Learn more about Dr. Gonzalez:
Biological Barriers, Gastroenterology, Global HealthIntestinal disease is severely debilitating to both veterinary and human patients. In horses, colic is the leading known cause of death. Additionally, gastrointestinal diseases affect approximately 60 to 70 million Americans annually. One of the most dangerous forms of intestinal disease that afflicts both humans and animals is intestinal ischemia and reperfusion injury, which result in a lack of blood flow to the intestine.
In the face of no new therapies for treatment of intestinal ischemia in
decades, intestinal stem cells have been heralded as the greatest
potential therapeutic because of their tremendous capacity for proliferation and mucosal repair. Intensive study is underway to understand and harness the therapeutic potential of intestinal stem cells. NC State is leading the way in the field of large animal intestinal stem cells and novel stem cell-driven structures called enteroids, or “mini guts.”
- (2018) Veterinary Medical Students' Motivations for Exercise.Royal KD, Hunt SA, Gonzalez LM, Lewbart GA, Bailey KM. | J Vet Med Educ 2018 Jan 18:1-7.
- (2016) Large Animal Models: The Key to Translational Discovery in Digestive Disease Research.Ziegler A, Gonzalez LM, Blikslager AT. | Cell Mol Gastroenterol Hepatol 2016 Nov;2(6):716-724.
- (2016) Book Chapter: Intestinal Stem Cells.Gonzalez LM. | In: Blikslager AT, White NA, Moore JN, Mair TS, Eds., Equine Acute Abdomen, 3rd Edition. Wiley & Sons, Inc. Hoboken, NJ, 2016
- (2016) Book Chapter: Intestinal Viability.Gonzalez LM. | In: Blikslager AT, White NA, Moore JN, Mair TS, Eds., Equine Acute Abdomen, 3rd Edition. Wiley & Sons, Inc. Hoboken, NJ, 2016
- (2016) An evaluation of the psychometric properties of an advising survey for medical and professional program students.Royal KD, Gonzalez LM. | Journal of Educational Developmental Psychology 2016;6(1):195-203.
- (2015) The mother of a gut cell: Intestinal epithelial stem cells. Gonzalez LM, | Equine Vet Educ. Invited editorial 2015;27(11)559-560.
- (2015) Porcine models of digestive disease: the future of large animal translational research. Gonzalez LM, Moeser AJ, Blikslager AT. | Translational Research 2015;166(1)12-27. PMID:25655839. Epub 2015 Jan 13.
- (2015) Characterization of Discrete Equine Intestinal Epithelial Cell Lineages.Gonzalez LM, Kinnin LS, Blikslager AT. | Am J Vet Res 2015;76(4)358-66. PMID:25815577
- (2015) Animal models of ischemia-reperfusion induced intestinal injury: progress and promise for translational research.Gonzalez LM, Moeser AJ, Blikslager AT. | Am J Physiol Gastrointest Liver Physiol 2015;308(2)G63-75. PMID:25414098. Epub 2014 Nov 20.
- (2015) Operative Factors Associated with Short-term Outcome in Horses with Large Colon Volvulus: 47 cases from 2006 to 2013.Gonzalez LM, Fogle CF, Baker WT, Hughes FE, Law JM, Motsinger-Reif AA, Blikslager AT. | Equine Vet J 2015;47(3)279-84. PMID:24735170. Epub 2014 May 29.
- (2013) Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration. Gonzalez LM, Williamson I, Piedrahita JA, Blikslager AT, Magness ST. | PLoS ONE 2013;8(6):e66465. PMID:23840480. Print 2013.
- (2010) Magnetic resonance imaging of metacarpo(tarso) phalangeal region.Gonzalez LM, Schramme MC, Redding WR, Robertson ID, Thrall DE. | Vet Radiol Ultrasound 2010;51:404-414. PMID:20806872.
CVM Grad Student Wins National Veterinary Research Award
NC State College of Veterinary Medicine Ph.D. student Amy Stieler Stewart is the winner of the 2019 Boehringer Ingelheim Veterinary Graduate Award for her innovative research using stem cells to treat intestinal injury. Stewart received the honor during last weekend’s National Veterinary Scholars Symposium co-sponsored Boehringer Ingelheim, a pharmaceutical company specializing in human and animal
Call in the Reserves: Two Types of Stem Cells Repair Intestinal Injury
New research from NC State reveals your body’s “backup plan” – in the form of reserve stem cells – for recovering from severe intestinal injury due to lack of blood supply. The intestinal tract is one of the busiest organs in the human body. It’s also one of the most regenerative – the cells that line
Mucosal Environment of Older Pigs Helps Newborn Piglets with Intestinal Injury Recover
Intestinal ischemic injury occurs when blood flow to a portion of the intestine is cut off, resulting in the loss of epithelial cells that line intestinal walls. Once this barrier is damaged, intestinal contents can leak into the bloodstream, causing sepsis and often fatal infections...
Specialty Spotlight: Colic
NC State’s equine program provides expert care for colic at the country’s preeminent center for excellence in treatment. Our colic specialists, widely recognized experts in equine surgery and gastroenterology, work closely with clients to offer the most personalized care for each and every horse with colic. From highly successful surgical and non-surgical treatment approaches, to
Tiny Cellular Worlds, Big Medical Breakthrough
They’re called “mini guts,” and they are a leap forward in the study and prevention of devastating intestinal diseases in horses. Researchers at the NC State College of Veterinary Medicine have successfully isolated and recreated the innermost layer of a horse’s intestine using stem cells. All the intricate nooks and crannies of intestinal cells can