | Equine Vet J 2014 [Epub ahead of print]
  • The effect of tramadol and indomethacin co-administration on gastric barrier function in dogs.Hill, T, Lascelles BD, Law M, Blikslager AT. | J Vet Intern Med, 2014, in press
  • Chloride channel ClC-2 is a key factor in the development of DSS-Induced murine colitis.Nighot P, Young K, Nighot M, Sung EJ, Maharshak N, Plevy SE, Ma T, Blikslager AT. | Inf Bowel Dis 2013;19:2867-77
  • Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets.Jacobi SK, Moeser AJ, Blikslager AT, Rhoads JM, Corl BA, Harrell RJ, Odle J. | World J Gastroenterol 2013;19:5094-102.
  • Precision of a photogrammetric method to perform 3D wound measurements compared to standard 2D photographic techniques in the horse.Labens R, Blikslager AT. | Equine Vet J 2013;45:41-6
  • Pharmacokinetics and pharmacodynamics of three formulations of firocoxib in healthy horses.Holland B, Fogle C, Blikslager AT, Curling A, Barlow BM, Schirmer J, Davis JL. | J Vet Pharmacol Ther 2014, in press
  • Operative Factors Associated with Short-Term Outcome in Horses with Large Colon Volvulus: 47 cases from 2006 to 2013,Gonzalez LM, Fogle CA, Baker T, Hughes F, Law M, Blikslager AT. | Equine Vet J 2014 [Epub ahead of print]
  • The effect of tramadol and indomethacin co-administration on gastric barrier function in dogs.Hill, T, Lascelles BD, Law M, Blikslager AT. | J Vet Intern Med, 2014, in press
  • Chloride channel ClC-2 is a key factor in the development of DSS-Induced murine colitis.Nighot P, Young K, Nighot M, Sung EJ, Maharshak N, Plevy SE, Ma T, Blikslager AT. | Inf Bowel Dis 2013;19:2867-77
  • Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets.Jacobi SK, Moeser AJ, Blikslager AT, Rhoads JM, Corl BA, Harrell RJ, Odle J. | World J Gastroenterol 2013;19:5094-102.
  • Precision of a photogrammetric method to perform 3D wound measurements compared to standard 2D photographic techniques in the horse.Labens R, Blikslager AT. | Equine Vet J 2013;45:41-6
  • Validation of a photogrammetric technique for computing equine hoof volume.Labens R, Redding WR, Desai KK, Vom Orde K, Mansmann RA, Blikslager AT. | Vet J. 2013 197:625-30
  • Return to use and performance following exploratory celiotomy for colic in horses: 195 cases (2003-2010).Davis W, Fogle CA, Gerard MP, Levine JF, Blikslager AT. | Equine Vet J 2013:45:224-28. Featured at the AAEP Kester News Hour, 2013
  • Gastro protective properties of the novel prostone SPI-8811 against acid-injured porcine mucosa.Nighot M, Moeser A, Ueno R, Blikslager AT. | World J Gastroenterol 2012;18:4684-92.
  • Dietary long-chain PUFA enhance acute repair of ischemia-injured intestine of suckling pigs.Jacobi SK, Moeser AJ, Corl BA, Harrell RJ, Blikslager AT, Odle J | J Nutr 2012;142:1266-71
  • Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors.Cuppoletti J, Blikslager AT, Chakrabarti J, Nighot PK, Malinowska DH. | BMC Pharmacol 2012;12:1-12
  • Effect of a zinc l-carnosine compound on acid-induced injury in canine gastric mucosa ex vivo.Hill TL, Blikslager AT. | Am J Vet Res 2012;73:659-63.
  • Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infection.Meyerhoff RR, Nighot PK, Ali RA, Blikslager AT, Koci MD. | Comp Immunol Microbiol Infect Dis 2012;35:63-9
  • Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludin.Nighot PK, Blikslager AT. | Am J Physiol Cell Physiol 2012;302:C178-87.
  • Distribution of enrofloxacin and its active metabolite, using an in vivo ultrafiltration sampling technique after the injection of enrofloxacin to pigs.Messenger KM, Papich MG, Blikslager AT. | J Vet Pharmacol Ther 2012;35:452-9
  • The effects of a novel anti-inflammatory compound (AHI-805) on cyclooxygenase enzymes and the recovery of ischaemia injured equine jejunum ex vivo.Marshall JF, Bhatnagar AS, Bowman SG, Morris NN, Skorich DA, Redding CD, Blikslager AT. | Equine Vet J 2011;43 Suppl 39:106-11
  • Ultrastructural changes in the equine colonic mucosa after ischaemia and reperfusion. | Equine Vet J 2011;43 Suppl 39:8-15
  • Evaluation of the cyclooxygenase selectivity of robenacoxib and its effect on recovery of ischaemia-injured jejunal mucosa in horses.Marshall JF, Bhatnagar AS, Bowman SG, Howard CM, Morris NN, Skorich DA, Redding CD, Blikslager AT. | Am J Vet Res 2011;72:226-32. Featured at the AAEP Kester News Hour, 2011
  • Primary gastric impaction in horses: A retrospective study of 20 cases (2005-2008).Vainio KM, Sykes BW. Blikslager AT. | Equine Vet Educ 2011;23:186-90.
  • The pharmacokinetics and in vitro cyclooxygenase selectivity of deracoxib in horses.Davis JL, Marshall JF, Papich MG, Blikslager AT, Campbell NB. | J Vet Pharmacol Ther 2011;34:12-16
  • (2013) Development of a porcine model to study stem cell driven regeneration of the intestinal epithelium. Gonzalez LM, Williamson I, Piedrahita JA, Blikslager AT, Magness ST. | PLoS ONE 2013;8(6):e66465. PMID:23840480.
  • (2013) Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration.Gonzalez LM, Williamson I, Piedrahita JA, Blikslager AT, Magness ST. | PLoS One 2013 Jun 28;8(6):e66465. doi: 10.1371/journal.pone.0066465. Print 2013.
  • (2013) Ex vivo effect of gold nanoparticles on porcine synovial membrane.Labens R, Lascelles BD, Charlton AN, Ferrero NR, Van Wettere AJ, Xia XR, Blikslager AT. | Tissue Barriers April/May/June 2013. eLocation ID: e24314
  • (2012) Misoprostol Protects Gastric Barrier Function after Acid Injury in a Novel Ex Vivo Canine ModelHill T, Young K, Lascelles BDX, Blikslager AT | Poster presentation at Digestive Diseases Week 19-22 May 2012
  • (2010) Evaluation of the Relationship between Gastrointestinal Injury and Cyclooxygenase (COX) Expression in Clinically Normal DogsWooten J, Lascelles BDX, Cook V, Law M, Blikslager AT. | American Journal of Veterinary Research 2010;71(6):630-635
  • (2009) Effect of non-steroidal anti-inflammatory drugs with varying cyclooxygenase (COX)-2 selectivity on COX protein and prostanoid concentrations in canine pyloric and duodenal mucosaWooten J, Blikslager AT, Marks S, Law M, Graeber E, Lascelles BDX | American Journal of Veterinary Research 2009;70:1243-1249
  • (2008) Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugsWooten JG, Blikslager AT, Ryan KA, Marks SL, Law M, Lascelles BDX | American Journal of Veterinary Research 2008;69(4):457-464
  • (2005) Evaluation of 29 cases of duodenal perforation in dogs receiving a selective COX-2 inhibitorLascelles BDX, Blikslager A, Fox S and Reece D | Journal of American Veterinary Medical Association (2005) 227:1112-1117