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Lauren Schnabel, DVM, PhD, Dip. ACVS, Dip. ACVSMR

Assistant Professor, Equine Orthopedic Surgery

Contact:

lauren_schnabel@ncsu.edu
Office: 919.515.7410

Certifications
Diplomate, American College of Veterinary Surgeons (Large Animal)
Diplomate, American College of Veterinary Sports Medicine and Rehabilitation (Equine)
Regenerative Medicine
Regenerative therapies for the treatment of equine musculoskeletal disorders. In particular, my laboratory is focused on understanding the immunologic and immunomodulatory properties of both mesenchymal and induced pluripotent stem cells. Such knowledge is critical for potential allogeneic “off the shelf” stem cell therapy which would allow us to treat our patients at the time of diagnosis rather than having to wait several weeks to months to culture stem cells from that patient.

CLINICAL STUDIES
  • Induced pluripotent stem cells (iPSCs) have similar immunogenic and more potent immunomodulatory properties compared to bone marrow-derived stromal cells in vitro.Schnabel LV, Abratte CM, Schimenti JC, Felippe MJB, Cassano JM, Southard TL, Cross JA, Fortier LA. | Regen Med 2014; 9(5):621-635.
  • Equine bone marrow-derived mesenchymal stromal cells are heterogeneous in MHC class II expression and capable of inciting an immune response in vitro.Schnabel LV, Pezzanite LM, Antczak DF, Felippe MJB, Fortier LA. | Stem Cell Res Ther 2014; Jan 24;5(1):13.
  • Plasma and synovial fluid concentration of doxycycline following low-dose, low-frequency administration and resultant MMP-13 inhibition from interleukin-stimulated equine synoviocytes.Maher MC, Schnabel LV, Cross JA, Papich MG, Divers TJ, Fortier LA. | Equine Vet J 2014; 46(2):198-202.
  • Increasing platelet concentration in leukocyte-reduced platelet rich plasma decreases collagen gene synthesis in tendons.Boswell SG, Schnabel LV, Sundman EA, Minas T, Fortier LA. | Am J Sports Med 2014; 42(1): 42-49.
  • Therapeutic use of stem cells in horses: which type, how, and when?Schnabel LV, Fortier LA, McIlwraith CW, Nobert KM. | Vet J 2013; 197(3): 570-577. Invited Review.
  • Use of a formal assessment instrument for the evaluation of veterinary student surgical skills.Schnabel LV, Maza PS, Williams KM, Irby NL, McDaniel CM, Collins BG. | Vet Surg 2013; 2(4): 488-496.
  • Comparison of three methods to quantify repair cartilage collagen orientation.Ross KA, Williams RM, Schnabel LV, Mohammed HO, Potter HG, Bradica G, Castiglione E, Pownder SL, Satchell PW, Saska R, Fortier LA. | Cartilage 2013; 4(2): 111-120.
  • Genetic background affects induced pluripotent stem cell (iPSC) generation.Schnabel LV, Abratte CM, Schimenti JC, Southard TL, Fortier LA. | Stem Cell Res Ther 2012; 3(4):30.
  • Pharmacokinetics and distribution of minocycline in adult horses after oral administration of multiple doses and comparison to minimum inhibitory concentrations.Schnabel LV, Papich MG, Divers TJ, Altier C, Aprea MS, McCarrel TM, Fortier LA. | Equine Vet J 2012;44(4):453-8.
  • Cell and gene based approaches in tendon regenerative medicine.Nixon AJ, Watts AE, Schnabel LV. | J Shoulder Elbow Surg 2012;21(2):278-294. Invited Review.
  • Size and geometry of apical sesamoid fracture fragments as a determinant of prognosis in Thoroughbred racehorses.Kamm JL, Bramlage LR, Schnabel LV, Ruggles AJ, Embertson RM, Hopper SA. | Equine Vet J 2011; 43(4):412-417.
  • Orally administered doxycycline accumulates in synovial fluid compared to plasma.Schnabel LV, Papich MG, Watts AE, Fortier LA. | Equine Vet J 2010; 42(3):208-212.
  • Concentrated bone marrow aspirate improves full-thickness cartilage repair compared to microfracture in an equine model of extensive cartilage loss.Fortier LA, Potter HG, Rickey LJ, Schnabel LV, Ellsworth JR, Foo LF, Chong LR, Stokol T, Nixon AJ, Cheetham JC. | J Bone Joint Surg Am 2010; 92(10):1927-1937.
  • Imaging diagnosis-equine nasal septal thickening due to chronic chondritis.Sharma A, Thompson MS, Schnabel LV, Mete A, Hackett R. | Vet Radiol Ultrasound 2010; 51(1): 65-68.
  • Mesenchymal stem cells and insulin-like growth factor-I gene enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons.Schnabel LV, Lynch ME, van der Meulen MCH, Yeager AE, Kornatowski MA, Nixon AJ. | J Orthop Res 2009; 27(10):1392-1398.
  • Trochlear block recession in an alpaca with traumatic lateral patellar luxation.Furman S, Fortier LA, Schnabel LV, Krotscheck U. | Vet Surg 2009; 38(3):421-425.
  • Effects of platelet rich plasma and acellular bone marrow on gene expression patterns and DNA content of equine suspensory ligament explant cultures.Schnabel LV, Mohammed HO, Jacobson MS, Fortier LA. | Equine Vet J 2008; 40(3):260-265.
  • Gene Therapy in Musculoskeletal Repair.Nixon AJ, Goodrich LR, Scimeca MS, Witte TH, Schnabel LV, Watts AE, Robbins PD. | Ann NY Acad Sci. 2007; 1117:310-327. Invited Review.
  • Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons.Schnabel LV, Mohammed HO, Miller BJ, McDermott WG, Jacobson MS, Santangelo, KS, Fortier LA. | J Orthop Res 2007; 25(2):230-240.
  • Racing performance after arthroscopic removal of apical sesamoid fracture fragments in immature Thoroughbred horses, < 2 years old: 151 cases (1989-2002).Schnabel LV, Bramlage LR, Mohammed HO, Embertson RM, Ruggles AJ, Hopper SA. | Equine Vet J 2007; 39(1):64-68.
  • Assessment of cartilage degradation effects of matrix metalloproteinase-13 in equine cartilage co-cultured with synoviocytes.Fortier LA, Schnabel LV, Mohammed HO, Mayr KG. | Am J Vet Res 2007; 68(4):379-384.
  • Racing performance after arthroscopic removal of apical sesamoid fracture fragments in Thoroughbred horses ages 2 years and older: 84 cases (1989-2002).Schnabel LV, Bramlage LR, Mohammed HO, Embertson RM, Ruggles AJ, Hopper SA. | Equine Vet J 2006; 38(5):446-451.
  • Primary alimentary lymphoma with metastasis to the liver causing encephalopathy in a horse.Schnabel LV, Njaa BL, Gold JR, Meseck EK. | J Vet Intern Med 2006; 20:204-206
  • Equine allogeneic mesenchymal stromal cells elicit antibody responses in vivo.Pezzanite LM, Fortier LA, Antczak DF, Cassano JM, Brosnahan MM, Miller D, Schnabel LV. | Stem Cell Res Ther 2015; in press.
  • Mesenchymal stem cells - have we delivered on the promise?Cassano JM, Schnabel LV, Betancourt A, Fortier LA. | Curr Pathobiol Rep 2015; in press. Invited Review.
  • Navigational ultrasound imaging: A valuable new tool for improving the accuracy of interventional therapy in the treatment of equine musculoskeletal injuries.Lustgarten M, Redding WR, Schnabel LV, Prange T, Seiler GS. | Equine Vet J 2014; in press.
  • Laparoscopic-guided compared to skilled instructor support for student rectal examination training using live horses in the veterinary curriculum.Radcliffe RM, Manchester A, Mohammed HO, Ortved KF, Reesink HL, Schnabel LV, Lang HM, Scrivani PV, Fubini SL. | Vet Surg 2014; in press.