Cell Biology

Overview

The Cell Biology Concentration Area encompasses research at the molecular and cellular levels in the following disciplines: gastroenterology, oncology, pulmonary biology, ophthalmology, reproductive endocrinology, pharmacology, neurophysiology and neuroanatomy, and cellular differentiation and morphogenesis. Research approaches employ a wide variety of molecular, biochemical, pharmacological, and microscopic techniques, utilizing cell culture and whole organisms. Students selecting Cell Biology will focus their research efforts on one or more of these areas.

A highly individualized curriculum of study is designed to meet the needs and interests of the student while satisfying selected requirements by the faculty. These include graduate level cell biology, biochemistry, and cell biology seminars. Additional courses may be chosen by the student and his/her advisor from a large number of college and university offerings.

COURSES REQUIRED FOR THE CELL BIOLOGY CONCENTRATION

GN701 Molecular Genetics; Fall (3 credits)

CBS 770 Cell Biology; Spring (4 credits)

CBS 810 Seminar in Cell Biology (1 credit; minimum 3 credits total for doctoral students; minimum 2 credits total for master’s students)

ELECTIVE COURSES

Elective courses are selected by the student and mentor, and must be approved by the student’s graduate advisory committee. Possible elective course include, but are not limited to, the following:

BCH 701 Macromolecular Structure; Fall (3 credits)

BCH 703 Macromolecular Synthesis and Regulation; Fall (3 credits)

BCH 705 Molecular Biology of the Cell; Spring (3 credits)

GN 701 Molecular Genetics; Fall (3 credits)

GN 702 Cellular and Developmental Genetics; Spring (3 credits)

GN 750 Developmental Genetics; Spring alternate years(3 credits)

GN/MB 758 Microbial Genetics & Genomics; Spring (3 credits)

GN 761 Advanced Molecular Biology of the Cell; Spring alternate years (3 credits)

GN/BCH 768 Nucleic Acids: Structure and Function; Spring alternate years (3 credits)

CBS/IMM/MB 783 Advanced Immunology; Fall alternate odd years (3 credits)

CBS/IMM 816 Advanced Topics in Immunology; Fall (1 credits)

MB 718 Introductory Virology; Fall alternate odd years (3 credits)

IMM/TOX 705 Immunotoxicology; Spring (2 credits)

IMM 751 Immunology; Spring (3 credits)

PHY 503, 504 General Physiology I and II (3 credits)

PHY 702 Reproductive Physiology of Mammals; Fall & Spring (3 credits)

PHY 780 Mammalian Endocrinology (3 credits)

ST 701 Statistical Theory I; Fall (3 credits)

TOX 501 Principles of Toxicology; Spring (4 credits)

Participating Faculty

Name	Email	Primary Concentration	Other Concentrations	Research Emphasis
Amanda Ziegler	amanda_ziegler@ncsu.edu	Cell Biology		Development of epithelial barrier repair signaling in the neonatal gut
Anthony Blikslager	anthony_blikslager@ncsu.edu	Cell Biology		Mechanisms of intestinal mucosal injury and repair
Ashley Brown	aecarso2@ncsu.edu	Cell Biology	Immunology	Dr. Brown leads the Advanced Wound Healing lab.
Breanna Sheahan	bjsheaha@ncsu.edu	Cell Biology		The Sheahan Lab is focused on equine gastrointestinal diseases and finding new therapies to treat or prevent these diseases.
Brian Gilger	bgilger@ncsu.edu	Pharmacology	Cell Biology	Ocular inflammation, drug delivery, gene therapy, fungal keratitis, and imaging of the eye
Caroline Laplante	claplan@ncsu.edu	Cell Biology		Understanding how a mother cell divides into two daughter cells.
Carolyn Mattingly	bcallah@ncsu.educjmattin@ncsu.edu	Cell Biology	Pharmacology, Population Medicine and Global Health	My overarching professional goal is to improve understanding about environmental influences on human health and disease. Currently, I am doing this by: Overseeing the ongoing development and expansion of the Comparative Toxicogenomics Database (CTD), Providing administrative oversight of NC State’s Superfund Center for Environmental and Health Effects of PFAS.
Caroline McKinney-Aguirre	camckinn@ncsu.edu	Cell Biology		The role of intestinal stem cells and their interaction with elements of the intestinal microenvironment, like bacteria.
Christophe Guilluy	cdguillu@ncsu.edu	Cell Biology		Investigating how mechanical constraints control cellular behavior in physiology and disease.
Duncan Lascelles	dxlascel@ncsu.edu	Cell Biology	Neurosciences	Measurement and neurobiology of pain in induced and naturally occurring animal models
Erik (Yen-Hao) Lai	ylai7@ncsu.edu	Cell Biology	Radiation Oncology
Glenn Cruse	gpcruse@ncsu.edu	Immunology	Cell Biology, Pharmacology	Translational research in mast cell-driven diseases such as allergy, asthma and mastocytosis.
Ian Williamson	orgnaoidian@ncsu.edu	Cell Biology	Neurosciences, Pharmacology	Enterocyte metabolism and nutrient uptake
James Bonner	jcbonner@ncsu.edu	Cell Biology	Toxicology	Our goal is to explore and investigate mechanisms of environmental lung diseases (asthma, fibrosis, cancer) caused by emerging toxicants that pose a threat to human health and the environment.
Javier Lopez Soto	ejlopezs@ncsu.edu	Neurosciences	Cell Biology	Neurosciences and Cell Biology
Jeffrey Eells	jbeells@ncsu.edu	Cell Biology		The overarching theme of my research is understanding how the environment can alter brain function.
Jeff Yoder	jayoder@ncsu.edu	Immunology	Infectious Disease, Cell Biology	We study the evolution of immune receptors and PFAS immunotoxicology.
Jennifer Halleran	jjlhaller@ncsu.edu	Pharmacology	Cell Biology, Infectious Diseases	Antimicrobial Resistance
Jody Gookin	jgookin@ncsu.edu	Cell Biology	Infectious Diseases	Host-pathogen Interactions in the Gut
Jonathan Hall	jrhall@ncsu.edu	Cell Biology		Research in the Hall Lab is focused on the identification and characterization of genes and signaling pathways that determine susceptibility to skin cancer.
Jorge Piedrahita	japiedra@ncsu.edu	Cell Biology		Use of stem cells in regenerative medicine
Joshua Stern	jastern@ncsu.edu	Cell Biology	Pathology	The Stern laboratory studies spontaneous animal models of familial cardiac disease. Our research efforts focus on identification of causative mutations in spontaneous animal models, evaluation of cardiovascular pharmacogenetic effects and the study of novel cardiovascular therapeutics.
Kelly Ann Meiklejohn	kameikle@ncsu.edu	Cell Biology		New techniques for analyzing forensic evidence using next generation sequencing.
Michala de Linde Henriksen	mhenrik@ncsu.edu	Cell Biology	Pharmacology	Dr. Henriksen's research interest is immunotherapy of ocular diseases, such as anterior uveitis, as well as ocular microbiology with a focus on infected corneal ulcerations.
Kenneth Adler	kbadler@ncsu.edu	Cell Biology		molecular mechanisms of inflammation and carcinogenesis
Lauren Schnabel	lvschnab@ncsu.edu	Cell Biology	Immunology, Infectious Disease	The Schnabel Laboratory focuses on the use of regenerative and biologic therapies for the treatment of musculoskeletal injuries.
Laurianne Van Landeghem	lcvanlan@ncsu.edu	Cell Biology	Neurosciences	My lab explores how cues emanating from the microenvironment regulate intestinal epithelial (stem) cells in health and diseases with a special emphasis on cells belonging to the enteric nervous system.
Liara Gonzalez	lmgonza4@ncsu.edu	Cell Biology		Utilizing large animal models to study intestinal stem cell dynamics during clinically relevant disease states.
Matthew Breen	Matthew_Breen@ncsu.edu	Cell Biology	Pathology	Genetics, genomics, comparative aspects of animal and human health.
Michael Nolan	mwnolan@ncsu.edu	Cell Biology	Neurosciences	We study the intersection of cancer and pain.
Michele Battle	mabattle@ncsu.edu	Cell Biology		Cellular and Molecular Gastroenterology and Hepatology
Mike Sano	msano2@ncsu.edu	Cell Biology		Dr. Sano‘s lab studies the complex interaction between cells/tissues and electric fields.
Nanette Nascone-Yoder	nmnascon@ncsu.edu	Cell Biology		organ development
Natasha Olby	njolby@ncsu.edu	Neurosciences	Cell Biology, Pathology	My laboratory focuses on neurological disease in companion dogs with areas of research encompassing aging of the nervous system and neurodegenerative disease, neuropathic pain, and spinal cord injury.
Neil McCarthy	nmccart@ncsu.edu	Cell Biology	Pathology	Dr. McCarthy's lab investigates intestinal mesenchymal function in development, health, and disease.
Nicolas Buchler	nebuchle@ncsu.edu	Cell Biology		Fungi, cell cycle, evolution, quantitative biology.
Paul Mozdziak	pemozdzi@ncsu.edu	Cell Biology		Muscle Biology and Cellular Agriculture.
Ronald Li	rhli2@ncsu.edu	Cell Biology	Immunology	Dr. Li's research focus is directed towards understanding the cellular basis and pathobiological roles of immunothrombosis, by which neutrophils and platelets interact in cardiovascular diseases and systemic inflammation. His research also includes investigating precision medicine, congenital platelet disorders and novel antiplatelet therapy in cardiovascular diseases.
Rosemary Bayless	rlbayles@ncsu.edu	Cell Biology	Immunology, Pharmacology	The Bayless Lab team studies neutrophil biology with the goal of identifying innovative therapeutic targets and developing novel treatments for neutrophil-mediated conditions across veterinary and human patients.
Samuel Jones	sljones@ncsu.edu	Cell Biology	Immunology	Regulation of Neutrophil Motility
Sarah Shelton	seshelto@ncsu.edu	Cell Biology		Dr. Shelton’s lab designs microfluidic, organ-on-chip models of disease to uncover how the tissue microenvironment and cellular interactions shape pathology and treatment response.
Seth Kullman	swkullma@ncsu.edu	Cell Biology		Developmental Endocrinology
Shobhan Gaddameedhi	sgaddam4@ncsu.edu	Cell Biology		Overall, research from the Gaddameedhi lab provides a mechanistic understanding of the biological clock’s role in ‘gene-environment’ interactions and its impact on environmental disease prevention, toxicant exposures, and therapeutic efficacy.
Yea Ji Jeong	yjeong5@ncsu.edu	Cell Biology	Pathology, Population Medicine	Dr. Jeong’s research focuses on creating a precision oncology platform for animal patients.