Lauren Schnabel

Bio

Lauren is a Professor of Equine Orthopedic Surgery in the Department of Clinical Sciences at NC State College of Veterinary Medicine. She completed her DVM, Large Animal Surgery Residency, and PhD at Cornell University under the mentorship of Dr. Lisa Fortier and Dr. Douglas Antczak. She is board certified in both the American College of Veterinary Surgery and the American College of Veterinary Sports Medicine and Rehabilitation. Lauren’s research focuses on stem cell immunology, use of biologic therapies to treat musculoskeletal injuries and diseases, and advancing equine rehabilitation protocols.

Lab: The Schnabel Lab

Lab Phone: (919) 515.7410

Area(s) of Expertise

GLOBAL HEALTH, REGENERATIVE MEDICINE

Regenerative therapies for the treatment of equine musculoskeletal disorders. In particular, my laboratory is focused on understanding the immunologic and immunomodulatory properties of both mesenchymal and induced pluripotent stem cells. Such knowledge is critical for potential allogeneic “off the shelf” stem cell therapy which would allow us to treat our patients at the time of diagnosis rather than having to wait several weeks to months to culture stem cells from that patient.

Publications

• A NOVEL MATRIKINE STIMULATED EQUINE SYNOVIAL FIBROBLAST AND CHONDROCYTE COCULTURE MODEL OF OSTEOARTHRITIS: A PROPOSED ALTERNATIVE TO TRADITIONAL LPS AND IL-1B MODELS , OSTEOARTHRITIS AND CARTILAGE (2024)
• Controlled Stiffness of Direct-Write, Near-Field Electrospun Gelatin Fibers Generates Differences in Tenocyte Morphology and Gene Expression , Journal of Biomechanical Engineering (2024)
• Editorial: Links between regenerative medicine and immunotherapy: how cellular therapies modulate immune responses for improved outcomes , FRONTIERS IN VETERINARY SCIENCE (2024)
• Fighting fibrin with fibrin: Vancomycin delivery into coagulase-mediated Staphylococcus aureus biofilms via fibrin-based nanoparticle binding , JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2024)
• IL-1β + TGF-β2 dual-licensed mesenchymal stem cells have reduced major histocompatibility class I expression and positively modulate tenocyte migration, metabolism, and gene expression , JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION (2024)
• Pyrrolidine-2,3-diones: heterocyclic scaffolds that inhibit and eradicate S. aureus biofilms , CHEMICAL COMMUNICATIONS (2024)
• Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs , FRONTIERS IN PHARMACOLOGY (2024)
• Systemic absorption of triamcinolone acetonide is increased from intrasynovial versus extrasynovial sites and induces hyperglycemia, hyperinsulinemia, and suppression of the hypothalamic-pituitary-adrenal axis , FRONTIERS IN VETERINARY SCIENCE (2024)
• Ultrasoft platelet-like particles stop bleeding in rodent and porcine models of trauma , SCIENCE TRANSLATIONAL MEDICINE (2024)
• Antimicrobial Properties of Equine Stromal Cells and Platelets and Future Directions , VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE (2023)