Samuel Jones

Bio

Dr. Jones received his DVM from the University of Tennessee in 1988, and his PhD in Immunology from Washington University in 1998. He is the Director of both the Comparative Biomedical Sciences Program and the Combined DVM/PhD Program at the NC State College of Veterinary Medicine.

CERTIFICATIONS

Diplomate, American College of Veterinary Internal Medicine

Area(s) of Expertise

IMMUNOLOGY
My lab investigates how inflammation is triggered and regulated and how inflammation contributes to the pathophysiology of diseases such as colitis, equine colic, sepsis, and endotoxemia. A primary objective of our work is to understand the cellular and molecular details of cell migration with a focus on the key innate immune cells called neutrophils. We are particularly interested in how the signaling molecules protein kinase A, phosphatidylinositol 3-kinase, and p38 and the actin binding proteins MARCKS, VASP, and L-Plastin regulate the actin cytoskeleton, integrin function, and signaling during migration of neutrophils and other cells. We use human and equine primary cells, cell lines, and in vivo models including mice and zebrafish for these studies. Our lab is also studying how inflammation is triggered and pro-inflammatory genes are upregulated in equine leukocytes. We are studying the responses of equine leukocytes to lipopolysaccharide (endotoxin) and current studies include the mechanism upregulating a number of genes in the prostaglandin synthesis cascade, particularly cyclooxygenase-2 and prostaglandin synthase-1. We also collaborate extensively with Dr. Anthony Blikslager to study the effects of neutrophils and inflammatory mediators on intestinal mucosal repair following ischemic injury such as occurs in some forms of equine colic. Our clinical studies include equine Bartonellosis, equine colic, right dorsal ulcerative colitis, and hepatic injury in horses with intestinal diseases.

Publications

• A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in & beta;(2)-integrin activation and signaling , CELL ADHESION & MIGRATION (2023)
• Withaferin A Inhibits Neutrophil Adhesion, Migration, and Respiratory Burst and Promotes Timely Neutrophil Apoptosis , FRONTIERS IN VETERINARY SCIENCE (2022)
• Pharmacokinetics and ex vivo anti‐inflammatory effects of oral misoprostol in horses , Equine Veterinary Journal (2018)
• Endothelial alterations in a canine model of immune thrombocytopenia , Platelets (2017)
• Inhibition of microsomal prostaglandin E-synthase-1 (mPGES-1) selectively suppresses PGE 2 in an in vitro equine inflammation model , Veterinary Immunology and Immunopathology (2017)
• Misoprostol Inhibits Equine Neutrophil Adhesion, Migration, and Respiratory Burst in an In Vitro Model of Inflammation , Frontiers in Veterinary Science (2017)
• Misoprostol Inhibits Lipopolysaccharide-Induced Pro-inflammatory Cytokine Production by Equine Leukocytes , Frontiers in Veterinary Science (2017)
• Diagnostic procedures in the examination of the equine alimentary system , Large Animal Internal Medicine (2015)
• Disorders of the esophagus , Large Animal Internal Medicine (2015)
• Non-steroidal anti-inflammatory drug toxicity , Large Animal Internal Medicine (2015)

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