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Natasha Olby, Vet MB, PhD, MRCVS, DACVIM (Neurology)

The Dr. Kady M. Gjessing and Rahna M. Davidson Distinguished Chair in Gerontology, Professor Neurology and Neurosurgery

Contact:

njolby@ncsu.edu
Office: 919.513.8286
Lab: Canine Spinal Cord Injury
Lab Phone: 919.513.7235

Natasha Olby gained her veterinary degree from Cambridge University in the UK in 1991, and after a brief period spent in mixed general practice, returned to Cambridge to complete a PhD in spinal cord injury and a surgical training.

Following completion of her PhD and a post doctoral position, also focused on spinal cord injury, she moved to North Carolina State University to do a neurology/neurosurgery residency and she has stayed at NCSU as a faculty member since then.

Dr. Olby is the 2014 recipient of the Faculty Achievement Award from the American Association of Veterinary
Clinicians. The award is presented to an AAVC member who has achieved national recognition in academic or institutional practice, teaching, research, or in
another endeavor that advances veterinary medicine.

She is the author or co-author of more than 100 scientific publications, is the co-editor of both the British Small Animal Veterinary Association (BSAVA) Manual of Canine and Feline Neurology, and Advances in Veterinary Neurology, 2014. Vet Clinics of North America. Additionally, Dr. Olby authors book chapters in a variety of veterinary textbooks and manuals.

Natasha Olby is a professor of veterinary neurology and neurosurgery. She is board certified in the American College of Veterinary Internal Medicine Neurology Specialty and is a past president of the organization (2008-2011).
Certifications
Doctor of Philosophy (PhD), Neurosciences, University of Cambridge, UK, 1996
Veterinary degree (VetMB), University of Cambridge, 1991
Bachelor of Arts (BA), University of Cambridge, 1988
Genetics, Neurobiology
Treatment of spinal cord injury
Understanding the genetic basis of hereditary neurodegenerative diseases and brain neoplasia
Therapy of canine brain tumors
Veterinary Genetics Laboratory (Cardiology/Neurology)

Current Studies

Genetic Study on Cavalier King Charles Spaniels with and without Chiari-like Malformation and Syringomyelia

Ongoing Studies


Levine GJ (Co-PI), Olby NJ (co-PI), Meurs K, Levine J, Grossman R. Mapping of Chromosomal Loci Associated with Injury Severity and Locomotor Recovery Following Acute Spinal Cord Injury in the Dachshund dog. Funded by Mission Connect
Olby NJ (co-PI), Gunderson S (co-PI). Silencing the Canine SOD1 Gene in Dog Central Nervous System for Treatment of Degenerative Myelopathy. Funded by the Finding the Cure for DM Foundation

Completed Studies


Predictors of response to potassium channel blockade in chronically paralyzed dogs.

Predictors of response to potassium channel blockade in chronically paralyzed dogs. In a previous clinical trial, we showed that chronically paralyzed dogs have better stepping scores when treated with 4-aminopyridine, a drug that blocks potassium channels. However, we also reported that the response to this drug varied widely between individuals and the current study tried

The Effect of Post-Operative Rehabilitation on Recovery from Acute Thoracolumbar Intervertebral Disc Herniations

Recovery from spinal cord injury relies in part on the plasticity of the central nervous system. Plasticity is the ability of uninjured parts of the nervous system to take over the functions of parts that have been injured. This process can be enhanced by rehabilitation but the impact of rehabilitation programs in dogs recovering from

The effect of electromagnetic fields on postoperative pain and locomotor recovery in dogs with acute, severe thoracolumbar intervertebral disc extrusion: a randomized placebo-controlled, prospective clinical trial.

This study was sponsored by Assisi Animal Health. There is growing interest in the therapeutic potential of electromagnetic fields. Pulsed electromagnetic fields (PEMF) can have an effect at a cellular level, triggering pathways that result in reductions in inflammation and increases in growth factors. Human clinical trials show PEMF reduce pain following surgery and new

A Placebo-Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disc Herniation

Thirteen different centers participated in the trial across the US, and submitted their data to our research group. The dogs recruited had suffered the most severe grade of spinal cord injury due to...

Comparison of the effect of potassium channel antagonists and placebo on pelvic limb and bladder function in chronically paraparetic dogs – a blinded study funded by Neurometrix Inc

This project evaluated the effect of potassium channel blockade on stepping ability in dogs that were unable to walk. The premise for this study is that following severe spinal cord injury, some anatomically intact but...

CLINICAL STUDIES
  • (2018) The effect of electromagnetic fields on postoperative pain and locomotor recovery in dogs with acute, severe thoracolumbar intervertebral disc extrusion: a randomized placebo-controlled, prospective clinical trial.Zidan N, Fenn J, Griffith E, Early PJ, Mariani CL, Munana KR, Guevar J, Olby N. | J Neurotrauma 2018 Jan 8. doi: 10.1089/neu.2017.5485.
  • (2017) Questionnaire-based Analysis of Owner-reported Scratching and Pain Signs in Cavalier King Charles Spaniels Screened for Chiari-like Malformation and Syringomyelia.Sparks CR, Cerda-Gonzalez S, Griffith EH, Lascelles BDX, Olby NJ. | J Vet Intern Med 2017 Nov 4. doi: 10.1111/jvim.14856.
  • (2017) Magnetic resonance imaging features of dogs with incomplete recovery after acute, severe spinal cord injury.Lewis MJ, Cohen EB, Olby NJ. | Spinal Cord 2017 Oct 23. doi: 10.1038/s41393-017-0004-8.
  • (2017) The Frequency and Clinical Implications of Bacteriuria in Chronically Paralyzed Dogs.Rafatpanah Baigi S, Vaden S, Olby NJ. | J Vet Intern Med 2017 Nov;31(6):1790-1795. doi: 10.1111/jvim.14854. Epub 2017 Oct 14.
  • (2017) The Relationship between Lesion Severity Characterized by Diffusion Tensor Imaging and Motor Function in Chronic Canine Spinal Cord Injury.Lewis MJ, Yap PT, McCullough S, Olby NJ. | J Neurotrauma 2017 Nov 17. doi: 10.1089/neu.2017.5255.
  • (2017) Clinical Characteristics of Dogs with Progressive Myelomalacia Following Acute Intervertebral Disc Extrusion.Castel A, Olby NJ, Mariani CL, Muñana KR, Early PJ. | J Vet Intern Med 2017 Nov;31(6):1782-1789. doi: 10.1111/jvim.14829. Epub 2017 Sep 29.
  • (2017) Quantifying center of pressure variability in chondrodystrophoid dogs.Blau SR, Davis LM, Gorney AM, Dohse CS, Williams KD, Lim JH, Pfitzner WG, Laber E, Sawicki GS, Olby NJ. | Vet J 2017 Aug;226:26-31. doi: 10.1016/j.tvjl.2017.07.001. Epub 2017 Jul 20.
  • (2017) Development of a clinical spasticity scale for evaluation of dogs with chronic thoracolumbar spinal cord injury.Lewis MJ, Olby NJ. | Am J Vet Res 2017 Jul;78(7):854-861. doi: 10.2460/ajvr.78.7.854.
  • (2017) Genetics of Hereditary Ataxia in Scottish Terriers.Urkasemsin G, Nielsen DM, Singleton A, Arepalli S, Hernandez D, Agler C, Olby NJ. | J Vet Intern Med 2017 Jul;31(4):1132-1139. doi: 10.1111/jvim.14738. Epub 2017 May 29.
  • (2017) The Relationship between Trans-Lesional Conduction, Motor Neuron Pool Excitability, and Motor Function in Dogs with Incomplete Recovery from Severe Spinal Cord Injury.Lewis MJ, Howard JF Jr, Olby NJ. | J Neurotrauma 2017 Nov 1;34(21):2994-3002. doi: 10.1089/neu.2017.5012. Epub 2017 Jun 16.
  • (2017) Associations Between Anesthetic Variables and Functional Outcome in Dogs With Thoracolumbar Intervertebral Disk Extrusion Undergoing Decompressive Hemilaminectomy.Fenn J, Laber E, Williams K, Rousse CA, Early PJ, Mariani CL, Muñana KR, De Decker S, Volk HA, Olby NJ. | J Vet Intern Med 2017 May;31(3):814-824. doi: 10.1111/jvim.14677. Epub 2017 Mar 13.
  • (2017) Evaluation of gene expression and DNA copy number profiles of adipose tissue-derived stromal cells and consecutive neurosphere-like cells generated from dogs with naturally occurring spinal cord injury.Lim JH, Koh S, Thomas R, Breen M, Olby NJ. | Am J Vet Res 2017 Mar;78(3):371-380. doi: 10.2460/ajvr.78.3.371.
  • (2017) Targeting Translational Successes through CANSORT-SCI: Using Pet Dogs To Identify Effective Treatments for Spinal Cord Injury.Moore SA, Granger N, Olby NJ, Spitzbarth I, Jeffery ND, Tipold A, Nout-Lomas YS, da Costa RC, Stein VM, Noble-Haeusslein LJ, Blight AR, Grossman RG, Basso DM, Levine JM. | J Neurotrauma 2017 Jun 15;34(12):2007-2018. doi: 10.1089/neu.2016.4745. Epub 2017 Mar 22.
  • (2017) The effect of cranberry extract on the frequency of bacteriuria in dogs following acute thoracolumbar disc herniation: a randomized controlled clinical trial.Olby NJ, Vaden S, Williams K, Griffith E, Harris T, Mariani C, Munana K, Early P, Platt S, Boozer L, Giovanella C, Longshore R. | J Vet Intern Med, 2017 Jan;31(1):60-68. doi: 10.1111/jvim.14613. Epub 2016 Dec 3.
  • (2016) Mechanical and Thermal Sensory Testing in Normal Chondrodystrophoid Dogs and Dogs with Spinal Cord Injury caused by Thoracolumbar Intervertebral Disc HerniationsA.M. Gorney, S.R. Blau, C.S. Dohse, E.H. Griffith, K.D. Williams, J.-H. Lim, D. Knazovicky, B.D.X. Lascelles andN.J. Olby | Journal of Veterinary Internal Medicine 5 MAR 2016 DOI: 10.1111/jvim.13913
  • (2016) A Placebo-Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disk Herniation.Olby NJ, Muguet-Chanoit, Lim JH, Davidian M, Mariani CL, Freeman AC, Platt SR, Humphrey J, Kent M, Giovanella C, Longshore R, Early PJ, Muñana KR | Journal of Veterinary Internal Medicine 2016 Jan;30(1):206-14
  • (2016) Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs.Friedenberg SG, Buhrman G, Chdid L, Olby NJ, Olivry T, Guillaumin J, O'Toole T, Goggs R, Kennedy LJ, Rose RB, Meurs KM. | Immunogenetics 2016 Mar;68(3):205-17. doi: 10.1007/s00251-015-0894-6. Epub 2015 Dec 28.
  • (2016) Clinical characteristics of canine fibrocartilaginous embolic myelopathy (FCE): a systematic review of 393 cases (1973-2013).Bartholomew KA, Stover KE, Olby NJ, Moore SA. | Vet Rec 2016 Dec 24;179(25):650. doi: 10.1136/vr.103863. Epub 2016 Sep 28.
  • (2016) Generation of pure cultures of autologous Schwann cells by use of biopsy specimens of the dorsal cutaneous branches of the cervical nerves of young adult dogs.Lim JH, Olby NJ. | Am J Vet Res 2016 Oct;77(10):1166-74. doi: 10.2460/ajvr.77.10.1166.
  • (2016) Clinical and Diagnostic Imaging Features of Brain Herniation in Dogs and Cats.Lewis MJ, Olby NJ, Early PJ, Mariani CL, Muñana KR, Seiler GS, Griffith EH. | J Vet Intern Med 2016 Sep;30(5):1672-1680. doi: 10.1111/jvim.14526. Epub 2016 Sep 12.
  • (2016) Longitudinal Study of the Relationship among Craniocervical Morphology, Clinical Progression, and Syringomyelia in a Cohort of Cavalier King Charles Spaniels.Cerda-Gonzalez S, Olby NJ, Griffith EH. | J Vet Intern Med 2016 Jul;30(4):1090-8. doi: 10.1111/jvim.14362. Epub 2016 Jun 17.
  • (2016) Recovery of stepping and coordination in dogs following acute thoracolumbar intervertebral disc herniations.Rousse CA, Olby NJ, Williams K, Harris TL, Griffith EH, Mariani CL, Muñana KR, Early PJ. | Vet J 2016 Jul;213:59-63. doi: 10.1016/j.tvjl.2016.04.002. Epub 2016 Apr 8.
  • (2016) Acute change in neurological level following canine intervertebral disc herniation.Castel A, Olby NJ. | J Small Anim Pract 2016 Apr;57(4):220. doi: 10.1111/jsap.12445.
  • (2015) Dorsal compressive atlantoaxial bands and the craniocervical junction syndrome: association with clinical signs and syringomyelia in mature cavalier King Charles spaniels.Cerda-Gonzalez S, Olby NJ, Griffith EH. | J Vet Intern Med 2015 May-Jun;29(3):887-92. doi: 10.1111/jvim.12604.
  • (2015) Medullary position at the craniocervical junction in mature cavalier King Charles spaniels: relationship with neurologic signs and syringomyelia.Cerda-Gonzalez S, Olby NJ, Griffith EH. | J Vet Intern Med 2015 May-Jun;29(3):882-6. doi: 10.1111/jvim.12605. Epub 2015 Apr 30.
  • (2015) Histiocytic sarcoma with central nervous system involvement in dogs: 19 cases (2006-2012).Mariani CL, Jennings MK, Olby NJ, Borst LB, Brown JC Jr, Robertson ID, Seiler GS, MacKillop E. | J Vet Intern Med 2015 Mar-Apr;29(2):607-13. doi: 10.1111/jvim.12554. Epub 2015 Feb 25.
  • (2015) Clinical characteristics of Scottie Cramp in 31 cases.Urkasemsin G, Olby NJ. | J Small Anim Pract 2015 Apr;56(4):276-80. doi: 10.1111/jsap.12317. Epub 2015 Jan 20.
  • (2015) A rare homozygous MFSD8 single-base-pair deletion and frameshift in the whole genome sequence of a Chinese Crested dog with neuronal ceroid lipofuscinosis.Guo J, O'Brien DP, Mhlanga-Mutangadura T, Olby NJ, Taylor JF, Schnabel RD, Katz ML, Johnson GS. | BMC Vet Res 2015 Jan 3;10:960. doi: 10.1186/s12917-014-0181-z.
  • (2014) Advances in veterinary neurologyOlby NJ, Jeffery ND | Vet Clin North Am Small Anim Pract 2014 Nov;44(6):xi-xii. doi: 10.1016/j.cvsm.2014.08.001. Epub 2014 Sep 22
  • (2014) Gait scoring in dogs with thoracolumbar spinal cord injuries when walking on a treadmillOlby NJ, Lim JH, Babb K, Bach K, Domaracki C, Williams K, Griffith E, Harris T, Muguet-Chanoit A | BMC Vet Res 2014 Mar 5;10:58. doi: 10.1186/1746-6148-10-58
  • (2014) Potassium channel antagonists 4-aminopyridine and the T-butyl carbamate derivative of 4-aminopyridine improve hind limb function in chronically non-ambulatory dogs; a blinded, placebo-controlled trial.Lim JH, Muguet-Chanoit AC, Smith DT, Laber E, Olby NJ | PLoS One. 2014 Dec 31;9(12):e116139. doi: 10.1371/journal.pone.0116139. eCollection 2014
  • (2013) Intervertebral disk degeneration in dogs: consequences, diagnosis, treatment, and future directionsJeffery ND, Levine JM, Olby NJ, Stein VM | J Vet Intern Med 2013 Nov-Dec;27(6):1318-33. doi: 10.1111/jvim.12183. Epub 2013 Sep 6.
  • (2013) Alternating current electric fields of varying frequencies: effects on proliferation and differentiation of porcine neural progenitor cellsLim JH, McCullen SD, Piedrahita JA, Loboa EG, Olby NJ | Cell Reprogram 2013 Oct;15(5):405-12. doi: 10.1089/cell.2013.0001. Epub 2013 Aug 20
  • (2013) Long-term effect of cervical distraction and stabilization on neurological status and imaging findings in giant breed dogs with cervical stenotic myelopathyLewis M, Olby NJ, Sharp NJ, Early P | Vet Surg 2013 Aug;42(6):701-9. doi: 10.1111/j.1532-950X.2013.12034.x. Epub 2013 Jul 25
  • (2013) Assessment of cord dorsum potentials from caudal nerves in anesthetized clinically normal adult dogs without or during neuromuscular blockadeCampbell JO, Olby NJ, Hash JA, Lascelles BD | Am J Vet Res 2013 Apr;74(4):616-20. doi: 10.2460/ajvr.74.4.616
  • (2012) Isolation and characterization of neural progenitor cells from adult canine brainsLim JH, Koh S, Olby NJ, Piedrahita J, Mariani CL | Am J Vet Res 2012 Dec;73(12)
  • (2012) Growth requirements and chromosomal instability of induced pluripotent stem cells generated from adult canine fibroblastsKoh S, Thomas R, Tsai S, Bischoff S, Lim JH, Breen M, Olby NJ, Piedrahita JA | Stem Cells Dev 2013 Mar 15;22(6):951-63. doi: 10.1089/scd.2012.0393. Epub 2012 Nov 28
  • (2012) The cutaneous trunci muscle reflex: a predictor of recovery in dogs with acute thoracolumbar myelopathies caused by intervertebral disc extrusions.Muguet-Chanoit AC, Olby NJ, Lim J-H, Gallagher R, Niman Z, Dillard S, Campbell J, Early P, Mariani C, Munana KR, Freeman C, Platt SR, Kent M, Giovenella C, Longshore R | Vet Surg 2012 Feb;41(2):200-6. doi: 10.1111/j.1532-950X.2011.00921.x. Epub 2011 Dec 8.
  • (2012) Evaluation of levetiracetam as adjunctive treatment for refractory canine epilepsy: A randomized, placebo-controlled, cross-over trial.Muñana KR, Thomas WB, Inzana KD, Nettifee-Osborne JA, McLucas KJ, Olby NJ, Mariani CM, Early PJ. | Journal of Veterinary Internal Medicine 2012; 26:341-348.
  • (2011) The sensory field and repeatability of the cutaneous trunci muscle reflex in the dogMuguet-Chanoit AC, Olby NJ, Babb K, Lim J-H, Gallagher R, Niman Z, Dillard S, Campbell J | Vet Surg 2011 Oct;40(7):781-5. doi: 10.1111/j.1532-950X.2011.00888.x.
  • (2010) The pathogenesis and treatment of acute spinal cord injuries in dogsOlby N | Vet Clin North Am Small Anim Pract. 2010;40(5):791-807
  • (2010) Generation and characterization of neurospheres from canine adipose tissue-derived stromal cellsLim, J-H, Mariani CL, Piedrahita JA, Olby NJ | Cellular Reprogram 2010;12(4):417-25
  • (2010) Prevalence of Urinary Tract Infection in Dogs Following Surgery for Thoracolumbar Intervertebral Disc ExtrusionOlby NJ, Mackillop E, Cerda-Gonzalez S, Moore S, Munana KR, Grafinger M, Osborne JA, Vaden S. | J Vet Int Med 2010;24:1106-11
  • (2009) Pharmacokinetics of 4-aminopyridine derivatives in dogs.Olby NJ, Smith DT, Humphrey J, Spinapolice K, Parke N, Mehta PM, Dise D, Papich M. | J Vet Pharmacol Ther. 2009 Oct;32(5):485-91.PMID: 19754916.
  • (2009) Solitary intracerebral plasmacytoma in a dog: microscopic, immunohistochemical, and molecular features.Van Wettere AJ, Linder KE, Suter SE, Olby NJ. | Vet Pathol. 2009 Sep;46(5):949-51. doi: 10.1354/vp.08-VP-0012-V-BC. Epub 2009 May 9.
  • (2009) Characteristics of Cerebrospinal Fluid Flow in Cavalier King Charles Spaniels Analyzed Using Phase Velocity Contrast Cine Magnetic Resonance Imaging.Cerda-Gonazalez S, Olby NJ, Broadstone R, McCullough S, Osborne JA. | Vet Radiol Ultrasound 2009 Sep-Oct;50(5):467-76. Dr. Olby was primary advisor.
  • (2009) ‘Putting our heads together’: insights into genomic conservation between human and canine intracranial tumors.  Thomas R, Duke SE, Wang H, Breen T, Higgins RJ, Linder K, Ellis P, Langford CF, Dickinson PJ, Olby NJ and Breen M. | Journal of neuro-oncology 2009 Sep;94(3):333-49. doi: 10.1007/s11060-009-9877-5. Epub 2009 Mar 31.
  • (2009) Genome-wide association analysis identifies a SOD1 missense mutation in dogs with degenerative myelopathy: A spontaneous animal model for amyotrophic lateral sclerosisAwano T, Johnson GS, Wade CM, Katz ML, Johnson GC, Taylor JF, Perloski M, Biagi T, Long S, March PA, Olby NJ, Khan S, O’Brien DP, Lindblad-Toh K & Coates JR. | Proc Nat Acat Sci 2009;106:2794-9.
  • (2009) Morphology of the Caudal Fossa in Cavalier King Charles Spaniels.Cerda-Gonazalez SC, Olby NJ, McCullough S, Pease AP, Broadstone R, Osborne J. | Vet Radiol Ultrasound 2009 Jan-Feb;50(1):37-46. Dr Olby was primary adviser
  • (2009) Degenerative Myelopathy in 18 Pembroke Welsh Corgi Dogs.March P, Coates J, Abyad R, Williams D, O'Brien D, Olby N, Keating J, Oglesbee M. | Vet Pathol. 2009;46:241-50
  • (2009) Pharmacogenetic association study of 30 genes with phenobarbital drug response in epileptic dogs.Kennerly EM, Idaghdour Y, Olby NJ, Muñana KR, Gibson GC. | Pharmacogenetics and Genomics 2009; 19:911-922.
  • (2008) Management of acute spinal cord injuriesKube S, Olby NJ | Comp Cont Ed Vet Med 2008;30:496-504
  • (2007) Neurologic Dysfunction in Hypothyroid, Hyperlipidemic Labrador Retrievers.Vitale C, Olby NJ. | J Vet Int Med 2007;21:1316-22. Dr. Olby was primary advisor.
  • (2007) Clinical Characterization of a Familial Degenerative Myelopathy in 21 Pembroke Welsh Corgi DogsCoates JR, March PA, Oglesbee M, Ruaux CG, Olby NJ, Berghaus RD, O’Brien DP, Keating JH, Johnson GS, Williams DA. | J Vet Int Med 2007;21:1323-31.
  • (2007) Congenital portosystemic shunts in six mature dogs with neurologic signs.Windsor RC, Olby NJ. | J Am Anim Hosp Assoc 2007;43:322-31. Dr. Olby was primary advisor.
  • (2007) Intramedullary cavernous malformation of the spinal cord in two dogs.MacKillop E, Olby NJ, Linder KE, Brown TT. | Vet Path 2007; 44:528-32.Dr. Olby was primary advisor
  • (2006) Correlation between reverse transcriptase (TERT) expression and MIB-1 expression in canine brain tumors- an important animal model for developing telomerase based therapeutics.Long S, Nicholson I, Argyle DJ, Nixon C, Botteron C, Olby N, Smith K, Rutteman G, Nasir, L. | Neuropath Appl Neurobiol 2006;32:662-73.
  • (2005) Microarray analysis of differentially expressed genes of primary tumors in the canine central nervous system.Thomson S, Kennerly E, Olby N, Mickelson JR, Hoffman DE, Dickinson PJ, Gibson G, Breen B. | Vet Pathol 2005;42:550-8.
  • (2004) Comparison of regional gene expression differences in the brains of the domestic dog humans.Kennerly E, Thomson S, Olby N, Breen B, Gibson G. | Human Genomics 2004;1:435-43.
  • (2004) Cortical Degeneration in Adult American Staffordshire Terriers.Olby, N.J. Blot S, Thibaud J-L, Phillips J, O'Brien DP, Burr J, Berg J, Brown T, Breen M Cerebellar | J Vet Intern Med 2004;18:201–208.
  • (2004) Recovery of pelvic limb function in dogs following acute intervertebral disc herniationsOlby, N.J. Harris, T., Burr, J., Muñana, K.R., Sharp, N.J.H. & Keene, B. | J Neurotrauma 2004;21:49-59.
  • (2004) Behavioural analysis for clinical spinal cord injury trials in veterinary medicine.Webb AA, Jeffery ND, Olby, N.J., Muir GD. | Vet Rec  2004;155:225-230.
  • (2004) Stabilisation of scoliosis in two koi (Cyprinus carpio).Govett PD, Olby NJ, Marcellin-Little DJ, Rotstein DS, Reynolds TL, Lewbart GA. | Vet Rec 2004 Jul 24;155(4):115-9.
  • (2003) Use of a multiplex polymerase chain reaction assay in the antemortem diagnosis of toxoplasmosis and neosporosis in the central nervous system of cats and dogs.Schatzberg SJ, Haley NJ, Barr SC, deLahunta A, Olby N, Muñana K, Sharp NJ. | American Journal of Veterinary Research 2003 Dec;64(12):1507-13.
  • (2003) The relationship between basilar artery resistive index, degree of ventriculomegaly and clinical signs in hydrocephalic dogs.Saito, M., Olby, N.J., Spaulding, K, Muñana K.R., Sharp, N.J.H. | Vet Radiol Ultrasound 2003;44:687-94. Dr. Olby was primary advisor.
  • (2003) Long term functional outcome of dogs with severe thoracolumbar spinal cord injuries.Olby, N.J., Harris T., Muñana, K., Skeen, T., & Sharp, N.J.H. | J Am Vet Med Assoc 2003; 222:762-769.
  • (2003) Spinal arachnoid cysts in 17 dogsSkeen, T, Olby, N.J. Muñana, K & Sharp, N.J.H. | J Am Anim Hosp Assoc. 2003;39:271-82. Dr. Olby was primary advisor.
  • (2002) The Use of Vagal Nerve Stimulation as a Treatment for Refractory Epilepsy in Dogs.Muñana, K.R., Vitek, S.M., Tarver, W.B., Haglund, M.M., Saito, M., Skeen, T.M., Sharp, N.J.H., Olby, N.J. | .J Am Vet Med Assoc. 2002;221:977-83.
  • (2002) Post-operative recovery and long term follow-up in 21 dogs undergoing dorsal laminectomy for caudal cervical spondylomyelopathy.De Risio L, Muñana K, Murray M, Olby N, Sharp N, Cuddon P. | Veterinary Surgery 2002;31:418-427.
  • (2001) Diagnosis of arachnoid cysts in the quadrigeminal cistern using ultrasonography.Saito, M., Olby, N.J., & Spaulding, K. | Vet Rad US 2001;42:435-439. Dr. Olby was primary advisor.
  • (2001) Risk factors for development of status epilepticus in dogs with idiopathic epilepsy and effects of status epilepticus on outcome and survival time: 32 cases (1990-1996).Saito M, Muñana KR, Sharp NJH, Olby NJ. | Journal of the American Veterinary Medical Association 2001;219:618-623.
  • (2001) Development of a functional scoring system in dogs with acute spinal cord injuriesOlby NJ, DeRisio L, Mu¤ana K, Wosar M, Skeen T, Sharp NJH, Keene BW | Am J Vet Res 2001;62:1624-1628
  • (2001) Predictors of outcome after dorsal decompressive laminectomy for degenerative lumbosacral stenosis in dogs: 69 cases (1987-1997).De Risio L, Sharp NJ, Olby NJ, Munana KR, Thomas WB. | J Am Vet Med Assoc. 2001;219624-8.
  • (2001) Intervertebral disc disease in 10 cats.Muñana KR, Olby NJ, Sharp NJH, Skeen T. | Journal of the American Animal Hospital Association 2001;37:384-389.
  • (2001) Evaluation of the dystrophin-glycoprotein complex, alpha-actinin, dysferlin and calpain 3 in an autosomal recessive muscular dystrophy in Labrador retrievers.Olby, N.J.  Sharp, N.J.H., Anderson, L.V.B., Kunkel, L.M. & Bönnemann, | Neuromusc Disord. 2001;11, 41-49.
  • (2000) The computed tomographic appearance of acute thoracolumbar intervertebral disc herniationsOlby NJ, Muna¤a KR, Sharp NJH, Thrall DG | Vet Rad US 2000;41,396-402
  • (1999) Chronic and acute compressive spinal cord lesions in dogs due to intervertebral disc herniation are associated with elevation in lumbar CSF glutamate concentration.Olby, N.J., Sharp, N.J.H., Muñana, K. & Papich, M. | J. Neurotrauma 1999;16,1217-1226.
  • (1999) Current concepts in the management of acute spinal cord injury.Olby, N.J. | J Vet Int Med 1999;13, 399-407.
  • (1999) Molecular analysis of a spontaneous dystrophin ‘knockout’ dog.Schatzberg, S., Olby. N., Steingold, S., Dickens, H., Breen, M. & Sharp. N. | Neuromusc Dis. 1999; 9, 289-295.
  • (1999) A polymerase chain reaction (PCR) screening strategy for the canine dystrophin promoter.Schatzberg, S., Olby. N., Steingold, S., Keene, B. Atkins, C., Meurs, K., Solomon, G., Wilton, S. & Sharp. N. | Am J Vet Res. 1999; 60, 1040-1046.
  • (1996) Primary demyelination and regeneration of ascending axons in the dorsal funiculus of the rat spinal cord following photochemically-induced injury.Olby, N.J. & Blakemore, W.F. | J Neurocytol. 1996; 25, 465-480.
  • (1996) Reconstruction of the glial environment of an ischaemic  lesion in the rat spinal cord by transplantation  of astrocytes.Olby, N.J. & Blakemore, W.F. | J  Neurocytol. 1996;25, 481-498.
  • (1996) A new method of quantifying the extent of tissue loss following spinal cord injury in the rat.Olby, N.J. & Blakemore, W.F. | Exp Neurol 1996;138, 82-92.
  • (1995) The use of transplanted glial cells to reconstruct glial environments in the C.N.S.Blakemore, W.F., Olby, N.J. & Franklin, R.J.M. | Brain Pathol 1995;5, 443-450.
  • (1995) The effect of injection technique on the passive spread of cells immediately  following transplantation into rat spinal cord white matter tracts.Olby, N.J., O'Leary M.T., Targett,  M.P. & Blakemore, W.F.  | Rest Neurol Neurosci. 1995; 7, 171-174.
  • (1994) Correlation of plain radiographic and lumbar myelographic findings with surgical findings in thoracolumbar  disc disease.Olby, N.J., Dyce, J. & Houlton, J.E.F.  | J Sm Anim Pract 1994;35, 345-350.

Canine Paralysis Study Suggests Spinal Cord Injuries Require Customized Treatments

A clinical trial from North Carolina State University involving paraplegic dogs has demonstrated that a one-size fits all approach is not ideal for treating spinal cord injuries. Instead, the study highlights the fact that the population of canine paraplegics – even those with the same type of injury – are very diverse, and that courses

Natasha Olby Recipient of Faculty Achievement Award from American Association of Veterinary Clinicians

Natasha Olby, professor of neurology at North Carolina State University’s College of Veterinary, is the recipient of the 2014 Faculty Achievement Award from the American Association of Veterinary Clinicians (AAVC). The award is presented to an AAVC member who has achieved national recognition in academic or institutional practice, teaching, research, or in another endeavor that

CVM Stem Cell Study Benefits Dogs with Spinal Cord Injuries

Tobi is a six-year-old cocker spaniel whose hind legs were paralyzed after he suffered a herniated disc in his spine. Although Tobi will never fully regain the use of his legs, he has benefitted from a clinical trial involving stem cell transplantation in dogs that is currently underway at North Carolina State University. See video

CVM Researchers Receive AKC Canine Health Foundation Grants

Researchers at the NC State University College of Veterinary Medicine have been awarded four grants totaling $347,893 from the AKC Canine Health Foundation (CHF) as part of the organization’s 2012 funding year. The AKC CHF-funded NC State CVM research projects are: Grant 1557: High-Resolution Cytogenetic Analysis of Histiocytic Malignancies and Development of a Targeted Assay

Morris Animal Foundation Supports CVM Stem Cell Research

The following is reprinted, in part, from an article by Kelley Weir from the current issue of Animal News, a publication of the Morris Animal Foundation. Stem cell research has blown the door of science wide open for new therapies to address diseases that animals face. Currently, adult stem cells are being investigated as treatments

CCMTR Hosts Symposium on Stem Cells, Regenerative Medicine

The State of North Carolina is well poised to play a central role in the area of regenerative medicine. Key medical institutions including UNC, Duke, and Wake Forest, coupled with the NC State University’s unique expertise in engineering and veterinary medicine, and the existence of collaborative networks such as the NC State Center for Comparative

CVM Research Helps Find Gene Responsible for Neurodegenerative Disease

A researcher in North Carolina State University’s College of Veterinary Medicine has helped to locate and identify a gene responsible for a fatal neurodegenerative disease that affects American Staffordshire terriers. This same gene may be responsible for a similar rare, fatal disease in humans. Its discovery will lead to improved screening and diagnosis of the

Morris Animal Foundation Supports CVM Research

Selected researchers at the North Carolina State University’s College Veterinary Medicine (CVM) are recipients of Morris Animal Foundation grants that total more than $1.2 million for investigations aimed at improving the health of dogs, cats, horses, and wildlife. More specifically, Morris Animal Foundation (MAF) is providing $1,212,671 to help support 12 different studies being conducted

Canine Spinal Cord Injury Program Tests New Drug

The Canine Spinal Cord Injury Program at North Carolina State University’s Veterinary Teaching Hospital is evaluating the efficacy of a drug being developed to improve hind limb function in chronically paralyzed dogs. The drug, a novel potassium channel antagonist or blocker, showed promise in a preliminary trial in dogs with spinal cord injuries. The clinical

CCMTR-led Research Team Seeking Brain Tumor Gene

Pinpointing the genes involved in human brain cancer can be like looking for a needle in a haystack, and sometimes the needle you find may not be the right one. By comparing human and canine genomes, researchers at North Carolina State University have discovered that a gene commonly believed to be involved in meningiomas—tumors that

CVM Researchers Interviewed for AKC Genome Barks (podcasts)

Lee Arnold of the American Kennel Club and Canine Health Foundation Boards of Directors hosts Genome Barks, an AKC-sponsored series of podcasts. Dr. Steve Suter on canine lymphoma cell lines. These cell lines will provide a tool to study the disease on a cellular level and determine the molecular behavior of lymphoma. Dr. Adam Birkenheuer

CVM Leads National Trial Involving Acute Disc Herniations in Canines

The College of Veterinary Medicine (CVM) is the lead investigator in a national trial evaluating the effectiveness of medical therapies combined with surgical treatment of severe acute disc herniations in dogs. A common problem in chondrodystrophoid breeds such as Dachshunds, Bassett Hounds, Pekinese, Beagles, and Lhasa Apsos, acute intervertebral disc herniations (IVDD) occur when the